ChemicalBook > CAS DataBase List > 2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-4,5-diethyl-2,4-dihydro-3H-1,2,4-triazol-3-one monohydrochloride

2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-4,5-diethyl-2,4-dihydro-3H-1,2,4-triazol-3-one monohydrochloride

2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-4,5-diethyl-2,4-dihydro-3H-1,2,4-triazol-3-one monohydrochloride Structure
2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-4,5-diethyl-2,4-dihydro-3H-1,2,4-triazol-3-one monohydrochloride
  • CAS No.57775-22-1
  • Chemical Name:2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-4,5-diethyl-2,4-dihydro-3H-1,2,4-triazol-3-one monohydrochloride
  • CBNumber:CB4930927
  • Molecular Formula:C19H29Cl2N5O
  • Formula Weight:414.37246
  • MOL File:57775-22-1.mol
2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-4,5-diethyl-2,4-dihydro-3H-1,2,4-triazol-3-one monohydrochloride Property
  • Melting point 197-198°
  • solubility soluble in Methanol, Water
  • form Solid
  • color White
  • FDA UNII 2FSU2FR80J
Safety
  • Toxicity :LD50 in mice, rats (mg/kg): 580, 720 orally; 72, 62 i.v.; 135, 120 i.p. (Lisciani)
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-4,5-diethyl-2,4-dihydro-3H-1,2,4-triazol-3-one monohydrochloride Chemical Properties,Usage,Production

  • Chemical Properties White Solid
  • Originator Etoperidone,ZYF Pharm
  • Uses A psychotropic drug related structurally to trazodone. Antidepressant.
  • Manufacturing Process (a). 3,4-Diethyl-δ2-1,2,4-triazolin-5-one (62 g) is dissolved in anhydrous dioxane (about 500 ml) and NaH (21 g) in a 50 percent oily suspension is added. The solution is heated for 30 min under reflux and NmetachlorophenyI- N'-(3-chloro-n-propyl)piperazine (119 g) is added under stirring. The solution is heated for 20 hours under reflux. The solvent is then eliminated under reduced pressure and the residue is treated with 2 N HCl. The solution is washed with ether so as to eliminate the oil present in the hydride solution, and made alkaline with 50% K2CO3. It is extracted with ether and dried, the solvent is eliminated and the residue is distilled under reduced pressure. 115 g of 2-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)- 4,5-diethyl-2,4-dihydro-1,2,4-triazol-3-one are obtained. B.P. 230°C/0.5 mm.
    2-(3-(4-(3-Chlorophenyl)-1-piperazinyl)propyl)-4,5-diethyl-2,4-dihydro-1,2,4- triazol-3-one hydrochloride was prepared by standard procedures, melting point 197-198°C (recrystallization from isopropanol).
    (b). 3,4-Diethyl-δ2-1,2,4-triazolin-5-one (1 g) and 3-bromo-1-chloropropane (6.6 g) are added to a solution of Na (0.98 g) in methanol (20 ml). The solution is refluxed until the pH becomes neutral, poured into water, extracted with ether. The solvent is eliminated and the residual oil is distilled. 1-(3- Chloropropyl)-3,4-diethyl-δ2-1,2,4-triazolin-5-one boils at 121°C/0.05 mm.
    1-(3-Chloropropyl)-3,4-diethyl-δ2-1,2,4-triazolin-5-one (1.0 g), NmetachlorophenyIpiperazine (0.9 g) and triethylamine (0.46 g) in toluene (25 ml) are refluxed for 12 hours. The solution is treated with 5 N NaOH, extracted with ether and steam-distilled. The residue is extracted with ether and the ethereal solution is treated with ethereal HCl. 2-(3-(4-(3- Chlorophenyl)-1-piperazinyl)propyl)-4,5-diethyl-2,4-dihydro-1,2,4-triazol-3- one hydrochloride has melting point 197-198°C (recrystallization from isopropanol).
  • Therapeutic Function Antidepressant, Anxiolytic
2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-4,5-diethyl-2,4-dihydro-3H-1,2,4-triazol-3-one monohydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-4,5-diethyl-2,4-dihydro-3H-1,2,4-triazol-3-one monohydrochloride Suppliers
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2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-4,5-diethyl-2,4-dihydro-3H-1,2,4-triazol-3-one monohydrochloride Spectrum
57775-22-1, 2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-4,5-diethyl-2,4-dihydro-3H-1,2,4-triazol-3-one monohydrochlorideRelated Search:
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Heterocycles
  • Aromatics
  • 抑制剂
  • C19H29Cl2N5O
  • C19H28ClN5OHCl
  • 化合物 ETOPERIDONE HYDROCHLORIDE
  • 化合物 T24048
  • 盐酸曲唑酮杂质48
  • 盐酸曲唑酮杂质53
  • 盐酸依托哌酮
  • 57775-22-1
  • NSC-304398
  • NSC304398
  • NSC 304398
  • Trazodone Impurity 48
  • Trazodone Impurity 53
  • 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-4,5-diethyl-2,4-dihydro-3H-1,2,4-triazol-3-one monohydrochloride
  • Tropene
  • Staff
  • ST-1191
  • MCN-A-2673-11
  • Etoran
  • Depracer
  • Axiomin
  • Etonin
  • Deprecer
  • 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-4,5-diethyl-2,4-dihydro-3H-1,2,4-triazol-3-one Hydrochloride
  • 2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-4,5-diethyl-2,4-dihydro-3H-1,2,4-triazol-3-one monohydrochloride

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