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COLIVELIN

COLIVELIN Structure
COLIVELIN
  • CAS No.867021-83-8
  • Chemical Name:COLIVELIN
  • CBNumber:CB4795124
  • Molecular Formula:C119H206N32O35
  • Formula Weight:2645.15
  • MOL File:867021-83-8.mol
COLIVELIN Property
  • Density 1.42±0.1 g/cm3(Predicted)
  • storage temp. Store at -20°C
  • solubility insoluble in DMSO; insoluble in EtOH; ≥15 mg/mL in H2O
  • form solid
  • color White
  • Water Solubility Soluble to 1 mg/ml in 20% ethanol / water
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

COLIVELIN Chemical Properties,Usage,Production

  • Description Colivelin is a potent synthetic peptide activator of STAT3 that has neuroprotective activity. It protects approximately 50 and 100% of mouse primary cortical neurons from cell death induced by amyloid β (1-43) (Aβ43) when used at concentrations of 10 and 100 fM, respectively. Colivelin protects against cell death induced by V642I-APP in a CaM kinase IV (CaMKIV) and STAT3-dependent manner. It increases STAT3 phosphorylation in vitro and in vivo, an effect that correlates with improvements in working memory. Colivelin (10 pmol every six days) rescues deficits in spatial working memory in a mouse model of Alzheimer’s disease induced by intracerebroventricular injection of Aβ25-35. It also improves motor performance and prolongs survival in a mouse model of amyotrophic lateral sclerosis (ALS).
  • Uses Colivelin is a peptide that offers neuroprotective effects against Alzheimer''s Disease (AD). It is also an activator of STAT3, a transcription factor involved with the JAK2/STAT3 pathway. Aberration in this pathway is linked to the pathogenesis of AD. Neuroprotective product.
  • Mechanism of action Colivelin is a humanized peptide with neuroprotective effects that has a strong ability to fight against Aβ deposition, neuronal apoptosis, and synaptic plasticity defects in neurodegenerative diseases. Its neuroprotective pathway can be related to activating the STAT3 signaling pathway by inhibiting axonal damage and neuronal death in brain tissue. In addition, Colivelin may also occur through Ca2+/calmodulin-dependent protein kinase IV mediated by ADNF.
  • in vivo

    Colivelin (intracerebroventricular administration; 10 pmol/3 μl; 3 weeks) suppresses impairment in spatial working memory induced by repetitive intracerebroventricular injection of Aβ25-35 or Aβ1-42, in addition, it antagonizes neuronal loss in the CA1 region of hippocampus induced by hippocampal injection of Aβ1-42[1]. Colivelin (intraperitoneal administration; 1.4, 7, or 35 nM/0.21 mL; on the Y-maze testday) suppresses memory impairment caused by 3-quinuclidinyl benzilateand restricts functional memory deficit[1]. Colivelin (intraperitoneal injection; 1 mg/kg; 14 days) results in improved motor and cognitive function with time by performance of mNSS, rotarod, and corner turning test.It also reduces lesion volume and improves neurological deficits after MCAO[3].

    Animal Model:CD-1 mice[1]
    Dosage:10 pmol/3 μl
    Administration:Intracerebroventricular administration
    Result:Completely suppressed Aβ 25-35-mediated impairment in spatial working memory and increased the number of immunoreactive neurons.
    Animal Model:C57 mice[1]
    Dosage:1.4, 7, or 35 nM/0.21mL
    Administration:Intraperitoneal administration
    Result:Protected against cholinotoxin-induced amnesia in mice.
    Animal Model: Male C57BL/6 mice[3]
    Dosage:1 mg/kg
    Administration:Intraperitoneal administration
    Result:Protected against ischemic brain injury, and improves neurological outcomes
  • IC 50 STAT3; Amyloid-β
  • storage Store at -20°C
COLIVELIN Preparation Products And Raw materials
Raw materials
Preparation Products
COLIVELIN Suppliers
Global(107)Suppliers
  • Supplier：
    BOC Sciences
  • Tel：+1-631-485-4226
  • Email：inquiry@bocsci.com
  • Country：United States
  • ProdList：19552
  • Advantage：58
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：factory@coreychem.com
  • Country：China
  • ProdList：29808
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：
  • Email：support@targetmol.com
  • Country：United States
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  • Supplier：
    Nanjing TGpeptide
  • Tel：+86-13347807150<br/>+86-13347807150
  • Email：support@tgpeptide.com
  • Country：China
  • ProdList：3279
  • Advantage：58
COLIVELIN Spectrum
867021-83-8, COLIVELINRelated Search:
  • Amyloid beta-peptide and related
  • 医用原料
  • 抑制剂
  • 药靶配体
  • 多肽
  • 目录多肽
  • 目录肽
  • 标准品
  • 多肽中间体
  • C119H206N32O35
  • 神经肽COLIVELIN
  • SP-26 [COLIVELIN
  • 神经保护肽H-SER-ALA-LEU-LEU-ARG-SER-ILE-PRO-ALA-PRO-ALA-GLY-ALA-SER-ARG-LEU-LEU-LEU-LEU-THR-GLY-GLU-ILE-ASP-LEU-PRO-OH
  • L-丝氨酰-L-丙氨酰-L-亮氨酰-L-亮氨酰-L-精氨酰-L-丝氨酰-L-异亮氨酰-L-脯氨酰-L-丙氨酰-L-脯氨酰-L-丙氨酰甘氨酰-L-丙氨酰-L-丝氨酰-L-精氨酰-L-亮氨酰-L-亮氨酰-L-亮氨酰-L-亮氨酰-L-苏氨酰甘氨酰-L-ALPHA-谷氨酰-L-异亮氨酰-L-ALPHA-天冬
  • 科利维林
  • 867021-83-8
  • SALLRSIPAPAGASRLLLLTGEIDLP
  • Amyloid-β,β-amyloid peptide,STAT,Colivelin,Inhibitor,inhibit,disease,Neuroprotectant,Abeta,ischemic,brain,neurological,alzheimer,injury
  • Colivelin trifluoroacetate salt H-Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala-Pro-Ala-Gly-Ala-Ser-Arg-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro-OH trifluoroacetate salt
  • L-Proline, L-seryl-L-alanyl-L-leucyl-L-leucyl-L-arginyl-L-seryl-L-isoleucyl-L-prolyl-L-alanyl-L-prolyl-L-alanylglycyl-L-alanyl-L-seryl-L-arginyl-L-leucyl-L-leucyl-L-leucyl-L-leucyl-L-threonylglycyl-L-α-glutamyl-L-isoleucyl-L-α-aspartyl-L-leucyl-
  • SER-ALA-LEU-LEU-ARG-SER-ILE-PRO-ALA-PRO-ALA-GLY-ALA-SER-ARG-LEU-LEU-LEU-LEU-THR-GLY-GLU-ILE-ASP-LEU-PRO
  • Colivelin (human)
  • H-SER-ALA-LEU-LEU-ARG-SER-ILE-PRO-ALA-PRO-ALA-GLY-ALA-SER-ARG-LEU-LEU-LEU-LEU-THR-GLY-GLU-ILE-ASP-LEU-PRO-OH
  • COLIVELIN

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