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T0901317

T0901317 Structure
T0901317
  • CAS No.293754-55-9
  • Chemical Name:T0901317
  • CBNumber:CB0368768
  • Molecular Formula:C17H12F9NO3S
  • Formula Weight:481.33
  • MOL File:293754-55-9.mol
T0901317 Property
  • Melting point 116-118°C
  • Boiling point 470.5±55.0 °C(Predicted)
  • Density 1.550±0.06 g/cm3(Predicted)
  • storage temp. -20°C
  • solubility DMSO (Slightly), Methanol (Slightly)
  • pka 9.00±0.15(Predicted)
  • form Light beige solid
  • color Off-White
  • InChIKey SGIWFELWJPNFDH-UHFFFAOYSA-N
  • FDA UNII A07663A39I
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • WGK Germany  :3
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
T0901317 Price More Price(3)
  • Brand: Sigma-Aldrich(India)
  • Product number: T2320
  • Product name : T0901317
  • Purity: ≥98%
  • Packaging: 5MG
  • Price: ₹6917.18
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: T2320
  • Product name : T0901317
  • Purity: ≥98%
  • Packaging: 10MG
  • Price: ₹11063.15
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 575310
  • Product name : T0901317 - CAS 293754-55-9 - Calbiochem
  • Purity: A cell-permeable, nonsterol, benzenesulfonamide compound that acts as a highly selective and potent liver X receptor agonist (EC?? of 20 nM for LXRα).
  • Packaging: 10MG
  • Price: ₹18990
  • Updated: 2022/06/14
  • Buy: Buy

T0901317 Chemical Properties,Usage,Production

  • Uses The Liver X Receptors (LXRα and LXRβ) are nuclear hormone receptors whose native ligands are oxysterols, such as 22(R)-hydroxycholesterol. The LXRs regulate the oxysterol-induced expression of cholesterol 7α-hydroxylase, the rate limiting enzyme of classic bile acid synthesis. T0901317 is a potent and selective agonist for both LXRα and LXRβ, with an EC50 of about 50 nM. T0901317 acting through LXR and in concert with its RXR heterodimerization partner induces the expression of the ABCA1 reverse cholesterol transporter. This acts to increase the efflux of cholesterol from enterocytes and thus inhibit the overall absorption of cholesterol.
  • Uses T0901317 is a potent and selective agonist for both liver x receptor (LXR) and farnesoid X receptor (FXR).
  • General Description A cell-permeable, nonsterol, benzenesulfonamide compound that acts as a highly selective and potent liver X receptor agonist (EC50 = 20 nM for LXRα). Reported to induce the expression of genes associated with fatty acid biosynthesis. Raises the levels of serum HDL cholesterol and triglycerides in mice and inhibits the development of atherosclerosis in LDL receptor-deficient mice. Also shown to lower plasma glucose levels in diabetic rodents.
  • Biological Activity Potent, high affinity liver X receptor (LXR) agonist (EC 50 ~ 50 nM, Kd values are 7 and 22 nM for LXR- α and LRXR- β respectively). Upregulates expression of the ABCA1 gene associated with cholesterol efflux regulation and HDL metabolism. Decreases amyloid- β production in primary neurons in vitro . Displays an EC 50 of ~ 5 μ M for activation of bile acid farnesoid X receptors (FXRs); 10-fold more potent than natural FXR ligand chenodeoxycholic acid.
  • Biochem/physiol Actions Cell permeable: yes
  • storage Store at +4°C
  • References [1]. schultz j r, tu h, luk a, et al. role of lxrs in control of lipogenesis[j]. genes & development, 2000, 14(22): 2831-2838.
    [2]. kumar n, solt l a, conkright j j, et al. the benzenesulfoamide t0901317 [n-(2, 2, 2-trifluoroethyl)-n-[4-[2, 2, 2-trifluoro-1-hydroxy-1-(trifluoromethyl) ethyl] phenyl]-benzenesulfonamide] is a novel retinoic acid receptor-related orphan receptor-α/γ inverse agonist[j]. molecular pharmacology, 2010, 77(2): 228-236.
    [3]. houck k a, borchert k m, hepler c d, et al. t0901317 is a dual lxr/fxr agonist[j]. molecular genetics and metabolism, 2004, 83(1): 184-187.
    [4]. liu y, yan c, wang y, et al. liver x receptor agonist t0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice[j]. endocrinology, 2006, 147(11): 5061-5068.
T0901317 Preparation Products And Raw materials
Raw materials
Preparation Products
T0901317 Suppliers
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T0901317 Spectrum
293754-55-9, T0901317Related Search:
  • Inhibitors
  • Gene Regulation and Expression
  • Cell Signaling and Neuroscience
  • PPAR and RXR Regulators
  • 医用原料
  • 抑制剂
  • 生物试剂
  • 合成有机化合物配体
  • 原料药
  • 标准品
  • 生化试剂
  • 细胞生物学试剂
  • 小分子抑制剂，天然产物
  • Gene Regulation and Expression
  • PPAR and RXR Regulators
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience
  • C17H12F9NO3S
  • C17H12NSO3F9
  • 化合物T0901317,10 MM DMSO 溶液
  • 化合物 T0901317
  • T0901317,LXR激动剂
  • T0901317 CALBIOCHEM
  • T0901317,非LXR激动剂
  • N-(4-(1,1,1,3,3,3-六氟-2-羟基丙-2-基)苯基)-N-(2,2,2-三氟乙基)苯磺酰胺
  • S 055746,BCL201
  • LXR和FXR激动剂(T0901317)
  • N-(2,2,2-三氟乙基)-N-[4-[2,2,2-三氟-1-羟基-1-(三氟甲基)乙基]苯基]苯磺酰胺
  • 293754-55-9
  • T0901317, 10 mM in DMSO
  • T0901317, LXR agonist
  • TO-91317
  • TO-091317
  • TO091317
  • TO 091317
  • N-(2,2,2-Trifluoroethyl)-N-4-2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethylphenylbenzenesulfonamide
  • T0901317 293754-55-9
  • N-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)-N-(2,2,2-trifluoroethyl)benzenesulfonamide
  • N-(2,2,2-trifluoroethyl)
  • T0901317 (T-1317)
  • CS-721
  • T0901317 - CAS 293754-55-9 - Calbiochem
  • N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]
  • T0901317;T 0901317; T-0901317
  • T 1317
  • BenzenesulfonaMide, N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoroMethyl)ethyl]phenyl]-
  • TO-901317
  • T0901317
  • N-(2,2,2-TRIFLUOROETHYL)-N-[4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL]BENZENESULFONAMIDE

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