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OLOMOUCINE

OLOMOUCINE Structure
OLOMOUCINE
  • CAS No.101622-51-9
  • Chemical Name:OLOMOUCINE
  • CBNumber:CB0309080
  • Molecular Formula:C15H18N6O
  • Formula Weight:298.34
  • MOL File:101622-51-9.mol
OLOMOUCINE Property
  • Melting point 120-130 °C
  • Boiling point 579.6±60.0 °C(Predicted)
  • Density 1.36
  • storage temp. -20°C
  • solubility DMSO, Methanol (Slightly)
  • form Solid
  • pka 14.55±0.10(Predicted)
  • color White to off-white
  • CAS DataBase Reference 101622-51-9(CAS DataBase Reference)
  • FDA UNII 6A839B2HYS
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • Safety Statements  :24/25
  • WGK Germany  :3
  • HS Code  :29339980
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319-H335
  • Precautionary statements P261-P271-P280
OLOMOUCINE Price More Price(4)
  • Brand: Sigma-Aldrich(India)
  • Product number: O0886
  • Product name : Olomoucine
  • Purity: ≥98% (HPLC)
  • Packaging: 1MG
  • Price: ₹8887.33
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: O0886
  • Product name : Olomoucine
  • Purity: ≥98% (HPLC)
  • Packaging: 5MG
  • Price: ₹32702.33
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 495620
  • Product name : Olomoucine - CAS 101622-51-9 - Calbiochem
  • Purity: A purine derivative that acts as a potent, reversible and selective inhibitor of p34cdk1/cyclin B and related kinases.
  • Packaging: 1MG
  • Price: ₹5880
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 495620
  • Product name : Olomoucine - CAS 101622-51-9 - Calbiochem
  • Purity: A purine derivative that acts as a potent, reversible and selective inhibitor of p34cdk1/cyclin B and related kinases.
  • Packaging: 5MG
  • Price: ₹22650
  • Updated: 2022/06/14
  • Buy: Buy

OLOMOUCINE Chemical Properties,Usage,Production

  • Chemical Properties white to off-white solid
  • Uses A purine derivative which inhibits cyclin-dependent kinases and induces G1 arrest.
  • Definition ChEBI: Olomoucine is a 9H-purine that is substituted by a (2-hydroxyethyl)nitrilo, benzylnitrilo and a methyl group at positions 2,6 and 9, respectively. It is a cyclin-dependent kinase inhibitor. It has a role as an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor. It is a member of 2,6-diaminopurines and a member of ethanolamines.
  • Biological Activity Cyclin-dependent kinase inhibitor that competes for the ATP binding site of the kinase. Selectively inhibits cdc2/cyclin B (IC 50 = 7 μ M), cdk2/cyclin A (IC 50 = 7 μ M), cdk2/cyclin E (IC 50 = 7 μ M), cdk/p35 kinase (IC 50 = 3 μ M)? and ERK1/MAP kinase (IC 50 = 25 μ M). Arrests human fibroblasts in the G1 phase.
  • Biochem/physiol Actions Olomoucine is a purine derivative which inhibits cyclin-dependent kinases and induces G arrest.
  • Enzyme inhibitor This ATP site-competitive purine derivative (FW = 298.35 g/mol; CAS 101622-51-9), systematically named 6-benzylamino-2-[2-hydroxyethylamino]- 9-methylpurine, is a potent inhibitor of cyclin-dependent kinases, with an IC50 value of 7 μM for both cdk1 and cdk2 and an IC50 value of 3 μM for cdk5, arresting cells in G1. Olomoucine also inhibits cytokinin 7b-glucosyltransferase.
  • References [1]. vesel j, havlicek l, strnad m, et al. inhibition of cyclin-dependent kinases by purine analogues. eur j biochem. 1994 sep 1;224(2):771-86.
    [2]. abraham rt, acquarone m, andersen a, et al. cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases. biol cell. 1995;83(2-3):105-20.
    [3]. tian ds, xie mj, yu zy, et al. cell cycle inhibition attenuates microglia induced inflammatory response and alleviates neuronal cell death after spinal cord injury in rats. brain res. 2007 mar 2;1135(1):177-85.
OLOMOUCINE Preparation Products And Raw materials
Raw materials
Preparation Products
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OLOMOUCINE Spectrum
101622-51-9, OLOMOUCINERelated Search:
  • Protein Kinase
  • Nucleotides
  • inhibitor
  • Inhibitors
  • Heterocycles
  • Bases & Related Reagents
  • Heterocyclic Compounds
  • 抑制剂
  • 小分子API
  • BioChemical
  • Apoptosis and Cell Cycle
  • Cell Biology
  • Cell Cycle
  • Cell Cycle Regulators
  • Cell Signaling and Neuroscience
  • C15H18N6O
  • 化合物OLOMOUCINE,10 MM DMSO 溶液
  • OLOMOUCINE,ATP-COMPETITIVE CDK抑制剂
  • 2-((6-(苄基氨基)-9-甲基-9H-嘌呤-2-基)氨基)乙醇
  • 化合物OLOMOUCINE
  • 奥罗莫星
  • 2-(2'-羟基乙基氨基)-9-甲基-6-(苄基氨基)嘌呤
  • 101622-51-9
  • Olomoucine, 10 mM in DMSO
  • Olomoucine, ATP-competitive CDK inhibitor
  • Olomoucine,Inhibitor,cyclindependent kinases,cdc2,purines,cell cycle,non-small cell lung cancer cell line,MR6.5,protein kinases,Cyclin dependent kinase,CDK,xenopus laevis oocytes,proliferation,inhibit,cdk2
  • 5-Bromo-21-fluorobenzylamine&hydrochloride
  • Ethanol, 2-[[9-methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-
  • 2-((6-(Benzylamino)-9-methyl-9H-purin-2-yl)amino)ethanol
  • Olomoucine - CAS 101622-51-9 - Calbiochem
  • NSC 666096
  • 2-(6-Benzylamino-9-methyl-9H-purin-2-ylamino)-ethanol Olomoucine
  • Olomoucine6-Benzylamino-2-(2-hydroxyethylamino)-9-methylpurine
  • Olomoucine,98%,high purity
  • N-(2-Hydroxyethyl)-N'-benzyl-9-methyl-9H-purine-2,6-diamine
  • 2-[[9-Methyl-6-(benzylamino)-9H-purine-2-yl]amino]ethanol
  • 2-[(2-Hydroxyethyl)amino]-6-benzylamino-9-methyl-9H-purine
  • Olomoucine,highpurity
  • OLOMOUCINE SYNTHETIC >95%
  • OLOMOUCINE
  • N2-[(2-HYDROXYETHYL)]-N6-BENZYLADENINE
  • 2-(2-HYDROXYETHYLAMINO)-6-BENZYLAMINO-9-METHYLPURINE
  • 2-[[9-METHYL-6[(PHENYLMETHYL)AMINO]-9H-PURIN-2-YL]AMINO]-ETHANOL
  • 2-(hydroxyethylamino)-6-benzylamino-9-methylpurine
  • 2-(2'-Hydroxyethylamino)-9-methyl-6-(benzylamino)purine
  • 6-BENZYLAMINO-2-(2-HYDROXYETHYLAMINO)-9-METHYLPURINE
  • 6-BENYLAMINO-2-(2-HYDROXYETHYLAMINO)-9-METHYLPURINE

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