93879-40-4

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It is a potent and selective human CYP2C19 inhibitor

(±)-N-3-Benzylnirvanol is a racemic mixture of (+)-N-3-benzylnirvanol and (–)-N-3-benzylnirvanol. (+)-N-3-benzylnirvanol and (–)-N-3-benzylnirvanol are inhibitors of the cytochrome P450 (CYP) isoform CYP2C19 (K_is = 0.25 and 5.3 μM, respectively). (±)-N-3-Benzylnirvanol (20 mg/kg, i.p.) lowers plasma levels of cholesterol in mice.

[1] HISASHI SUZUKI. (+)-N-3-Benzyl-nirvanol and (-)-N-3-benzyl-phenobarbital: new potent and selective in vitro inhibitors of CYP2C19.[J]. Drug Metabolism and Disposition, 2002, 23 1: 235-239. DOI: 10.1124/dmd.30.3.235
[2] JAMES H. MAGUIRE  Iris H H  Akula R Murthy. Hypolipidemic activity of antiepileptic 5-phenylhydantoins in mice[J]. European journal of pharmacology, 1985, 117 1: Pages 135-138. DOI: 10.1016/0014-2999(85)90483-2