ChemicalBook > CAS DataBase List > ABT-888
ABT-888
- CAS No.912445-05-7
- Chemical Name:ABT-888
- CBNumber:CB42473798
- Molecular Formula:C13H16N4O
- Formula Weight:244.296
- MOL File:912445-05-7.mol
ABT-888 Property
- Melting point >173°C (dec.)
- storage temp. Refrigerator
- solubility Methanol (Slightly, Heated), THF (Slightly, Heated)
- form Colorless to white crystalline solid.
- color Off-White to Dark Yellow
- NCI Dictionary of Cancer Terms ABT-888
-
Symbol(GHS)
- Signal wordWarning
- Hazard statements H302-H317
- Precautionary statements P280-P305+P351+P338
ABT-888 Chemical Properties,Usage,Production
- Uses ABT-888 is a potent, orally bioavailable PARP-1/-2 inhibitor shown to potentiate DNA damaging agents. The ability to potentiate temozolomide (TMZ) and develop a biological marker for PARP inhibition was evaluated in vivo. Potent PARP inhibitor.
-
in vivo
The oral bioavailability of Veliparib is 56%-92% in mice, SD rats, beagle dogs, and cynomolgus monkeys after oral administration[1]. Veliparib (25 mg/kg, i.p.) can improve tumor growth delay in a NCI-H460 xenograft model. Combination with radiation, veliparib decreases the tumor vessel formation[3]. Veliparib reduces intratumor PAR levels by more than 95% at a dose of 3 and 12.5 mg/kg in A375 and Colo829 xenograft models and the suppression can be maintained over time[4].
- IC 50 PARP-2: 2.9 nM (Ki); PARP-1: 5.2 nM (Ki)
- storage Store at -20°C
ABT-888 Preparation Products And Raw materials
Raw materials
Preparation Products
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- VELIPARIB DIHYDROCHLORIDE,PARP-1和-2抑制剂
- 维利帕尼二盐酸盐|||ABT-888 DIHYDROCHLORIDE
- 维利帕尼双盐酸盐
- 维利帕尼盐酸盐(ABT-888)
- 13C,2H3,15N]-维利帕尼二盐酸盐
- 化合物VELIPARIB DIHYDROCHLORIDE
- PARP1和PARP2抑制剂
- 维利帕尼二盐酸盐
- 维利帕尼盐酸盐
- 2-[(2R)-2-甲基-2-吡咯烷基]-1H-苯并咪唑-4-甲酰胺二盐酸盐
- ABT 888二盐酸盐
- VELIPARIB (ABT-888)(二盐酸盐)
- 912445-05-7
- Veliparib dihydrochloride, 10 mM in DMSO
- (R)-2-(2-Methylpyrrolidin-2-yl)-1H-benzo[d]imidazole-7-carboxamide dihydrochloride
- Veliparibdihydrochloride/ABT-888
- ABT888(Veliparib HCL)
- ABT 888;ABT888
- ABT888(2HCl salt)
- Veliparib (ABT-888 hydrochloride)
- Willipani
- Veliparib dihydrochloride salt
- ABT-888 USP/EP/BP
- Veliparib HCl
- ABT 888 dihydrochloride - Veliparib dihydrochloride | A 861695 dihydrochloride
- ABT-88
- Veliparib dihydrochloride, >=98%
- (R)-2-(2-Methylpyrrolidin-2-yl)-1H-benzo[d]imidazole-4-carboxamide dihydrochloride
- 2-[(2R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide,dihydrochloride
- Veliparib 2HCl
- 2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benzimidazole-7-carboxamide dihydrochloride
- Veliparib (ABT-888) dihydrochloride
- 1H-Benzimidazole-7-carboxamide, 2-[(2R)-2-methyl-2-pyrrolidinyl]-, hydrochloride (1:2)
- (R)-2-(2-Methylpyrrolidin-2-yl)-1H-benimidazole-4-carboxamide dihydrochloride (VELIPARIB)
- 2-[(2S)-2-Methyl-2-pyrrolidinyl]-1H-benziMidazole-4-carboxaMide
- Veliparib hydrochloride
- ABT888 HCl
- ABT-888 dihydrochloride
- ABT-888(Veliparib dihydrochloride)
- Veliparib dihydrochloride
- 2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-4-carboxamide dihydrochloride
- 2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide,dihydrochloridesalt
- ABT-888
