Description
(±)-N-3-Benzylnirvanol is a racemic mixture of (+)-N-3-benzylnirvanol and (–)-N-3-benzylnirvanol. (+)-N-3-benzylnirvanol and (–)-N-3-benzylnirvanol are inhibitors of the cytochrome P450 (CYP) isoform CYP2C19 (K
is = 0.25 and 5.3 μM, respectively). (±)-N-3-Benzylnirvanol (20 mg/kg, i.p.) lowers plasma levels of cholesterol in mice.
Chemical Properties
White Solid
Uses
It is a potent and selective human CYP2C19 inhibitor
References
[1] HISASHI SUZUKI. (+)-N-3-Benzyl-nirvanol and (-)-N-3-benzyl-phenobarbital: new potent and selective in vitro inhibitors of CYP2C19.[J]. Drug Metabolism and Disposition, 2002, 23 1: 235-239. DOI:
10.1124/dmd.30.3.235[2] JAMES H. MAGUIRE Iris H H Akula R Murthy. Hypolipidemic activity of antiepileptic 5-phenylhydantoins in mice[J]. European journal of pharmacology, 1985, 117 1: Pages 135-138. DOI:
10.1016/0014-2999(85)90483-2
