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BENPROPERINE

BENPROPERINE Structure
BENPROPERINE
  • CAS No.2156-27-6
  • Chemical Name:BENPROPERINE
  • CBNumber:CB4187277
  • Molecular Formula:C21H27NO
  • Formula Weight:309.45
  • MOL File:2156-27-6.mol
BENPROPERINE Property
  • Boiling point bp0.2 159-161°
  • Density 1.0350 (rough estimate)
  • refractive index 1.5614 (estimate)
  • solubility DMSO:1.0(Max Conc. mg/mL);3.23(Max Conc. mM)
    PBS (pH:7.2):1.0(Max Conc. mg/mL);3.23(Max Conc. mM)
  • pka 9.46±0.50(Predicted)
  • FDA UNII 3AA6IZ48YK
  • ATC code R05DB02
Safety
  • Toxicity :LD50 orally in mice: 1087 mg/kg (Tellini, De Fina)
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

BENPROPERINE Chemical Properties,Usage,Production

  • Originator Tussafug,Medipharm,Switz.
  • Definition ChEBI: 1-[1-[2-(phenylmethyl)phenoxy]propan-2-yl]piperidine is a diarylmethane.
  • Manufacturing Process A mixture of 26.1 g of o-benzylphenoxy-β-chloropropane and 17 g of piperidine is refluxed over a period of 32 hours until the temperature is about 124°C and a nearly solid mixture is formed due to the precipitation of a salt. The mixture is then refluxed over a period of 48 hours at about 160°C and the reaction product obtained is cooled and dissolved in methanol. The solution is concentrated under reduced pressure to yield an oil which is added to 200 ml 3N hydrochloric acid whereupon the mixture is shaken with ether, 3 x 100 ml, until the aqueous phase is clear. The ether solution is washed with water, 3 x 50 ml, and the water present in the combined aqueous phase and water used for washing is evaporated under reduced pressure methanol being added three times when the residue appears to be dry. The impure hydrochloride of o-benzylphenoxy-β-N-piperidinopropane, 41 g, obtained is dissolved in 100 ml water and 100 ml 30% aqueous sodium hydroxide solution are added, whereupon precipitated oil is extracted with ether, 1 x 100 and 2 x 50 ml. The ether solution is washed with water, 4 x 50 ml, dried with magnesium sulfate and the ether is removed under reduced pressure. The residue, 25.2 g, is distilled under reduced pressure and the main fraction, 23.2 g, BP 159°-161°C/0.2 mm.
  • Therapeutic Function Antitussive
BENPROPERINE Preparation Products And Raw materials
Raw materials
Preparation Products
BENPROPERINE Suppliers
Global(39)Suppliers
  • Supplier：
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    TargetMol Chemicals Inc.
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    Chongqing Chemdad Co., Ltd
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BENPROPERINE Spectrum
2156-27-6, BENPROPERINERelated Search:
  • 抑制剂
  • 医药原料
  • 镇咳药物
  • 156-27-6
  • 化合物 BENPROPERINE
  • 化合物 T5007L
  • 磷酸苯哌丙烷
  • 咳快好
  • 苯丙哌林
  • 2156-27-6
  • Benproperine Monomer
  • BRN-1258822
  • BRN 1258822
  • Benproperinum
  • Bemproperina
  • BENPROPERINE USP/EP/BP
  • 1-[1-Methyl-2-[(α-phenyl-o-tolyl)oxy]ethyl]piperidine
  • 1-(2-Benzylphenoxy)-2-piperidinopropane
  • Piperidine, 1-[1-methyl-2-[2-(phenylmethyl)phenoxy]ethyl]-
  • Piperidine, 1-[1-methyl-2-[(a-phenyl-o-tolyl)oxy]ethyl]- (7CI, 8CI)
  • 1-[2-(2-Benzylphenoxy)-1-methylethyl]piperidine
  • Benproperin
  • pirexyl
  • 1-(2-(2-benzilfenossi)-1-metiletil)-piperidina
  • 1-(1-methyl-2-(2-(phenylmethyl)phenoxy)ethyl)-piperidin
  • 1-(1-methyl-2-((alpha-phenyl-o-tolyl)oxy)ethyl)piperidine
  • 1-(1-methyl-2-((alpha-phenyl-o-tolyl)oxy)ethyl)-piperidin
  • BENPROPERINE

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