Q-VD-OPH is a broad-spectrum caspase inhibitor, blocking caspases-3, -7, -8, -9, -10, and -12 and inhibiting apoptosis when used at 10 μM.
1,2 It more effectively inhibits apoptosis and is much less cytotoxic than Z-VAD-FMK (Item No.
14463) and Boc-D-FMK (Item No.
16118).
1,2 Q-VD-OPH can be used
in vivo, where it has been shown to prevent ischemia-reperfusion injury-induced apoptosis.
3,4 This compound, by broadly inhibiting caspases, also promotes the differentiation of leukemic blasts cells, suggesting an application in differentiation therapy of certain forms of cancer.
5