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AMINOPURVALANOL A

AMINOPURVALANOL A Structure
AMINOPURVALANOL A
  • CAS No.220792-57-4
  • Chemical Name:AMINOPURVALANOL A
  • CBNumber:CB4164371
  • Molecular Formula:C19H26ClN7O
  • Formula Weight:403.91
  • MOL File:220792-57-4.mol
AMINOPURVALANOL A Property
  • Boiling point 639.0±65.0 °C(Predicted)
  • Density 1.40±0.1 g/cm3(Predicted)
  • storage temp. Store at +4°C
  • solubility Soluble to 100 mM in DMSO
  • form White to brownish solid.
  • pka 14.51±0.10(Predicted)
  • color Off-white to light yellow
  • UNSPSC Code 12352200
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319-H335
  • Precautionary statements P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501

AMINOPURVALANOL A Chemical Properties,Usage,Production

  • Uses Aminopurvalanol A is a reversible and ATP-competitive inhibitor of Cdks.
  • Definition ChEBI: Aminopurvalanol is a purvalanol and a member of monochlorobenzenes. It has a role as a protein kinase inhibitor.
  • Biological Activity Cell-permeable cyclin-dependent kinase inhibitor. IC 50 values are 0.033, 0.033, 0.028 and 0.020 μ M for cdk1/cyclin B, cdk2/cyclin A, cdk2/cyclin E, and cdk5/p35 respectively. Inhibits ERK1 (IC 50 = 12.0 μ M) and ERK2 (IC 50 = 3.1 μ M) and is 3000-fold selective over a range of other protein kinases (IC 50 > 100 μ M). Arrests cell cycle at G 2 /M boundary (IC 50 = 1.25 μ M), and induces apoptosis at concentrations > 10 μ M.
  • Enzyme inhibitor This cell-permeable purvalanol derivative (FW = 403.92 g/mol), also named (2R)-2-[[6-[(3-Amino-5-chlorophenyl)amino]-9-(1-methylethyl)- 9H-purin-2-yl]amino]-3-methyl-1-butanol, targets cdk1/cyclin B (IC50 = 0.033 μM), cdk2/cyclin A (IC50 = 0.033 μM), cdk2/cyclin E (IC50 = 0.028 μM), and cdk5/p35 (IC50 = 0.020 μM). It also inhibits ERK1 (IC50 = 12 μM) and ERK2 (IC50 = 3.1 μM), with 3000-times greater selectivity versus a range of other protein kinases (IC50 > 100 μM). Aminopurvalanol A arrests cell cycle at G2/M boundary (IC50 = 1.25 μM), and induces apoptosis at concentrations > 10 μM.
  • storage Store at +4°C
AMINOPURVALANOL A Preparation Products And Raw materials
Raw materials
Preparation Products
AMINOPURVALANOL A Suppliers
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AMINOPURVALANOL A Spectrum
220792-57-4, AMINOPURVALANOL ARelated Search:
  • 化学试剂
  • 抑制剂
  • 合成有机化合物配体
  • C19H26ClN7O
  • 化合物AMINOPURVALANOL A,10 MM DMSO 溶液
  • AMINOPURVALANOL A,CYCLIN-DEPENDENT KINASE抑制剂
  • (R)-2-((6-(((3-氨基-5-氯苯基)氨基)-9-异丙基-9H-9H-PURIN-2-基)氨基)-3-甲基丁基-1-醇
  • (R)-2-((6-((3-氨基-5-氯苯基)氨基)-9-异丙基-9H-嘌呤-2-基)氨基)-3-甲基丁-1-醇
  • 化合物AMINOPURVALANOL A
  • 220792-57-4
  • Aminopurvalanol A, 10 mM in DMSO
  • Aminopurvalanol A, cyclin-dependent kinase inhibitor
  • inhibit,actin polymerization,Inhibitor,Cyclins,cancer cell differention,G2/M-phase transition,Apoptosis,Aminopurvalanol A,Cyclin dependent kinase,CDK,sperm fertilizing ability
  • (R)-2-((6-((3-Amino-5-chlorophenyl)amino)-9-isopropyl-9H-purin-2-yl)amino)-3-methylbutan-1-ol
  • 1-Butanol, 2-[[6-[(3-amino-5-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-, (2R)-
  • AMINOPURVALANOL A (APURV)
  • (2R)-2-[[6-[(3-AMINO-5-CHLOROPHENYL)AMINO]-9-(1-METHYLETHYL)-9H-PURIN-2-YL]AMINO]-3-METHYL-1-BUTANOL
  • AMINOPURVALANOL A
  • NG-97

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