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Diisobutylaluminium hydride

CAS No.1191-15-7
Chemical Name:Diisobutylaluminium hydride
CBNumber:CB4171924
Molecular Formula:C8H19Al
Formula Weight:142.22
MOL File:1191-15-7.mol

Diisobutylaluminium hydride Property

Melting point -70 °C
Boiling point 65 °C
Density 1.23 g/mL at 25 °C
vapor pressure 13.3Pa at 90℃
Flash point 40 °F
storage temp. 2-8°C
solubility Miscible with organic solvents.
form Solution
Specific Gravity 0.860
color Clear
Water Solubility vigorous reaction
Hydrolytic Sensitivity 8: reacts rapidly with moisture, water, protic solvents
Sensitive Air Sensitive/Heat Sensitive
BRN 4123663
Exposure limits ACGIH: TWA 20 ppm
OSHA: Ceiling 300 ppm; TWA 200 ppm
NIOSH: IDLH 500 ppm; TWA 100 ppm(375 mg/m3); STEL 150 ppm(560 mg/m3)
InChIKey AZWXAPCAJCYGIA-UHFFFAOYSA-N
LogP 4.22
CAS DataBase Reference 1191-15-7(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII H2EJ47H11A
NIST Chemistry Reference Diisobutylaluminum hydride(1191-15-7)
EPA Substance Registry System Diisobutylaluminum hydride (1191-15-7)
UNSPSC Code 12352001
NACRES NA.22

Safety

Hazard Codes :F,T,C,N
Risk Statements :14/15-17-35-40-67-65-63-48/20-11-34-19-62-51/53-23/24/25-20/21/22-15-14-50/53-37-22
Safety Statements :26-43-45-62-46-36/37/39-29-16-61-27-9
RIDADR :UN 3399 4.3/PG 1
WGK Germany :2
RTECS :BD0710000
F :1-4.3-10
TSCA :Yes
HazardClass :4.3
PackingGroup :I
HS Code :29319090
Hazardous Substances Data :1191-15-7(Hazardous Substances Data)

NFPA 704:

	3
0		3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H225-H250-H260-H304-H314-H336-H361d-H373-H412
Precautionary statements P210-P231+P232-P280-P301+P310+P331-P301+P330+P331-P303+P361+P353-P305+P351+P338+P310-P370+P378

Diisobutylaluminium hydride Price More Price(19)

Brand: Sigma-Aldrich(India)
Product number: 215007
Product name : Diisobutylaluminum hydride solution
Purity: 1.0?M in toluene
Packaging: 100ML
Price: ₹8649.18
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: 215007
Product name : Diisobutylaluminum hydride solution
Purity: 1.0?M in toluene
Packaging: 4X25ML
Price: ₹9590.95
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 215007
Product name : Diisobutylaluminum hydride solution
Purity: 1.0?M in toluene
Packaging: 800ML
Price: ₹40344.78
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: 214981
Product name : Diisobutylaluminum hydride solution
Purity: 1.0?M in THF
Packaging: 100ML
Price: ₹7090.38
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 214981
Product name : Diisobutylaluminum hydride solution
Purity: 1.0?M in THF
Packaging: 4X25ML
Price: ₹8584.23
Updated: 2022/06/14
Buy: Buy

Diisobutylaluminium hydride Chemical Properties,Usage,Production

Description Diisobutylaluminium hydride (DIBALH, DIBAL, DIBAL-H or DIBAH) is a reducing agent with the formula (i-Bu2AlH)2, where i-Bu represents isobutyl (-CH2CH(CH3)2). It can be used for various homogeneous reductions such as alkynes to alkenes, esters or nitriles to aldehydes. It is available commercially as the neat reagent and as a solution in several different solvents (hexane, dichloromethane, tetrahydrofuran, etc.). The neat reagent is a liquid and is supplied in metal cylinders. It is pyrophoric and highly reactive and therefore must be handled with great care. The molar solutions in organic solvents are more stable and easier to handle provided that the normal precautions are taken for working with air-sensitive compounds. They must all be handled in an atmosphere free from oxygen and water. Commonly used solvents for diisobutylaluminium hydride are dichloromethane, diglyme, dioxane and tetrahydrofuran. Even when the substrate is not completely soluble in these solvents successful reductions can be accomplished.
Chemical Properties Diisobutylaluminium hydride, also known as Dibal. colorless liquid. Viscosity 18.0mPa-s(25℃). Reacts violently with water to form hydrogen and isobutane. Tetrahydrofuran is not suitable as Dibal solvent, because the two react to produce coordination compounds. Diisobutylaluminium hydride is a useful reducing agent in organic synthesis. It can reduce ketones, carboxylic acids and esters to the corresponding alcohols. Dibal can also reduce lactones to o-hydroxy lactones.
Uses Diisobutylaluminum hydride is used as reducing agent in pharmaceuticals. It is also used as raw material in organic synthesis, agrochemicals and dyestuffs.
Uses Diisobutylaluminum hydride (DIBAL-H) is a common reducing agent to reduce aldehydes, ketones, esters, acids and acid chlorides to the corresponding alcohols. Some of the applications are:
Synthesis of α-acetoxy ethers by reduction and subsequent acetylation of esters.
Synthesis of coniferyl, sinapyl, and p-coumaryl alcohol by selective reduction of corresponding cinnamate esters.
Reduction of secondary phosphine oxides (SPOs) to the corresponding phosphines.
DIBAL-H can also be used in the hydroalumination of alkene and alkynes.
Uses Diisobutylaluminum hydride is commonly used as a reducing agent in organic synthesis.
Diisobutylaluminum hydride can be used in the following protocols:
As a promotor of Tishchenko reaction of aldehydes.
Conversion of benzylidene acetals of 1,2-and 1,3-glycols to the corresponding monobenzyl ethers of the glycols.
To generate a novel chiral reducing agent based on (S)-proline for the asymmetric reduction of prochiral ketones.
Flammability and Explosibility Spontaneously flammable in air (pyrophoric)
reaction suitability reagent type: reductant
Safety Profile Mddly toxic by inhalation. Dangerous fire hazard; iptes spontaneously in air. To fight fire, do not use water, foam, or halogenated extinguisking agents. See also HYDRIDES and ALUMINUM COMPOUNDS.