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10-Hydroxydecanoic acid

CAS No.1679-53-4
Chemical Name:10-Hydroxydecanoic acid
CBNumber:CB5146543
Molecular Formula:C10H20O3
Formula Weight:188.26
MOL File:1679-53-4.mol

10-Hydroxydecanoic acid Property

Melting point 75-77 °C (lit.)
Boiling point 330.8±15.0 °C(Predicted)
Density 1.013±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Slightly), Methanol (Slightly)
pka 4.78±0.10(Predicted)
form Solid
color White to Off-White
InChIKey YJCJVMMDTBEITC-UHFFFAOYSA-N
LogP 1.847 (est)
CAS DataBase Reference 1679-53-4(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII NP03XO416B
NIST Chemistry Reference 10-Hydroxydecanoic acid(1679-53-4)
UNSPSC Code 12352100
NACRES NA.22

Safety

Hazard Codes :Xi
WGK Germany :3
Hazard Note :Irritant
HS Code :2918199890

NFPA 704:

	0
0		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H302-H315-H319-H335
Precautionary statements P261-P305+P351+P338

10-Hydroxydecanoic acid Price More Price(2)

Brand: Sigma-Aldrich(India)
Product number: 379700
Product name : 10-Hydroxydecanoic acid
Purity: technical grade
Packaging: 500MG
Price: ₹7209.45
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 379700
Product name : 10-Hydroxydecanoic acid
Purity: technical grade
Packaging: 5G
Price: ₹30071.85
Updated: 2022/06/14
Buy: Buy

10-Hydroxydecanoic acid Chemical Properties,Usage,Production

Uses Reactant involved in: • ;Synthesis of copolymers of acrylamide and sodium acryloyloxydecanoate1• ;Macrolactonization for preparation of Sansalvamide A2• ;Studies of chain length selectivity for cutinase catalyzed polycondensation reactions3• ;Ruthenium-catalyzed esterification followed by macrocyclization4• ;Synthesis of anhydrides and esters5
Uses 10-Hydroxydecanoic acid is suitable for use in a study on Novozym 435-catalyzed condensation polymerization of cis-9,10-epoxy-18-hydroxyoctadecanoic acid and its comparison with corresponding polymerization of 10-hydroxydecanoic acid.
Definition ChEBI: A 10-carbon, omega-hydroxy fatty acid, shown to be the preferred hydroxylation product (together with the 9-OH isomer) of capric acid in biosystems, and used as a standard in lipid assays; reported to have cytotoxic effects.
General Description 10-Hydroxydecanoic acid (10-HDA) is a saturated fatty acid of hydroxy-trans-2-decenoic acid (10H2DA). Its molecule has two functional groups (-OH and -COOH). It has been reported to prevent the lipopolysaccharide-induced NO production in murine macrophages. 10-HDA has been extracted from royal jelly obtained from honeybees (Apis mellifera) and exhibits estrogenic action.Its polymerization with the polyethylene glycol-modified lipase in a transparent benzene solution has been reported to proceed by the formation of ester linkage.

in vivo

10-Hydroxydecanoic acid (1 mol/L; Intranasal injection 100 μL; once daily for 3 days) increases the number of microfold cells (M cells) in the epithelium lining the luminal surface of the nasopharyngeal-associated lymphoid tissue (NALT) in cynomolgus monkeys^[2]. 10-Hydroxydecanoic acid (2.4 mg; p.o.; enteric-coated capsules taken orally once a day for 20 days) increases the number of M cells and improves the level of antigen-specific immunoglobulin A (IgA) in the follicle-associated epithelium (FAE) covering Peyer’s patches (PPs) in cynomolgus monkeys^[2].

Animal Model:	cynomolgus macaque ^[2]
Dosage:	1 mol/L, Administer 100 μL
Administration:	Intranasal administration; once a day for 3 days
Result:	Increased number of gp2-positive cells in the epithelium overlying NALT follicles.

Animal Model:	cynomolgus macaque ^[2]
Dosage:	2.4 mg
Administration:	p.o.; enteric-coated capsules once a day for 20 days
Result:	Increased the number of gp2-positive M cells. 10-HDAA (2.4 mg) enteric-coated capsules containing poliovirus antigen (106 TCID50) induced poliovirus- and influenza virus-specific IgAs on day 12 after oral administration.