ChemicalBook > CAS DataBase List > 4-AMINO-1,8-NAPHTHALIMIDE

4-AMINO-1,8-NAPHTHALIMIDE

4-AMINO-1,8-NAPHTHALIMIDE Structure
4-AMINO-1,8-NAPHTHALIMIDE
  • CAS No.1742-95-6
  • Chemical Name:4-AMINO-1,8-NAPHTHALIMIDE
  • CBNumber:CB0774002
  • Molecular Formula:C12H8N2O2
  • Formula Weight:212.2
  • MOL File:1742-95-6.mol
4-AMINO-1,8-NAPHTHALIMIDE Property
  • Melting point 360 °C
  • Boiling point 352.04°C (rough estimate)
  • Density 1.105 g/mL at 25 °C(lit.)
  • vapor pressure 0Pa at 25℃
  • refractive index 1.6000 (estimate)
  • storage temp. -20°C
  • solubility Soluble in DMSO
  • form Orange solid.
  • pka 9.53±0.20(Predicted)
  • color Yellow to brown
  • Water Solubility 354mg/L at 25℃
  • LogP 1.08
  • CAS DataBase Reference 1742-95-6
  • FDA UNII S529AR2S8B
  • EPA Substance Registry System 1H-Benz[de]isoquinoline-1,3(2H)-dione, 6-amino- (1742-95-6)
  • UNSPSC Code 12352204
  • NACRES NA.83
Safety
  • Hazard Codes  :Xi
  • Risk Statements  :36/37/38
  • Safety Statements  :26-37/39
  • WGK Germany  :3
  • RTECS  :DE4081000
  • TSCA  :Yes
  • HS Code  :29251995
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319-H335
  • Precautionary statements P261-P264-P271-P280-P302+P352-P305+P351+P338
4-AMINO-1,8-NAPHTHALIMIDE Price More Price(3)
  • Brand: Sigma-Aldrich(India)
  • Product number: A0966
  • Product name : 4-Amino-1,8-naphthalimide
  • Purity: 
  • Packaging: 20MG
  • Price: ₹15458.1
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: ALFA India
  • Product number: ALF-J64358-MC
  • Product name : 4-Amino-1,8-naphthalimide, 95%
  • Purity: 
  • Packaging: 100mg
  • Price: ₹9180
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: ALFA India
  • Product number: ALF-J64358-03
  • Product name : 4-Amino-1,8-naphthalimide, 95%
  • Purity: 
  • Packaging: 1g
  • Price: ₹27521
  • Updated: 2022/05/26
  • Buy: Buy

4-AMINO-1,8-NAPHTHALIMIDE Chemical Properties,Usage,Production

  • Description The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. 4-amino-1,8-Naphthalimide (4-ANI) is an inhibitor of PARP (IC50 = 180 nM). It blocks radiation-induced PARP in cancer cells, potentiating the cytotoxicity of γ-radiation, although it is not cytotoxic in the absence of radiation. 4-ANI is used to study the role of PARP activity in various cell systems.
  • Chemical Properties orange amorphous powder
  • Uses The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. 4-amino-1,8-Naphthalimide (4-ANI) is an inhibitor of PARP (IC50 = 180 nM). It blocks radiation-induced PARP in cancer cells, potentiating the cytotoxicity of γ-radiation, although it is not cytotoxic in the absence of radiation. 4-ANI is used to study the role of PARP activity in various cell systems.
  • Definition ChEBI: 4-amino-1,8-naphthalimide is a benzoisoquinoline and a dicarboximide.
  • Biochem/physiol Actions 4-Amino-1,8-naphthalimide sensitizes cells to radiation-induced cell damage and enhances the cytotoxicity of 1-methyl-3-nitro-1-nitrosoguanidine.
  • Enzyme inhibitor This PARP inhibitor (FW = 212.21 g/mol) is a strong inhibitor of NAD:ADP-ribosyltransferase or poly(ADP-ribose) polymerase (IC50 = 0.18 μM). In addition, 4-Amino-1,8-naphthalimide is a radiation sensitizer at non-toxic and low concentrations.
  • References [1]. schlicker a, peschke p, bürkle a, et al. 4-amino-1,8-naphthalimide: a novel inhibitor of poly(adp-ribose) polymerase and radiation sensitizer. int j radiat biol. 1999 jan;75(1):91-100.
    [2]. davar d1, beumer jh, hamieh l, et al. role of parp inhibitors in cancer biology and therapy. curr med chem. 2012;19(23):3907-21.
    [3]. banasik m, komura h, shimoyama m,et al. specific inhibitors of poly(adp-ribose) synthetase and mono(adp-ribosyl)transferase. j biol chem. 1992 jan 25;267(3):1569-75.
    [4]. issaeva n, thomas hd, djureinovic t, et al. 6-thioguanine selectively kills brca2-defective tumors and overcomes parp inhibitor resistance. cancer res. 2010 aug 1;70(15):6268-76.
4-AMINO-1,8-NAPHTHALIMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
4-AMINO-1,8-NAPHTHALIMIDE Suppliers
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4-AMINO-1,8-NAPHTHALIMIDE Spectrum
1742-95-6, 4-AMINO-1,8-NAPHTHALIMIDERelated Search:
  • Therapy Adjuncts
  • P to
  • Apoptosis and Cell Cycle
  • Antitumor Agents
  • PARP Poly(ADP-ribose) PolymeraseCancer Research
  • PARP InhibitorsEnzyme Inhibitors by Enzyme
  • PARP (Poly(ADP-Ribose) polymerase)
  • Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
  • 抑制剂
  • 药靶配体
  • 萘 蒽 苊 菎
  • Apoptosis and Cell Cycle
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience
  • PARP
  • PARP Regulators
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  • 1742-95-6
  • 4-amino-1,8-Naphthalimide, 10 mM in DMSO
  • 4-Aminonaphthalimide, PARP-1 inhibitor
  • Inhibitor,4amino1,8Naphthalimide,4-Aminonaphthalimide,PARP,inhibit,poly ADP ribose polymerase,4 amino 1,8 Naphthalimide
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  • TIMTEC-BB SBB003425
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  • 4-AMINO-1,8-NAPHTHALIMIDE
  • 4-ANI
  • 6-AMINO-BENZO[DE]ISOQUINOLINE-1,3-DIONE
  • dfp1
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  • 6-AMino-1H-benzo[de]isoquinoline-1,3(2H)-dione
  • 6-amino-1h-benz(de)isoquinoline-1,3(2h)-dione
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  • 6-amino-1h-benz[de]isoquinoline-3(2h)-dione
  • 6-amino-1h-benz(de)isoquinoline-3(2h)-dione
  • 4-Amino-1,8-naphthalimide,98%
  • 6-Amino-2H-benzo[de]isoquinoline-1,3-dione
  • 6-Amino-2,3-dihydro-1H-benzo[de]isoquinoline-1,3-dione
  • 4-Aminonaphthalene-1,8-dicarbimide
  • 4-Amino-1,8-naphthalenedicarboximide
  • 4-Amino-1,8-naphthalenedicarbimide

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