ChemicalBook > CAS DataBase List > (S)-2-ETHOXY-3-[4-[2-(4-METHANESULFONYLOXY-PHENYL)-ETHOXY]-PHENYL]-PROPIONIC ACID

(S)-2-ETHOXY-3-[4-[2-(4-METHANESULFONYLOXY-PHENYL)-ETHOXY]-PHENYL]-PROPIONIC ACID

(S)-2-ETHOXY-3-[4-[2-(4-METHANESULFONYLOXY-PHENYL)-ETHOXY]-PHENYL]-PROPIONIC ACID Structure
(S)-2-ETHOXY-3-[4-[2-(4-METHANESULFONYLOXY-PHENYL)-ETHOXY]-PHENYL]-PROPIONIC ACID
  • CAS No.251565-85-2
  • Chemical Name:(S)-2-ETHOXY-3-[4-[2-(4-METHANESULFONYLOXY-PHENYL)-ETHOXY]-PHENYL]-PROPIONIC ACID
  • CBNumber:CB5114898
  • Molecular Formula:C20H24O7S
  • Formula Weight:408.47
  • MOL File:251565-85-2.mol
(S)-2-ETHOXY-3-[4-[2-(4-METHANESULFONYLOXY-PHENYL)-ETHOXY]-PHENYL]-PROPIONIC ACID Property
  • Melting point 83-85°C
  • Boiling point 611℃
  • Density 1.278
  • Flash point 324℃
  • storage temp. 2-8°C
  • solubility Chloroform (Slightly), Methanol (Slightly)
  • form Solid
  • pka 3.62±0.10(Predicted)
  • color White
  • Merck 14,9177
  • FDA UNII 6734037O3L
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302
  • Precautionary statements P280-P305+P351+P338

(S)-2-ETHOXY-3-[4-[2-(4-METHANESULFONYLOXY-PHENYL)-ETHOXY]-PHENYL]-PROPIONIC ACID Chemical Properties,Usage,Production

  • Chemical Properties White Solid
  • Uses Dual -acting peroxisome proliferator-activated receptor (PPAR) a and agonist. Antidiabetic
  • Biological Activity Tesaglitazar is a potent and specific dual PPARα/γ agonist th at improves insulin resistance and carbohydrate and lipid metabolism in ob/ob mice and obese Zucker rats.
  • in vivo

    Tesaglitazar (0.3-10 μmol/kg; po; once daily; 104 weeks) induces subcutaneous stromal sarcomas (fibrosarcomas) in Wistar Hannover Galas rats, and also induces a variety of non-neoplastic changes, such as cardiac hypertrophy and liver changes[1].
    Tesaglitazar (1, 10 μmol/kg; po; once daily; 2 or 12 weeks) in Wistar Hannover Galas rats, sustained stimulation of DNA synthesis, increased BrdU-labeled cells[1].
    Tesaglitazar (50 nmol/kg; sc; once daily; 14 days) reduced body weight, food intake, fasting blood glucose and insulin levels, improved insulin sensitivity and glucose metabolism, and had no significant effect on renal function in the male C57BL/6J diet-induced obesity (DIO) mouse model[2].
    Tesaglitazar (5 or 100 nmol/kg; sc; single dose) induced an acute deterioration in glucose tolerance at a high dose (100 nmol/kg), but a low dose (5 nmol/kg) reduced body weight, food intake and fasting blood glucose levels and improved glucose tolerance[2] in the DIO mouse model[2].
    Tesaglitazar (10-20 μg/kg; intraperitoneal injection; single dose) significantly restored the mechanical paw withdrawal threshold (PWT) in the Streptozotocin (HY-13753)-induced diabetic neuropathy pain model in rats without affecting blood glucose levels[3].

