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Nisoldipine

Nisoldipine Structure
Nisoldipine
  • CAS No.63675-72-9
  • Chemical Name:Nisoldipine
  • CBNumber:CB5147166
  • Molecular Formula:C20H24N2O6
  • Formula Weight:388.41
  • MOL File:63675-72-9.mol
Nisoldipine Property
  • Melting point 147-148°C
  • Boiling point 503.3±50.0 °C(Predicted)
  • Density 1.205±0.06 g/cm3(Predicted)
  • storage temp. room temp
  • solubility DMSO: >10mg/mL
  • pka 2.67±0.70(Predicted)
  • form powder
  • color yellow
  • Merck 14,6565
  • InChIKey VKQFCGNPDRICFG-UHFFFAOYSA-N
  • CAS DataBase Reference 63675-72-9(CAS DataBase Reference)
  • FDA UNII 4I8HAB65SZ
  • NIST Chemistry Reference Nisoldipine(63675-72-9)
  • ATC code C08CA07
  • UNSPSC Code 41116107
  • NACRES NA.77
Safety
  • Hazard Codes  :Xn
  • Risk Statements  :20/21/22
  • Safety Statements  :36
  • WGK Germany  :3
  • RTECS  :US7975600
  • HS Code  :2933399090
  • NFPA 704:
    0
    3 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302
  • Precautionary statements P264-P270-P301+P312-P501
Nisoldipine Price More Price(4)
  • Brand: Sigma-Aldrich(India)
  • Product number: N0165
  • Product name : Nisoldipine
  • Purity: ≥98% (HPLC)
  • Packaging: 10MG
  • Price: ₹8540.93
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: N0165
  • Product name : Nisoldipine
  • Purity: ≥98% (HPLC)
  • Packaging: 50MG
  • Price: ₹35289.5
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: N0900
  • Product name : Nisoldipine
  • Purity: 
  • Packaging: 1G
  • Price: ₹9700
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: N0900
  • Product name : Nisoldipine
  • Purity: 
  • Packaging: 5G
  • Price: ₹14500
  • Updated: 2022/05/26
  • Buy: Buy

Nisoldipine Chemical Properties,Usage,Production

  • Description Nisoldipine D4 is another long-acting dihydropyridine calcium channel blocker effective in the treatment of hypertension and angina pectoris. It is reported to have little or no cardiodepressive activity and to be more effective than nifedipine in reducing blood pressure in hypertensives. Nisoldipine has also been shown to be effective in the management of congestive heart failure. Reduction in dosage is necessary in patients with hepatic, but not renal impairment.
  • Chemical Properties Nisoldipine D4 is Light Tan Crystals
  • Originator Bayer AG (Germany)
  • Uses urease inhibitor
  • Uses Labeled Nisoldipine, intended for use as an internal standard for the quantification of Nisoldipine by GC- or LC-mass spectrometry.
  • Uses Dihydropyridine calcium channel blocker. Antihypertensive and antianginal
  • Definition ChEBI: A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a methoxycarbonyl group at position 3, an o-nitrophenyl group at position 4, and an isobutoxycarbonyl group at position 5. The racemate, calcium channel blocker, is used in the treatment of hypertension and angina pectoris.
  • Manufacturing Process Boiling a solution of 12.7 g of 2'-nitrobenzylideneacetoacetic acid methyl ester and 7.1 g of β-amino-crotonic acid isopropyl ester in 50 ml of methanol for 10 hours yielded 2,6-dimethyl-4-(2'-nitrophenyl)-1,4-dihydropyridine-3,5- dicarboxylic acid 3-methyl ester-5-isopropyl ester of melting point 174°C (from ethanol). Yield 48% of theory.
  • brand name Sular (Sciele);Baymycard.
  • Therapeutic Function Coronary vasodilator
  • General Description In vitro studies show that the effects ofnisoldipine, 1,4-dihydro-2, 6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinecarboxylic acid methyl 2-methylpropyl ester(Sular), on contractile processes are selective, with greaterpotency on vascular smooth muscle than on cardiac muscle.
    Nisoldipine is highly metabolized, with five majormetabolites identified. As with most of the dihydropyridines,the cytochrome P450 (CYP) 3A4 isozyme is mainlyresponsible for the metabolism of nisoldipine. The majorbiotransformation pathway appears to involve the hydroxylationof the isobutyl ester side chain. This particular metabolitehas approximately 10% of the activity of the parentcompound.
  • Biochem/physiol Actions L-type (CaV1.2) calcium channel blocker; dihydropyridine-type calcium channel blocker with selectivity for smooth muscle (CaV1.2b) over cardiac muscle (CaV1.2a). Arterial vasodilator and antihypertensive agent.
Nisoldipine Preparation Products And Raw materials
Raw materials
Preparation Products
Nisoldipine Suppliers
Global(385)Suppliers
  • Supplier：
    Henan Tianfu Chemical Co.,Ltd.
  • Tel：+86-0371-55170693<br/>+86-19937530512
  • Email：info@tianfuchem.com
  • Country：China
  • ProdList：21628
  • Advantage：55
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：sales@coreychem.com
  • Country：China
  • ProdList：29858
  • Advantage：58
Nisoldipine Spectrum
63675-72-9, NisoldipineRelated Search:
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Inhibitors
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  • Cardiovascular APIs
  • Calcium channel
  • 抑制剂
  • 化学试剂
  • 配体家族
  • 药靶配体
  • 医用原料
  • 医药原料药
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  • 其他原料药
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  • 医药原料药-科研原料
  • 对照品
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  • 医药中间体
  • 对照品,标准品
  • 抗高血压
  • 抗心绞痛药
  • C20H24N2O6
  • C20H18N2O6D6
  • 甲醇中尼索地平
  • 3-异丁基 5-甲基 2,6-二甲基-4-(2-硝基苯基)-1,4-二氢吡啶-3,5-二甲酸酯
  • 尼索地平/硝苯异丙啶
  • 3-异丁基 5-甲基 2,6-二甲基-4-(2-硝基苯基)-1,4-二氢吡啶-3,5-二羧酸酯
  • NISOLDIPINE 尼索地平
  • 尼索地平对照品
  • 尼索地平溶液,100PPM
  • 尼索地平(标准品)
  • 硝苯异丙啶
  • 尼索地平
  • 1,4-二氢-2,6-二甲基-4-(2-硝基苯)-3,5-吡啶二羧酸异丁甲酯
  • 2,6-二甲基-4-(2-硝基苯基)-1,4-二氢-3,5-吡啶二羧酸甲酯2-甲基丙酯
  • 63675-72-9
  • Nisoldipine - Bio-X ?
  • NISOLDIPINE NON STERILE BULK DRUG SUBSTANCE
  • 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid O3-methyl ester O5-(2-methylpropyl) ester
  • Nisoldipine(BAY-k 5552
  • hexakis(dihydrogen phosphate)
  • NisoldipineQ: What is Nisoldipine Q: What is the CAS Number of Nisoldipine Q: What is the storage condition of Nisoldipine Q: What are the applications of Nisoldipine
  • Nisoldipine USP/EP/BP
  • 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic Acid Isobutyl Methyl Ester

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