78664-73-0

Name	Posatirelin
CAS	78664-73-0
Molecular Formula	C17H28N4O4
MDL Number	MFCD00865152
Molecular Weight	352.43
MOL File	78664-73-0.mol

Synonyms

RGH-2202 Posatirelin N-[(S)-6-Oxo-2-piperidinylcarbonyl]-L-Leu-L-Pro-NH2 N-[6-Oxopiperidin-2(S)-Ylcarbonyl]-L-Leucyl-L- Prolinamide

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Chemical Properties

Melting point	214-216°
alpha	D25 -80.2° (c = 1 in acetic acid)
Boiling point	739.6±60.0 °C(Predicted)
density	1.214±0.06 g/cm3(Predicted)
pka	13.56±0.20(Predicted)

Hazard Information

Description

Posatirelin is a TRH analogue. In a rat experimental model of brain cholinergic decit by lesion of the nucleus basalis magnocellularis (nbM), posatirelin treatment rescued cholinergic neurones of the nbM and their cholinergic projections to the cerebral cortex (Sabbatini et al., 1998). Posatirelin has been used in AD and VaD patients (Parnetti et al., 1995, 1996). VaD patients treated with posatirelin showed a signicant improvement in intellectual performance, orientation, motivation and memory as compared to controls. e drug was well tolerated.

Uses

Posatirelin is a thyrotropin-releasing hormone analogue, used in the treatment of seizures and some neurodegenerative disease such as vascular dementia and Parkinson''s disease.

Definition

ChEBI: Posatirelin is an oligopeptide.

in vivo

Posatirelin (2 mg/kg, IP) increases the high-affinity Ca²⁺-ATPase in both 3- and 24-month-old hypoxic rats^[1].

Questions And Answer

Pharmacological Study
Posatirelin is a TRH analogue. In a rat experimental model of brain cholinergic deficit by lesion of the nucleus basalis magnocellularis (nbM), posatirelin treatment rescued cholinergic neurones of the nbM and their cholinergic projections to the cerebral cortex (Sabbatini et al., 1998). Posatirelin has been used in AD and VaD patients (Parnetti et al., 1995, 1996). VaD patients treated with posatirelin showed a significant improvement in intellectual performance, orientation, motivation and memory as compared to controls. The drug was well tolerated.;

Spectrum Detail

Posatirelin(78664-73-0)¹HNMR

Supplier

Jiangsu Hongmin Pharmaceutical Co., Ltd.

Telephone18221292452

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList34013/0_EN.htm

Shanghai Yifei Biotechnology Co. , Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

Shanghai Amole Biotechnology Co., Ltd.

Telephone13370042665 18916960931

Websitehttps://www.amole.com.cn/

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