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DIF-3

DIF-3 Structure
DIF-3
  • CAS No.113411-17-9
  • Chemical Name:DIF-3
  • CBNumber:CB4498007
  • Molecular Formula:C13H17ClO4
  • Formula Weight:272.72
  • MOL File:113411-17-9.mol
DIF-3 Property
  • Boiling point 416.9±45.0 °C(Predicted)
  • Density 1.240±0.06 g/cm3(Predicted)
  • solubility DMSO: 46 mg/mL, soluble
  • form solid
  • pka 5.92±0.45(Predicted)
  • color White to off-white
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • WGK Germany  :3
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
DIF-3 Price More Price(1)
  • Brand: Sigma-Aldrich(India)
  • Product number: D0567
  • Product name : DIF-3
  • Purity: ≥99% (HPLC), solid
  • Packaging: 1MG
  • Price: ₹11745.13
  • Updated: 2022/06/14
  • Buy: Buy

DIF-3 Chemical Properties,Usage,Production

  • Uses DIF-3 has been used: as a glycogen synthase kinase-3β (GSK-3β) activator to determine if GSK-3β is required for the anti-inflammatory actions of VU0360172 (VuPAM) in murine microglia, as a phosphorylation inhibitor for GSK-3β to examine the links between activation of protein kinase B (PKB)/GSK-3β/Fyn axis and nuclear factor erythroid 2–related factor 2 (NRF2) retention, as a GSK3β activator to study its effects on the cyclooxygenase 2 (COX2) expression levels in human primary chondrocytes in response to visfatin, as a GSK3β activator to study its effects on the intracellular mechanics along with F-actin and β-tubulin fiber networks in human primary chondrocytes
  • Biological Activity Differentiation-inducing factor-3 (DIF-3) prevents the proliferation of intestinal cancer cells in vitro and in vivo. It may serve as a novel anti-cancer agent.', 'DIF-3 Inhibits cell cycle by inducing G0/G1 arrest.
  • in vivo

    DIF-3 (150 mg/kg; p.o.; once a day for 5 days/week over 4 weeks) inhibits oxidative stress (0.2% KBrO3)-induced tumors in Mutyh-/- mice[1].

    Animal Model:Mutyh-/- mice (KBrO3 dissolved in water at a concentration of 2 g/L was administered to 4-week-old mice for 12 weeks)[1]
    Dosage:150 mg/kg
    Administration:Oral gavage (p.o.); once a day for 5 days/week over 4 weeks
    Result:Markedly reduced the number of intestinal tumors, especially the number of large tumors with a diameter of >2.0 mm.
    No differences in the appearance, activity, body weight, or blood cell counts.
    The numbers of TCF7L2-and cyclin D1-positive nuclei in tumors were significantly decreased.
DIF-3 Preparation Products And Raw materials
Raw materials
Preparation Products
DIF-3 Suppliers
Global(20)Suppliers
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
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  • Advantage：58
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    Aladdin Scientific
  • Tel：
  • Email：tp@aladdinsci.com
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  • Supplier： Energy Chemical
  • Tel：021-58432009<br/>400-005-6266
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  • Supplier： Bide Pharmatech Ltd.
  • Tel：400-1647117<br/>13681763483
  • Email：product02@bidepharm.com
  • Country：China
  • ProdList：62072
  • Advantage：58
  • Supplier： TargetMol Chemicals Inc.
  • Tel： 4008200310
  • Email：marketing@tsbiochem.com
  • Country：China
  • ProdList：24642
  • Advantage：58
DIF-3 Spectrum
113411-17-9, DIF-3Related Search:
  • Organic Building Blocks
  • Ketones
  • D-DIF
  • Chemical Synthesis
  • Cell Biology
  • Carbonyl Compounds
  • C13 to C14
  • Building Blocks
  • Bioactive Small Molecules
  • 抑制剂
  • 化合物DIF-3,10 MM DMSO 溶液
  • 1-(3-氯-2,6-二羟基-4-甲氧基苯基)己烷-1-酮
  • 化合物 DIF-3
  • 113411-17-9
  • DIF-3, 10 mM in DMSO
  • 1-(3-Chloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one
  • DIF-3 >=99% (HPLC), solid
  • 1-Hexanone, 1-(3-chloro-2,6-dihydroxy-4-methoxyphenyl)-
  • 1-(3-Chloro-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone, Differentiation-inducing factor 3

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