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Q-VD-OPh hydrate

Q-VD-OPh hydrate Structure
Q-VD-OPh hydrate
  • CAS No.1135695-98-5
  • Chemical Name:Q-VD-OPh hydrate
  • CBNumber:CB42652283
  • Molecular Formula:C26H25F2N3O6
  • Formula Weight:513.49
  • MOL File:1135695-98-5.mol
Q-VD-OPh hydrate Property
  • Boiling point 808.9±65.0 °C(Predicted)
  • Density 1.346±0.06 g/cm3 (20 ºC 760 Torr)
  • storage temp. -20°C
  • solubility DMSO: ≥14mg/mL
  • pka 3.92±0.19(Predicted)
  • form powder
  • color white to light brown
  • Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
  • InChIKey OOBJCYKITXPCNS-REWPJTCUSA-N
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • WGK Germany  :3
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P305+P351+P338
Q-VD-OPh hydrate Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: SML0063
  • Product name : Q-VD-OPh hydrate
  • Purity: ≥95% (HPLC)
  • Packaging: 1MG
  • Price: ₹25644.43
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: SML0063
  • Product name : Q-VD-OPh hydrate
  • Purity: ≥95% (HPLC)
  • Packaging: 5MG
  • Price: ₹103865.88
  • Updated: 2022/06/14
  • Buy: Buy

Q-VD-OPh hydrate Chemical Properties,Usage,Production

  • Description Q-VD-OPH is a broad-spectrum caspase inhibitor, blocking caspases-3, -7, -8, -9, -10, and -12 and inhibiting apoptosis when used at 10 μM. It more effectively inhibits apoptosis and is much less cytotoxic than Z-VAD-FMK and Boc-D-FMK . Q-VD-OPH can be used in vivo, where it has been shown to prevent ischemia-reperfusion injury-induced apoptosis. This compound, by broadly inhibiting caspases, also promotes the differentiation of leukemic blasts cells, suggesting an application in differentiation therapy of certain forms of cancer.
  • Uses An inhibitor that is used in Alzheimer’s studies relating to caspase-6, the cysteinyl protease involved in neurodegenerative conditions. As well it is an intermediate in the formation of Palinavir, a potent HIV protease inhibitor.
  • Uses Q-VD-OPh hydrate has been used:
    • as a pan-caspase inhibitor to prevent cell death in urothelial carcinoma cells (UCC)
    • to induce canonical caspase-dependent apoptosis in UC cells
    • to block caspase-3 and Poly (ADP-ribose) polymerase-1 (PARP-1)
    • to study the protective role of EspZ effector protein against apoptosis and necrosis in human epithelial cells

  • Biochem/physiol Actions Q-VD-OPh is a potent pan-caspase inhibitor that protects cells from capsase-dependent apoptosis. Q-VD-OPh has superior aqueous stability, cell permeability, and efficacy than FMK-based caspase inhibitors and displays no cytotoxic effects alone.
  • target caspase-1
  • storage +4°C
  • References 1) Caserta?et al.?(2003),?Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties; Apoptosis,?8?345 2) Braun?et al.?(2007),?Protection from brain damage and bacterial infection in murine stroke by the novel caspase-inhibitor Q-VD-OPH; Exp. Neurol.,?206?183 3) Rebbaa?et al.?(2003),?Caspase inhibition switches doxorubicin-induced apoptosis to senescence; Oncogene,?22?2805 4) Bulatovic?et al.?(2015),?Sublethal caspase activation promotes generation of cardiomyocytes from embryonic stem cells; PLoS One,?10?e0120176 5) Bailey?et al. (2017),?Augmented trophoblast cell death in preeclampsia can proceed via ceramide-mediated necroptosis;?Cell Death Dis.,?8?e2590
Q-VD-OPh hydrate Preparation Products And Raw materials
Raw materials
Preparation Products
Q-VD-OPh hydrate Suppliers
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Q-VD-OPh hydrate Spectrum
1135695-98-5, Q-VD-OPh hydrateRelated Search:
  • Apoptosis
  • 多肽
  • 药靶配体
  • 活性多肽
  • 抑制剂
  • C26H25F2N3O6xH2O
  • C26H25F2N3O6
  • 化合物Q-VD-OPH,10 MM DMSO 溶液
  • QVD-OPH,CASPASE抑制剂
  • QVD-OPH NEGATIVE CONTROL,CASPASE INHIBITORS
  • QVD-OPH,不可逆的广谱胱天蛋白酶抑制剂
  • Q-VD-OPH(不纯)
  • (S)-5-(2,6-二氟苯氧基)-3-((S)-3-甲基-2-(喹啉-2-甲酰胺)丁胺基)-4-氧代戊酸
  • (3S)-5-(2,6-二氟苯氧基)-3-[[(2S)-3-甲基-1-氧代-2-[(2-喹啉甲酰基)氨基]丁基]氨基]-4-氧代-戊酸
  • N-(2-喹啉基)缬氨酰-天门冬氨酰-(2,6-二氟苯氧基)甲基 酮 水合物
  • 1135695-98-5
  • Q-VD-OPH, 10 mM in DMSO
  • QVD-OPh, caspase inhibitor
  • QVD-OPh Negative control, caspase inhibitors
  • QVD-OPH,QVDOPH,inhibit,Caspase,Human immunodeficiency virus,Inhibitor,HIV,Q VD OPH
  • Pentanoic acid, 5-(2,6-difluorophenoxy)-3-[[(2S)-3-methyl-1-oxo-2-[(2-quinolinylcarbonyl)amino]butyl]amino]-4-oxo-, (3S)-
  • QVD-OPH;QUINOLINE-VAL-ASP-DIFLUOROPHENOXYMETHYLKETONE
  • Q-VD-OPh (QVD-OPH
  • CS-2734
  • Quinoline-Val-Asp-Difluorophenoxymethylketone)
  • (3S)-5-(2,6-Difluorophenoxy)-3-[[(2S)-3-methyl-1-oxo-2-[(2-quinolinylcarbonyl)amino]butyl]amino]-4-oxo-pentanoic acid hydrate
  • (3S)-5-(2,6-Difluorophenoxy)-3-[[(2S)-3-methyl-1-oxo-2-[(2-quinolinylcarbonyl)amino]butyl]amino]-4-oxo-pentanoic acid
  • Q-VD-OPh hydrate

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