ChemicalBook > CAS DataBase List > 9,11-DIDEOXY-9ALPHA,11ALPHA-EPOXY-METHANOPROSTAGLANDIN F2ALPHA

9,11-DIDEOXY-9ALPHA,11ALPHA-EPOXY-METHANOPROSTAGLANDIN F2ALPHA

9,11-DIDEOXY-9ALPHA,11ALPHA-EPOXY-METHANOPROSTAGLANDIN F2ALPHA Structure
9,11-DIDEOXY-9ALPHA,11ALPHA-EPOXY-METHANOPROSTAGLANDIN F2ALPHA
  • CAS No.56985-32-1
  • Chemical Name:9,11-DIDEOXY-9ALPHA,11ALPHA-EPOXY-METHANOPROSTAGLANDIN F2ALPHA
  • CBNumber:CB5165643
  • Molecular Formula:C21H34O4
  • Formula Weight:350.49
  • MOL File:56985-32-1.mol
9,11-DIDEOXY-9ALPHA,11ALPHA-EPOXY-METHANOPROSTAGLANDIN F2ALPHA Property
  • Flash point -13℃
  • storage temp. −20°C
  • solubility ≤100mg/ml in ethanol;100mg/ml in DMSO;100mg/ml in dimethyl formamide
  • form solution in acetate.
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H225-H319-H336
  • Precautionary statements P210-P305+P351+P338
9,11-DIDEOXY-9ALPHA,11ALPHA-EPOXY-METHANOPROSTAGLANDIN F2ALPHA Price More Price(3)
  • Brand: Sigma-Aldrich(India)
  • Product number: D0400
  • Product name : 9,11-Dideoxy-9α,11α-epoxymethanoprostaglandin F2α
  • Purity: 
  • Packaging: 1MG
  • Price: ₹25373.8
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: D0400
  • Product name : 9,11-Dideoxy-9α,11α-epoxymethanoprostaglandin F2α
  • Purity: 
  • Packaging: 5MG
  • Price: ₹101257.05
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: D0400
  • Product name : 9,11-Dideoxy-9α,11α-epoxymethanoprostaglandin F2α
  • Purity: 
  • Packaging: 10MG
  • Price: ₹181556.9
  • Updated: 2022/06/14
  • Buy: Buy

9,11-DIDEOXY-9ALPHA,11ALPHA-EPOXY-METHANOPROSTAGLANDIN F2ALPHA Chemical Properties,Usage,Production

  • Uses U-44069 is a stable analog of the endoperoxide PGH2, and a TP receptor agonist. U-44069 stimulates shape change in human platelets without a measurable increase in [Ca2+] with an EC50 of 1.8 nM. U-44069 has an EC50 of 3 μM and 54 nM for platelet aggregation and phosphatidate formation in human platelets, respectively.
  • Definition ChEBI: U-44069 is a prostanoid.
  • Biological Activity ec50: 3 μm and 54 nm for platelet aggregation and phosphatidate formation in human platelets, respectivelyu-44069 is a tp receptor agonist.increased production of vasoconstrictive prostanoids, such as thromboxane a2, contributes to endothelial dysfunction and increased hepatic vascular tone in cirrhosis. thromboxane a2 induces vasoconstriction via activation of the thromboxane-a2 /prostaglandin-endoperoxide (tp) receptor.
  • in vitro in a previous study, dose-response relationships for raised cytoplasmic free calcium concentration and shape change were simultaneously measured. with the calcium ionophore ionomycin the threshold of free calcium concentration for shape change was 300 nm with a maximal response at 800 nm. with 1 mm external free calcium concentration the u44069 concentrations required to stimulate half-maximal shape change and an increase in free calcium concentration were 2 and 41 nm, respectively. low levels of u44069 could evoke substantial shape change without any rise in free calcium concentration. in the absence of external calcium, u44069 was able to stimulate half-maximal shape change at 2 nm, and half-maximal elevation of free calcium concentration at 69 nm [1].
  • in vivo animal study showed that naive mice treated with either u-44069 at 25 or 100 μg/kg (iv), endothelin-1 (100 pmol, intranasally) or the et b receptor agonist irl-1620 (100 pmol, intranasally) had a marked increase in airway reactivity to carbachol [2].
  • References [1] simpson, a. w.m.,hallam, t.j., and rink, t.j. low concentrations of the stable prostaglandin endoperoxide u44069 stimulate shape change in quin2-loaded platelets without a measurable increase in [ca2+]i. febs letters 201, 301-305 (1986).
    [2] richter m, cloutier s, sirois p. endothelin, paf and thromboxane a2 in allergic pulmonary hyperreactivity in mice. prostaglandins leukot essent fatty acids. 2007 may;76(5):299-308.
9,11-DIDEOXY-9ALPHA,11ALPHA-EPOXY-METHANOPROSTAGLANDIN F2ALPHA Preparation Products And Raw materials
Raw materials
Preparation Products
9,11-DIDEOXY-9ALPHA,11ALPHA-EPOXY-METHANOPROSTAGLANDIN F2ALPHA Suppliers
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9,11-DIDEOXY-9ALPHA,11ALPHA-EPOXY-METHANOPROSTAGLANDIN F2ALPHA Spectrum
56985-32-1, 9,11-DIDEOXY-9ALPHA,11ALPHA-EPOXY-METHANOPROSTAGLANDIN F2ALPHARelated Search:
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Heterocycles
  • Chiral Reagents
  • BioChemical
  • Biochemicals and Reagents
  • Prostaglandins
  • Lipids
  • Fatty Acids
  • 9,11-双脱氧-9Α,11Α-环氧基甲烷前列腺素F2Α
  • 9,11-DIDEOXY-9Α,11Α-EPOXYMETHANOPROSTAGLANDIN F2Α
  • 56985-32-1
  • 5-Heptenoic acid, 7-[(1S,4R,5S,6R)-5-[(1E,3S)-3-hydroxy-1-octen-1-yl]-2-oxabicyclo[2.2.1]hept-6-yl]-, (5Z)-
  • DJKDIKIDYDXHDD-WKSHRDMKSA-N
  • (5Z)-7-[(1S,4R)-5α-[(1E,3S)-3-Hydroxy-1-octenyl]-2-oxabicyclo[2.2.1]heptan-6β-yl]-5-heptenoic acid
  • 9,11-epoxymethanoprostaglandin H(2)
  • 9,11-dideoxy-9α,11α-epoxymethanoprostaglandin f2α
  • 9,11-DIDEOXY-9A,11A-EPOXYMETHANO-PROSTAG LANDIN F2A
  • 9,11-dideoxy-9A,11A-epoxymethano-*prostaglandin F
  • 9,11-DIDEOXY-9ALPHA,11ALPHA-EPOXY-METHANOPROSTAGLANDIN F2ALPHA
  • 9,11-DIDEOXY-9ALPHA,11ALPHA-EPOXYMETHANO-PROSTA-5Z,13E-DIEN-1-OIC ACID
  • U-44069

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