105888-54-8

Dioxapyrrolomycin, a tricyclic pyrrole-containing antibiotic isolated first from Streptomyces fumanus Sveshnikova in the mid-1980s, displays moderate insecticidal and acaricidal activity, but systematic structural changes led to novel synthetic pyrrole derivatives with increased insecticidal activity and mammalian safety (40). The natural product and its synthetic congeners are uncouplers of mitochondrial oxidative phosphorylation.

ChEBI: Pyrroxamycin is a benzodioxine.