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iopronic acid

iopronic acid Structure
iopronic acid
  • CAS No.37723-78-7
  • Chemical Name:iopronic acid
  • CBNumber:CB3922729
  • Molecular Formula:C15H18I3NO5
  • Formula Weight:673.02
  • MOL File:37723-78-7.mol
iopronic acid Property
  • Melting point 130°C
  • Boiling point 674.2±55.0 °C(Predicted)
  • Density 2.0615 (estimate)
  • pka 4.28±0.10(Predicted)
  • Water Solubility 20.08g/L(37 ºC)
  • FDA UNII 4P675153BV
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

iopronic acid Chemical Properties,Usage,Production

  • Originator Bilimiru,Bracco,Italy,1974
  • Uses Diagnostic aid (radiopaque medium, cholecystographic).
  • Definition ChEBI: Iopronic acid is an aromatic amide.
  • Manufacturing Process ,A solution of 192 g 3-acetylamino-2,4,6-triiodophenol, sodium (0.35 mol) in 350 ml dimethylacetamide, was mixed with 107.5 g 3-(2-iodoethoxy)-2- ethylpropionic acid ethyl ester (0.35 mol) at 90°C with stirring over a period of about 20 to 30 minutes. Stirring was continued while the mixture was held at 95°C to 100°C for 16 hours. The solvent was then removed by distillation in a vacuum, and the residue was poured into 4,000 ml water. The solid precipitate formed was recovered and washed with water, dilute sodium carbonate solution, dilute sodium bisulfite solution, and again with much water. The ethyl ester was obtained in a yield of 220 g (90%). When recrystallized from 75% aqueous ethanol, it melted at 80°C to 86°C.
    The ester (70 g, 0.1 mol) was saponified in a boiling mixture of 250 ml methanol and 250 ml water to which 100 ml N sodium hydroxide solution was added in small batches with stirring. The methanol was distilled from the saponification mixture, the residue was mixed with water and extracted with ethyl acetate. The aqueous phase was acidified with hydrochloric acid in the presence of sodium bisulfite.
    The free acid gradually crystallized from the acidified solution in the amount of42.4 g (63% yield). When recrystallized from 50% ethanol and from ethyl acetate, it melted at 130°C.
  • brand name Bilimiro (Bracco Industria Chimica S.p.A., Italy); Bilimiron (Bracco Industria Chimica S.p.A., Italy); Oravue (Bristol-Myers Squibb); Videobil (Bracco Industria Chimica S.p.A., Italy).
  • Therapeutic Function Diagnostic aid (radiopaque medium)
iopronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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iopronic acid Spectrum
37723-78-7, iopronic acidRelated Search:
  • 碘普罗酸
  • 37723-78-7
  • Butanoic acid, 2-[[2-[3-(acetylamino)-2,4,6-triiodophenoxy]ethoxy]methyl]-
  • Bilimiron
  • Bilimiro
  • B-11420
  • 2-[[2-[3-(Acetylamino)-2,4,6-triiodophenoxy]ethoxy]methyl]butyric acid
  • 2-[[2-[3-(Acetylamino)-2,4,6-triiodophenoxy]ethoxy]methyl]butanoic acid
  • lopronic
  • lopronic acid
  • iopronic acid

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