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IBUFENAC

CAS No.1553-60-2
Chemical Name:IBUFENAC
CBNumber:CB4506742
Molecular Formula:C12H16O2
Formula Weight:192.25
MOL File:1553-60-2.mol

IBUFENAC Property

Melting point 85-87°C
Boiling point 288.25°C (rough estimate)
Density 1.0240 (rough estimate)
refractive index 1.5100 (estimate)
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility Chloroform (Slightly), Methanol (Slightly)
form Solid
pka 4.36±0.10(Predicted)
color White to Off-White
FDA UNII 5V4WIX44VI
UNSPSC Code 12352200
NACRES NA.77

Safety

HS Code :2916399090
Toxicity :LD50 orally in mice: 1.8 g/kg (Adams)

NFPA 704:

	0
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H302-H315-H319-H335
Precautionary statements P261-P305+P351+P338

IBUFENAC Chemical Properties,Usage,Production

Chemical Properties Crystalline Solid
Uses Used as an analgesic, anti-inflammatory.
Definition ChEBI: A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is replaced by a 4-isobutylphenyl group. Although it was shown to be effective in treatment of rheumatoid arthritis, the clinical use of ibufenac was discontinued due to hepatot xic side-effects.
Biological Activity ibufenac is a dual cox-1 and -2 inhibitor.cyclooxygenase (cox), also known as prostaglandin-endoperoxide synthase (ptgs), is an enzyme that is responsible for formation of prostanoids, such as thromboxane and prostaglandins.
in vitro ibufenac was identified as an analog of the nsaid ibuprofen that could inhibit cox-1 and -2 activity with ic50 values of 17.4 and 13.1 μm, respectively [1].
in vivo in a previous animal study, two new structural analogs, r3 and r4, along with their parent compounds, ibufenac and ibuprofen, were evaluated for their biopharmaceutical properties. aanti-inflammatory activity was evaluated by topically administering drugs to inhibit inflammation induced by using either clove oil or arachidonic acid. results showed that the rank order of activity was ibufenac approximately equal to ibuprofen > r3 approximately equal to r4 [2].
IC 50 17.4 and 13.1 μm for cox-1 and -2, respectively.
References [1] gülcan, h. o.,nlü, s.,dimoglo, a., et al. marginally designed new profen analogues have the potential to inhibit cyclooxygenase enzymes. arch.pharm.chem.life sci. 348, 55-61 (2015).
[2] rao cs, schoenwald rd, barfknecht cf, laban sl. biopharmaceutical evaluation of ibufenac, ibuprofen, and their hydroxyethoxy analogs in the rabbit eye. j pharmacokinet biopharm. 1992 aug;20(4):357-88.
[3] t. m. chalmers.