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Acamprosate calcium

Acamprosate calcium Structure
Acamprosate calcium
  • CAS No.77337-73-6
  • Chemical Name:Acamprosate calcium
  • CBNumber:CB4310705
  • Molecular Formula:C10H20CaN2O8S2
  • Formula Weight:400.48
  • MOL File:77337-73-6.mol
Acamprosate calcium Property
  • Melting point >300°C
  • storage temp. 2-8°C
  • solubility H2O: >5mg/mL
  • form powder
  • color White to Off-White
  • Water Solubility Soluble in water (100mM)
  • Merck 14,17
  • CAS DataBase Reference 77337-73-6(CAS DataBase Reference)
  • FDA UNII 59375N1D0U
  • UNSPSC Code 41116107
  • NACRES NA.77
Safety
  • Hazard Codes  :Xi
  • Risk Statements  :36/37/38
  • Safety Statements  :26-36/37/39-36
  • WGK Germany  :3
  • RTECS  :TZ6357000
  • HS Code  :29241990
  • Toxicity :LD50 i.p. in male mice: 1.87 g/kg (Durlach, 1982)
  • NFPA 704:
    0
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319-H335
  • Precautionary statements P305+P351+P338-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
Acamprosate calcium Price More Price(3)
  • Brand: Sigma-Aldrich(India)
  • Product number: A6981
  • Product name : Acamprosate calcium
  • Purity: ≥98% (HPLC), powder
  • Packaging: 10MG
  • Price: ₹13834.35
  • Updated: 2022/06/14
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  • Brand: Sigma-Aldrich(India)
  • Product number: A6981
  • Product name : Acamprosate calcium
  • Purity: ≥98% (HPLC), powder
  • Packaging: 50MG
  • Price: ₹55369.88
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: A2359
  • Product name : Acamprosate Calcium
  • Purity: 
  • Packaging: 1G
  • Price: ₹14200
  • Updated: 2022/05/26
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Acamprosate calcium Chemical Properties,Usage,Production

  • Description Acamprosate is an acetylated derivative of the GABA analog homotaurine (tramiprosate; ). Despite its structural similarity to GABA, acamprosate does not act at GABAA receptors but does decrease paired-pulse inhibition of GABAA inhibitory post-synaptic currents (IPSCs) at short inter-stimulus intervals when used at a concentration of 300 μM, indicating that it may inhibit GABAB autoreceptor-mediated inhibition of GABA release. It is an NMDA receptor modulator with antagonist or agonist effects depending on brain region, receptor subunit composition, and other factors. Acamprosate (0.26 and 0.52 mmol/kg per day, i.p.) reduces voluntary intake of ethanol in rats, an effect that can be blocked by the GABA antagonist bicuculline . Formulations containing acamprosate have been used for the maintenance of alcohol abstinence.
  • Chemical Properties Acamprosate calcium is White Crystalline Solid
  • Originator Campral,Merck
  • Uses Of interest for the treatment of alcoholism. Store at -20°C
  • Uses glucocortcoid, antiinflammatory
  • Uses Acamprosate calcium is a synthetic amino acid and a neurotransmitter analogue that is used as an alcohol deterrent in management of alcohol dependence and abuse. Acamprosate calcium was approved for use in the therapy of alcohol dependence and abuse in the United States in 2004.
  • Uses Of interest for the treatment of alcoholism and other neurochemical disorders.
  • Definition ChEBI: Acamprosate calcium is an organic calcium salt. It contains an acamprosate(1-).
  • Manufacturing Process In a 4 liter flask provided with stirring means, a bromine funnel and a thermometer, 17.5% sodium hydroxide solution and aminopropanesulfonic acid (homotaurine) are added.
    After complete dissolution, at a temperature of between 25°-40°C, acetic anhydride are added so as not to exceed a temperature of between 30°-40°C. The mixture is then maintained at this temperature by heating for at least 1 h.
    The solution is then concentrated in vacuum, the residue is redissolved in 2.5 L of distilled water and the mixture is concentrated again. The residue is then dissolved in 1.6 L of distilled water, filtered, then concentrated almost completely. Drying is terminated in an oven in vacuum. A colorless crystalline powder of 3-acetylaminopropanesulfonate of sodium (sodium Nacetylhomotaurinate) is obtained.
    The 3-acetylaminopropanesulfonic acid may be produced by treatment of 3- acetylaminopropanesulfonate of sodium with hydrochloric acid.
    In practice it is usually used as calcium salt.
  • brand name Campral (Forest).
  • Therapeutic Function Psychotropic
  • Biological Activity GABA receptor agonist and modulator of glutamatergic systems. Reduces alcohol consumption in animal models of alcohol addiction.
  • Biochem/physiol Actions Acamprosate calcium is a GABA γ-aminobutyric acid agonist.
  • Clinical Use Maintenance of abstinence in alcohol dependence
  • Metabolism Acamprosate is excreted in the urine and is not metabolised significantly.
  • storage Room temperature (desiccate)
  • References 1. wilde m i, wagstaff a j. acamprosate. drugs, 1997, 53(6): 1038-1053.
Acamprosate calcium Preparation Products And Raw materials
Raw materials
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Acamprosate calcium Spectrum
77337-73-6, Acamprosate calciumRelated Search:
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  • C10H20N2O8S2Ca
  • C5H10Ca05NO4S
  • C10H20CaN2O8S2
  • 2C5H10NO4SCa
  • C5H10NO4S2Ca
  • 阿坎酸钙盐
  • 2R)-反式-N-BOC-1
  • 3-乙酰氨基丙烷-1-磺酸钙
  • 阿坎酸钙, GABA受体激动剂和谷氨酸能系统调节剂
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  • 77337-73-6
  • Acamprosate calcium salt - Bio-X ?
  • ACAMPROSATE CALCIUM USP
  • Calcium acanate
  • trans-N-Boc-1
  • 2R)-trans-N-Boc-1
  • Acamprosate Calcium (1000554)
  • TIANFU-CHEM Acamprosate calcium
  • Acamprosate-d6 Calcium Salt
  • Acamprosate calcium (Campral EC)
  • 3-Acetamido-1-propanesulfonic Acid Calcium Salt
  • N-Acetylhomotaurine Calcium
  • Acamprosate Calcium &gt
  • Acamprosate calcium, 98%, GABA receptor agonist and modulator of glutamatergic systems
  • calcium 3-acetamido-1-propanesulfonate
  • 3-(Acetylamino)-1-propanesulfonic acid calcium salt (2:1)
  • Calcium 3-Acetamido-1-propanesulfonate 3-Acetamido-1-propanesulfonic Acid Calcium Salt
  • Sobriol
  • CaMpral EC
  • CalciuM N-AcetylhoMotaurinate
  • CalciuM Bisacetyl HoMotaurine
  • CalciuM AcaMprosate
  • Aotal
  • AlcoMed
  • 3-(Acetylamino)-1-propanesulfonicacidhemicalciumsalt
  • Calcium acetylhomotaurinate
  • CaAOTA
  • Bis[3-(acetylamino)-1-propanesulfonic acid]calcium salt
  • ALAMPROSATECALCIUM
  • 3-(Acetylamino)-1-propanesulfonic Acid Calcium Salt, Calcium Acetylhomotaurine
  • 3-(ACETYLAMINO)-1-PROPANESULFONIC ACID CALCIUM SALT
  • ACAMPROSATE CALCIUMSALT

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