ChemicalBook > CAS DataBase List > Posatirelin

Posatirelin

Pharmacological Study

Posatirelin

Posatirelin Property

Hazard and Precautionary Statements (GHS)

Posatirelin Chemical Properties,Usage,Production

Pharmacological Study Posatirelin is a TRH analogue. In a rat experimental model of brain cholinergic deficit by lesion of the nucleus basalis magnocellularis (nbM), posatirelin treatment rescued cholinergic neurones of the nbM and their cholinergic projections to the cerebral cortex (Sabbatini et al., 1998). Posatirelin has been used in AD and VaD patients (Parnetti et al., 1995, 1996). VaD patients treated with posatirelin showed a significant improvement in intellectual performance, orientation, motivation and memory as compared to controls. The drug was well tolerated.
Description Posatirelin is a TRH analogue. In a rat experimental model of brain cholinergic decit by lesion of the nucleus basalis magnocellularis (nbM), posatirelin treatment rescued cholinergic neurones of the nbM and their cholinergic projections to the cerebral cortex (Sabbatini et al., 1998). Posatirelin has been used in AD and VaD patients (Parnetti et al., 1995, 1996). VaD patients treated with posatirelin showed a signicant improvement in intellectual performance, orientation, motivation and memory as compared to controls. e drug was well tolerated.
Uses Posatirelin is a thyrotropin-releasing hormone analogue, used in the treatment of seizures and some neurodegenerative disease such as vascular dementia and Parkinson''s disease.
Definition ChEBI: Posatirelin is an oligopeptide.
in vivo
Posatirelin (2 mg/kg, IP) increases the high-affinity Ca²⁺-ATPase in both 3- and 24-month-old hypoxic rats^[1].