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D-(+)-Maltose monohydrate

CAS No.6363-53-7
Chemical Name:D-(+)-Maltose monohydrate
CBNumber:CB4442570
Molecular Formula:C12H24O12
Formula Weight:360.31
MOL File:6363-53-7.mol

D-(+)-Maltose monohydrate Property

Melting point 119-121 °C (dec.)(lit.)
alpha 137 º (c=4, H2O, NH3)
bulk density 320kg/m3
storage temp. room temp
solubility H₂O: 50 mg/mL
form powder
color White
PH 5.0-7.0 (25℃, 0.5M in H2O)
optical activity [α]20/D +130±2°, 24 hr, c = 4% in H2O
biological source potato (tuber)
Water Solubility 1080 g/L (20 ºc)
λmax λ: 260 nm Amax: 0.08
λ: 280 nm Amax: 0.07
Merck 14,5714
BRN 5784659
CAS DataBase Reference 6363-53-7(CAS DataBase Reference)
FDA UNII DM477EE40D
NIST Chemistry Reference «beta»-Maltose monohydrate(6363-53-7)
UNSPSC Code 41116107
NACRES NA.79

Safety

Hazard Codes :Xi
Risk Statements :33-63-36/37/38
Safety Statements :24/25-36-26
WGK Germany :3
RTECS :OO5250000
F :3
TSCA :Yes
HS Code :17029010

NFPA 704:

	1
1		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H302-H315-H319-H335
Precautionary statements P261-P305+P351+P338

D-(+)-Maltose monohydrate Price More Price(33)

Brand: Sigma-Aldrich(India)
Product number: M9171
Product name : D-(+)-Maltose monohydrate
Purity: BioXtra, ≥99%
Packaging: 10MG
Price: ₹3830.4
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: PHR1497
Product name : Maltose Monohydrate
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 1G
Price: ₹11065.6
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: M9171
Product name : D-(+)-Maltose monohydrate
Purity: BioXtra, ≥99%
Packaging: 100G
Price: ₹11491.2
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: M9171
Product name : D-(+)-Maltose monohydrate
Purity: BioXtra, ≥99%
Packaging: 500G
Price: ₹24924.2
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: M5895
Product name : D-(+)-Maltose monohydrate
Purity: powder, BioReagent, suitable for cell culture, suitable for insect cell culture, ≥98%
Packaging: 500G
Price: ₹18660
Updated: 2022/06/14
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D-(+)-Maltose monohydrate Chemical Properties,Usage,Production

Chemical Properties Maltose occurs as white crystals or as a crystalline powder. It is odorless and has a sweet taste approximately 30% that of sucrose.
Chemical Properties White crystalline powder
Uses D-(+)-Maltose monohydrate, is commonly found in foods and commonly utilized in brewing processes. It is also used in various culture media in the cell and tissue culture applications. D-(+)-Maltose Monohydrate is used as a substrate for α-glucosidase. It is also used as a substrate for the identification, differentiation and characterization of enzymes such as maltase(s); maltose α-D-glucosyltransferase(s); maltose-transporting ATPase(s); maltose O-acetyltransferase(s) and maltose epimerase(s) and phosphorylase(s). D-Maltose is used to study maltose-binding proteins and disaccharide transport systems.
Uses D-Maltose, an α(1→4) linked disaccharide of D-glucose, is used as a substrate for the identification, differentiation and characterization of enzymes such as maltase(s); maltose α-D-glucosyltransferase(s); maltose-transporting ATPase(s); maltose O-acetyltransferase(s) and maltose epimerase(s) and phosphorylase(s). D-Maltose is used to study maltose-binding proteins and disaccharide transport systems.
Uses A disaccharide commonly found in foods and commonly utilized in brewing processes.
Production Methods Maltose monohydrate is prepared by the enzymatic degradation of starch.
General Description Maltose monohydrate is commonly used as a tablet filler or excipient in pharmaceutical industry.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pharmaceutical Applications Maltose is a disaccharide carbohydrate widely used in foods and pharmaceuticals. In parenteral products, maltose may be used as a source of sugar, particularly for diabetic patients.
Crystalline maltose is used as a direct-compression tablet excipient in chewable and nonchewable tablets.
Biochem/physiol Actions Maltose is a disaccharide containing two glucose molecules with an α(1→4) glycosidic linkage. Maltose can be derived from starch in food through the action of amylase. Maltose can be found in many food products, including beer, cereals, and pasta.
Safety Maltose is used in oral and parenteral pharmaceutical formulations and is generally regarded as an essentially nontoxic and nonirritant material. However, there has been a single report of a liver transplantation patient with renal failure who developed hyponatremia following intravenous infusion of normal immunoglobulin in 10% maltose. The effect, which recurred on each of four successive infusions, resembled that of hyperglycemia and was thought to be due to accumulation of maltose and other osmotically active metabolites in the extracellular fluid.
LD₅₀ (mouse, IV): 26.8 g/kg
LD₅₀ (mouse, SC): 38.6 g/kg
LD₅₀ (rabbit, IV): 25.2 g/kg
LD₅₀ (rat, IP): 30.6 g/kg
LD₅₀ (rat, IV): 15.3 g/kg
LD₅₀ (rat, oral): 34.8 g/kg
storage Maltose should be stored in a well-closed container in a cool, dry place.
Purification Methods Purify maltose by chromatography from aqueous solution on to a charcoal/Celite (1:1) column, wash it with water to remove glucose and other monosaccharides, then elute it with aqueous 75% EtOH. Crystallise it from water, aqueous EtOH or EtOH containing 1% nitric acid. Dry it as the monohydrate at room temperature under vacuum over H2SO4 or P2O5. Also purify it by dissolving it in MeOH, evaporating to a syrup which on standing for 12hours in contact with 1/10th its volume of H2O gives crystals of the monohydrate. Its iodine number is 55.5. The osazone has m 200o(dec) and [] D 20 +58o (c 1.4, H2O). [Howarth et al. J Chem Soc 793 1937, Beilstein 17 III/IV 3057, 17 V 189.]
Incompatibilities Maltose may react with oxidizing agents. A Maillard-type reaction may occur between maltose and compounds with a primary amine group, e.g. glycine, to form brown-colored products.
Regulatory Status In the USA, maltose is considered as a food by the FDA and is therefore not subject to food additive and GRAS regulations. Included in the FDA Inactive Ingredients Database (oral solutions). Included in the Canadian List of Acceptable Non-medicinal Ingredients. Included in parenteral products available in a number of countries worldwide.