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KARANJIN

CAS No.521-88-0
Chemical Name:KARANJIN
CBNumber:CB4134736
Molecular Formula:C18H12O4
Formula Weight:292.29
MOL File:521-88-0.mol

KARANJIN Property

Melting point 156°C
Boiling point 463.0±45.0 °C(Predicted)
Density 1.36
storage temp. 2-8°C
solubility Acetone (Slightly), Chloroform (Slightly), Methanol (Slightly)
form Solid
Specific Gravity 1.495
color White to Off-White
LogP 3.290 (est)
FDA UNII WV7IM0I02M
UNSPSC Code 41116107
NACRES NA.24

Safety

RTECS :DX1500000

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H335-H332-H312-H315-H302-H319
Precautionary statements P264-P270-P301+P312-P330-P501-P280-P302+P352-P312-P322-P363-P501-P261-P271-P304+P340-P312-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P

KARANJIN Chemical Properties,Usage,Production

Chemical Properties Needle-shaped crystal, soluble in methanol, ethanol, DMSO and other organic solvents, derived from water yellow skin, water Luo umbrella, water flow bean Pongamia pinnata, Mori fish vine Derris mollis. .
Uses Aquaxanthin has an anti-tuberculosis effect.
Definition ChEBI: Karanjin is an extended flavonoid.
Biological Activity Karanjin is the main active furanoflavonol component in Fordia cauliflora. It induces GLUT4 translocation in skeletal muscle cells by increasing AMPK, and induces cancer cell death through cell cycle arrest and promotes apoptosis.

in vivo

Karanjin (50, 100 mg/kg, p.o., 6 h) reduces the blood glucose level of Streptozotocin (HY-13753)-induced diabetic rats^[1].
Karanjin (20 mg/kg/d, p.o., 21 d) reduces joint injury and cartilage damage along with edema and erythema in the AIA model rats^[1].
Karanjin (10, 20 mg/kg/d, p.o., 14 d) significantly decreases serum ACP, ALP and TNFα levels in the AIA model rats ^[1].
Karanjin (25 or 50 mg/kg/d, p.o. or i.g., 8 d) improved learning and memory in Diazepam-induced amnesia mice^[1].

Animal Model:	Streptozotocin-induced diabetic rats^[1]
Dosage:	50, 100 mg/kg
Administration:	Oral gavage (p.o.), wait for 6h
Result:	Lowered the blood glucose level by 11.7% and 20.7% at 50 and 100 mg/kg gavage.

Animal Model:	Adjuvant induced arthritis model (AIA) Wistar strain male albino rats^[1]
Dosage:	10, 20 mg/kg/d
Administration:	Oral gavage (p.o.), 14 d for serum assay, 21 d for histological examination
Result:	Reduced articular cartilage damage, cellular infiltration in the articular cartilage and spongy bone damage significantly. Decreased serum acid phosphatase, alkaline phosphatase levels and TNFα level markedly.

Animal Model:	Diazepam-induced male swiss albino mice ^[1]
Dosage:	25, 50 mg/kg/d
Administration:	Oral gavage (p.o.) or Intraperitoneal injection (i.p.) for 8 d
Result:	Decreased the transfer latency on all the observation days, significantly reversed diazepam-induced amnesia, indicating improved learning and memory in treated mice.

KARANJIN Preparation Products And Raw materials

Raw materials

Preparation Products

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