ChemicalBook CAS DataBase List 1679-53-4

1679-53-4

Name	10-Hydroxydecanoic acid
CAS	1679-53-4
EINECS(EC#)	216-848-1
Molecular Formula	C10H20O3
MDL Number	MFCD00010510
Molecular Weight	188.26
MOL File	1679-53-4.mol

Chemical Properties

Melting point	75-77 °C (lit.)
Boiling point	330.8±15.0 °C(Predicted)
density	1.013±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
pka	4.78±0.10(Predicted)
color	White to Off-White
InChIKey	YJCJVMMDTBEITC-UHFFFAOYSA-N
LogP	1.847 (est)
CAS DataBase Reference	1679-53-4(CAS DataBase Reference)
NIST Chemistry Reference	10-Hydroxydecanoic acid(1679-53-4)

Safety Data

Hazard Codes	Xi
WGK Germany	3
Hazard Note	Irritant
HS Code	2918199890

Raw materials And Preparation Products

Hazard Information

Uses

Reactant involved in: • ;Synthesis of copolymers of acrylamide and sodium acryloyloxydecanoate1• ;Macrolactonization for preparation of Sansalvamide A2• ;Studies of chain length selectivity for cutinase catalyzed polycondensation reactions3• ;Ruthenium-catalyzed esterification followed by macrocyclization4• ;Synthesis of anhydrides and esters5

Definition

ChEBI: A 10-carbon, omega-hydroxy fatty acid, shown to be the preferred hydroxylation product (together with the 9-OH isomer) of capric acid in biosystems, and used as a standard in lipid assays; reported to have cytotoxic effects.

General Description

10-Hydroxydecanoic acid (10-HDA) is a saturated fatty acid of hydroxy-trans-2-decenoic acid (10H2DA). Its molecule has two functional groups (-OH and -COOH). It has been reported to prevent the lipopolysaccharide-induced NO production in murine macrophages. 10-HDA has been extracted from royal jelly obtained from honeybees (Apis mellifera) and exhibits estrogenic action.Its polymerization with the polyethylene glycol-modified lipase in a transparent benzene solution has been reported to proceed by the formation of ester linkage.

in vivo

10-Hydroxydecanoic acid (1 mol/L; Intranasal injection 100 μL; once daily for 3 days) increases the number of microfold cells (M cells) in the epithelium lining the luminal surface of the nasopharyngeal-associated lymphoid tissue (NALT) in cynomolgus monkeys^[2]. 10-Hydroxydecanoic acid (2.4 mg; p.o.; enteric-coated capsules taken orally once a day for 20 days) increases the number of M cells and improves the level of antigen-specific immunoglobulin A (IgA) in the follicle-associated epithelium (FAE) covering Peyer’s patches (PPs) in cynomolgus monkeys^[2].

Animal Model:	cynomolgus macaque ^[2]
Dosage:	1 mol/L, Administer 100 μL
Administration:	Intranasal administration; once a day for 3 days
Result:	Increased number of gp2-positive cells in the epithelium overlying NALT follicles.

Animal Model:	cynomolgus macaque ^[2]
Dosage:	2.4 mg
Administration:	p.o.; enteric-coated capsules once a day for 20 days
Result:	Increased the number of gp2-positive M cells. 10-HDAA (2.4 mg) enteric-coated capsules containing poliovirus antigen (106 TCID50) induced poliovirus- and influenza virus-specific IgAs on day 12 after oral administration.

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