8-ISO prostaglandin F2BeTa

Description

8-iso Prostaglandin F_2β (8-iso PGF_2β) is an isomer of PGF_2α with a non-enzymatic, non-cyclooxygenase origin. It is one of 64 possible isomers of PGF_2α which can be produced by free radical peroxidation of arachidonic acid. 8-iso PGF_2β exhibits very weak contraction of human umbilical vein artery and does not promote aggregation of human whole blood. However, 8-iso PGF_2β moderately contracts both the canine and porcine pulmonary vein, although the effect is much weaker than that exhibited by other isoprostanes such as 8-iso PGE₁, 8-iso PGE₂, or 8-iso PGF_2α

Uses

8-iso Prostaglandin F2β (8-iso PGF2β) is a biomarker for assessing oxidative stress, and its content in serum can indirectly reflect the level of oxidative stress[1].

References

[1] Shaker S R, Al-Amran F, Fatima G, et al. Trimetazidine improves the outcome of EECP therapy in patients with refractory angina pectoris[J]. Medical Archives, 2020, 74(3): 199.