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(R)-(-)-IBUPROFEN

(R)-(-)-IBUPROFEN Structure
(R)-(-)-IBUPROFEN
  • CAS No.51146-57-7
  • Chemical Name:(R)-(-)-IBUPROFEN
  • CBNumber:CB3393273
  • Molecular Formula:C13H18O2
  • Formula Weight:206.29
  • MOL File:51146-57-7.mol
(R)-(-)-IBUPROFEN Property
  • Melting point 41-42°C
  • Boiling point 305.14°C (rough estimate)
  • Density 1.0176 (rough estimate)
  • refractive index 1.5290 (estimate)
  • storage temp. Sealed in dry,2-8°C
  • solubility Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
  • form White crystalline powder.
  • pka 4.41±0.10(Predicted)
  • color Colourless to Pale Beige Oil
  • Water Solubility 369.3mg/L(25 ºC)
  • FDA UNII 99W8H60N62
Safety
  • Safety Statements  :24/25
  • HS Code  :29155090
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P305+P351+P338

(R)-(-)-IBUPROFEN Chemical Properties,Usage,Production

  • Description Ibuprofen is a non-steroidal anti-inflammatory drug with diverse biochemical actions, most notably inhibiting COX-1 and COX-2 (IC50s = 2.6 and 1.53 μM, respectively). It is commonly synthesized as a racemic mixture of (S) and (R) isomers (Item No. item 70280). (R)-Ibuprofen is an enantiomer that is generally not considered a COX inhibitor and is instead thought to be involved in pathways of lipid metabolism as it is incorporated into triglycerides along with fatty acids. The (R) enantiomer can, however, inhibit NF-κB activation (IC50 = 121.8 μM) in response to T-cell stimulation as well as block superoxide formation, β-glucuronidase release, and LTB4 generation by stimulated neutrophils (IC50 values range from 40-100 μM). 50-60% of (R)-ibuprofen is inverted to (S)-ibuprofen in humans after oral administration.
  • Chemical Properties White Crystalline Solid
  • Uses A nonsteroidal anti-inflammatory drug (NSAID); activity resides primarily in the (S)-isomer.
  • Definition ChEBI: Levibuprofen is an ibuprofen. It is an enantiomer of a dexibuprofen.
  • Purification Methods Crystallise the (+) and (-) acids from EtOH or aqueous EtOH. The racemate which crystallises from pet ether with m 75-77o is sparingly soluble in H2O and has IR (film) 1705 (C=O), 2300—3700 (OH broad)cm-1. It is used as a non-steroidal anti-inflammatory. [Shiori et al. J Org Chem 43 2936 1978, Kaiser et al. J Pharm Sci 65 269 1976, J Pharm Sci 81 221 1992, Freer Acta Cryst (C) 49 1378 1993 for the (S+)-enantiomer.]
(R)-(-)-IBUPROFEN Preparation Products And Raw materials
Raw materials
Preparation Products
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(R)-(-)-IBUPROFEN Spectrum
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  • (R)-IbuprofenQ: What is (R)-Ibuprofen Q: What is the CAS Number of (R)-Ibuprofen Q: What is the storage condition of (R)-Ibuprofen Q: What are the applications of (R)-Ibuprofen
  • (R)-(-)-IBUPROFEN USP/EP/BP
  • Ibuprofen (R)-Isomer
  • (R)-(-)-ibuprofen reference substance
  • (R)-(-)-Ibuprofen ((R)-Ibuprofen)
  • (R)-(-)-Ibupr en
  • Ibuprofen Impurity 20((R)-Isomer)
  • levibuprofen
  • (alphaR)-alpha-Methyl-4-(2-methylpropyl)benzeneacetic acid
  • Benzeneacetic acid, a-Methyl-4-(2-Methylpropyl)-, (aR)-
  • (aR)-a-Methyl-4-(2-methylpropyl)benzeneacetic Acid
  • R-(-)-p-Isobutylhydratropic acid
  • l-Ibuprofen
  • Benzeneacetic acid, α-methyl-4-(2-methylpropyl)-, (αR)-
  • Benzeneacetic acid, α-methyl-4-(2-methylpropyl)-, (R)-
  • (-)-Ibuprophen
  • (R)-(-)-IBUPROFEN
  • (R)-(-)-2-(4-ISOBUTYLPHENYL)-PROPIONIC ACID

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