ChemicalBook CAS DataBase List 521-88-0

521-88-0

Name	KARANJIN
CAS	521-88-0
EINECS(EC#)	208-319-9
Molecular Formula	C18H12O4
MDL Number	MFCD00017406
Molecular Weight	292.29
MOL File	521-88-0.mol

Chemical Properties

Melting point	156°C
Boiling point	463.0±45.0 °C(Predicted)
density	1.36
storage temp.	Sealed in dry,2-8°C
solubility	Acetone (Slightly), Chloroform (Slightly), Methanol (Slightly)
form	Solid
color	White to Off-White
Specific Gravity	1.495
Major Application	food and beverages
InChI	InChI=1S/C18H12O4/c1-20-18-15(19)13-7-8-14-12(9-10-21-14)17(13)22-16(18)11-5-3-2-4-6-11/h2-10H,1H3
InChIKey	LKPQNZRGGNOPPU-UHFFFAOYSA-N
SMILES	C1(C2=CC=CC=C2)OC2C3C=COC=3C=CC=2C(=O)C=1OC
LogP	3.290 (est)

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H335-H332-H312-H315-H302-H319
Precautionary statements	P264-P270-P301+P312-P330-P501-P280-P302+P352-P312-P322-P363-P501-P261-P271-P304+P340-P312-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
WGK Germany	WGK 3
RTECS	DX1500000
Storage Class	11 - Combustible Solids

Hazard Information

Chemical Properties

Needle-shaped crystal, soluble in methanol, ethanol, DMSO and other organic solvents, derived from water yellow skin, water Luo umbrella, water flow bean Pongamia pinnata, Mori fish vine Derris mollis. .

Uses

Aquaxanthin has an anti-tuberculosis effect.

Definition

ChEBI: Karanjin is an extended flavonoid.

Biological Activity

Karanjin is the main active furanoflavonol component in Fordia cauliflora. It induces GLUT4 translocation in skeletal muscle cells by increasing AMPK, and induces cancer cell death through cell cycle arrest and promotes apoptosis.

in vivo

Karanjin (50, 100 mg/kg, p.o., 6 h) reduces the blood glucose level of Streptozotocin (HY-13753)-induced diabetic rats^[1].
Karanjin (20 mg/kg/d, p.o., 21 d) reduces joint injury and cartilage damage along with edema and erythema in the AIA model rats^[1].
Karanjin (10, 20 mg/kg/d, p.o., 14 d) significantly decreases serum ACP, ALP and TNFα levels in the AIA model rats ^[1].
Karanjin (25 or 50 mg/kg/d, p.o. or i.g., 8 d) improved learning and memory in Diazepam-induced amnesia mice^[1].

Animal Model:	Streptozotocin-induced diabetic rats^[1]
Dosage:	50, 100 mg/kg
Administration:	Oral gavage (p.o.), wait for 6h
Result:	Lowered the blood glucose level by 11.7% and 20.7% at 50 and 100 mg/kg gavage.

Animal Model:	Adjuvant induced arthritis model (AIA) Wistar strain male albino rats^[1]
Dosage:	10, 20 mg/kg/d
Administration:	Oral gavage (p.o.), 14 d for serum assay, 21 d for histological examination
Result:	Reduced articular cartilage damage, cellular infiltration in the articular cartilage and spongy bone damage significantly. Decreased serum acid phosphatase, alkaline phosphatase levels and TNFα level markedly.

Animal Model:	Diazepam-induced male swiss albino mice ^[1]
Dosage:	25, 50 mg/kg/d
Administration:	Oral gavage (p.o.) or Intraperitoneal injection (i.p.) for 8 d
Result:	Decreased the transfer latency on all the observation days, significantly reversed diazepam-induced amnesia, indicating improved learning and memory in treated mice.

Spectrum Detail

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