Description
Dioxapyrrolomycin, a tricyclic pyrrole-containing antibiotic
isolated first from Streptomyces fumanus Sveshnikova
in the mid-1980s, displays moderate insecticidal
and acaricidal activity, but systematic structural changes
led to novel synthetic pyrrole derivatives with increased
insecticidal activity and mammalian safety (40). The natural
product and its synthetic congeners are uncouplers of
mitochondrial oxidative phosphorylation.
Uses
Pyrroxamycin is a novel antibiotic produced by Streptomyces, whose chemical structure was determined by chemical properties and X-ray crystallography and 13C NMR spectroscopy analysis. It is active against Gram-positive bacteria and dermatophytes. In this paper, the authors discuss the taxonomy, fermentation, isolation, physicochemical properties, chemical structure, and biological activity of the strain producing Pyrroxamycin.
Definition
ChEBI: Pyrroxamycin is a benzodioxine.
References
[1] Pyrroxamycin, a new antibiotic taxonomy, fermentation, isolation, structure determination and biological properties