    Animal Model:Wistar Hannover Galas rats (6-8 weeks old; carcinogenicity model)[1]
    Dosage:0.3, 1, 3, 10 μmol/kg (dissolved in 5mM sodium hydrogen carbonate buffer solution, pH 8.5)
    Administration:Oral gavage, once daily, 104 weeks
    Result:Induced subcutaneous mesenchymal sarcomas (fibrosarcomas) in both male and female rats (10 μmol/kg).
    Caused various non-neoplastic changes, such as myocardial hypertrophy, liver changes, and alterations in multiple organ systems.
  • storage Desiccate at RT
(S)-2-ETHOXY-3-[4-[2-(4-METHANESULFONYLOXY-PHENYL)-ETHOXY]-PHENYL]-PROPIONIC ACID Preparation Products And Raw materials
Raw materials
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(S)-2-ETHOXY-3-[4-[2-(4-METHANESULFONYLOXY-PHENYL)-ETHOXY]-PHENYL]-PROPIONIC ACID Spectrum
251565-85-2, (S)-2-ETHOXY-3-[4-[2-(4-METHANESULFONYLOXY-PHENYL)-ETHOXY]-PHENYL]-PROPIONIC ACIDRelated Search:
  • Sulfur & Selenium Compounds
  • Pharmaceuticals
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Drug Intermediates
  • 抑制剂
  • 生化试剂
  • 医药中间体
  • C20H24O7S
  • 替格列扎,10 MM DMSO 溶液
  • 化合物 T17044
  • 替格列扎
  • (S)-2-乙氧基-3-{4-[2-(4-甲磺酰基苯基)-乙氧基-苯基]-丙酸
  • (S)-2-乙氧基-3-[4-[2-(4-甲磺酰基氧基苯基)乙氧基]苯基]丙酸
  • 251565-85-2
  • Tesaglitazar, 10 mM in DMSO
  • (2S)-2-ethoxy-3-[4-[2-(4-methylsulfonyloxyphenyl)ethoxy]phenyl]propanoic acid
  • Tesaglitizar
  • Benzenepropanoic acid, α-ethoxy-4-[2-[4-[(methylsulfonyl)oxy]phenyl]ethoxy]-, (αS)-
  • 2-ethoxy-3-[4-[2-(4-methylsulfonyloxyphenyl)ethoxy]phenyl]propanoic acid
  • Galida
  • (aS)-α-Ethoxy-4-[2-[4-[(methylsulfonyl)oxy]phenyl]ethoxy]benzenepropanoic Acid
  • Benzenepropanoic acid, a-ethoxy-4-[2-[4-[(methylsulfonyl)oxy]phenyl]ethoxy]-, (aS)-
  • Galid
  • AZ 242
  • AR-H 039242XX
  • (aS)-a-Ethoxy-4-[2-[4-[(methylsulfonyl)oxy]phenyl]ethoxy]benzenepropanoic Acid
  • AR-H 039242
  • (S)-2-Ethoxy-3-[4-[2-(4-methanesulfonyloxyphenyl)ethoxy]phenyl]propanoic Acid
  • TESAGLITAZAR
  • (S)-2-ETHOXY-3-[4-[2-(4-METHANESULFONYLOXY-PHENYL)-ETHOXY]-PHENYL]-PROPIONIC ACID
  • Benzenepropanoic acid, .alpha.-ethoxy-4-[2-[4-[(methylsulfonyl)oxy]phenyl]ethoxy]-, (.alpha.S)-
  • (S)-2-Ethoxy-3-(4-(4-((Methylsulfonyl)oxy)phenethoxy)phenyl)propanoic acid
  • (S)-2-ethoxy-3-[4-(2-{4-Methanesulphonyloxyphenyl}ethoxy)phenyl]propanoic acid
  • (alphaS)-alpha-Ethoxy-4-[2-[4-[(methylsulfonyl)oxy]phenyl]ethoxy]benzenepropanoic acid
  • (αS)-α-Ethoxy-4-[2-[4-[(Methylsulfonyl)oxy]phenyl]ethoxy]benzenepropanoic Acid
  • 2-Ethoxy-3-{4-[2-(4-methanesulfonyloxy-phenyl)-ethoxy]-phenyl}-propionicacid

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