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Iodixanol

Iodixanol Structure
Iodixanol
  • CAS No.92339-11-2
  • Chemical Name:Iodixanol
  • CBNumber:CB6465056
  • Molecular Formula:C35H44I6N6O15
  • Formula Weight:1550.18
  • MOL File:92339-11-2.mol
Iodixanol Property
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
Iodixanol Price More Price(1)
  • Brand: Sigma-Aldrich(India)
  • Product number: PHR3015
  • Product name : Iodixanol
  • Purity: pharmaceutical secondary standard, certified reference material
  • Packaging: 500MG
  • Price: ₹20643.28
  • Updated: 2022/06/14
  • Buy: Buy

Iodixanol Chemical Properties,Usage,Production

  • Chemical Properties White Solid
  • Originator OptiPrep,Nycomed Pharma,Norway
  • Uses Nonionic, dimeric x-ray contrast medium. Diagnostic aid (radiopaque medium).
  • Definition ChEBI: A dimeric, non-ionic, water-soluble, radiographic contrast agent, used particularly in coronary angiography.
  • Manufacturing Process Dimethyl 5-nitroisophthalate (215 g) and 1-amino-2,3-propandiol (196 g)were refluxed in methanol (500 ml). After twenty hours the solution was cooled and stored in a refrigerator overnight. The product 5-nitro-N,N'- bis(2,3-dihydroxypropyl)-isophthalamide was filtered and washed with methanol. Yield: 270 g (84%). M.p. 128-132°C.
    5-Nitro-N,N'-bis(2,3-dihydroxypropyl)-isophthalamide (18.1 g) was suspended in water (250 ml), conc. hydrochloric acid (4.2 ml) and 10% PdO/charcoal (0.5 g) were added, and the mixture hydrogenated in a Parr apparatus for one day. After filtration the filtrate was heated at 80-90°C and 3.88 M NaICl2 (42.5 ml) was added through a dropping funnel over 1 hour. The solution was heated for 2.5 hours. After cooling to 20°C 5-amino-2,4,6-triiodo-N,N'- bis(2,3-dihydroxypropyl)-isophthalamide crystallized out.
    5-Amino-2,4,6-triiodo-N,N'-bis(2,3-dihydroxypropyl)-isophthalamide (110 g) was suspended in acetic anhydride (480 ml) and heated to 50°C. Concentrated sulfuric acid (3 ml) was then added. The starting material was dissolved after a few minutes, and the reaction mixture was heated at 60°C for 75 min. After cooling the residue dissolved in methanol (300 ml) with water (150 ml) the solution was heated to 50°C and the pH adjusted to about 10.5 by 10 N sodium hydroxide. After 4-5 hours the pH didn't decrease, and the hydrolysis was complete. The reaction mixture was cooled to 20°C and neutralized by adding hydrochloric acid. After stirring overnight 5-Acetamido- 2,4,6-triiodo-N,N'-bis(2,3-dihydroxypropyl)-isophthalamide was filtered and washed with water. Yield: 94 g (80%). Melting point 275°C, dec.
    2-Methoxyethanol (300 ml) and sodium hydroxide (20 g) was added to the reactor at 50°C, and 5-acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6- triiodoisophtalamide (304 g) was added after two hours of stirring. All solids were allowed to dissolve overnight before cooling to 30°C and adjustment to pH 12 with diluted hydrochloric acid. Epichlorohydrin (11 g) was added to the solution after further cooling to 15°C, and the reaction was allowed to proceed for 51 hours. As a result 1,3-bis(acetamido)-N,N'-bis[3,5-bis(2,3- dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane was obtained.
  • brand name Visipaque (GE Healthcare).
  • Therapeutic Function Diagnostic aid
  • General Description Iodixanol is a viscous, isosmolar,nonionic, water-soluble dimer with 49% iodine content.It is formulated as an isotonic solution for intravascular injectionand indicated for excretory urography, angiography,and CT procedures.
Iodixanol Preparation Products And Raw materials
Raw materials
Preparation Products
Iodixanol Suppliers
Global(273)Suppliers
  • Supplier：
    Henan Tianfu Chemical Co.,Ltd.
  • Tel：+86-0371-55170693<br/>+86-19937530512
  • Email：info@tianfuchem.com
  • Country：China
  • ProdList：21628
  • Advantage：55
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：sales@coreychem.com
  • Country：China
  • ProdList：29859
  • Advantage：58
Iodixanol Spectrum
92339-11-2, IodixanolRelated Search:
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  • C35H44I6N6O15
  • 16253-78-3
  • 922339-11-2
  • IODIXANOL 碘克沙醇 |CAS 92339-11-2
  • 碘克沙醇,10 MM DMSO 溶液
  • 5,5'-((2-羟基丙基-1,3-二基)双(乙酰基氮烷二基))双(N1,N3-双(2,3-二羟基丙基)-2,4,6-三碘间苯二甲酰胺)
  • 99.0%碘克沙醇
  • 碘克沙醇92339-11-2
  • 碘杂醇
  • 碘克沙醇 EP标准品
  • 碘克沙醇 USP标准品
  • IODIXANOL,CERTIFIED 标准品
  • 5,5'-[(2-羟基-1,3-丙二基)双(乙酰氨基)]双[N,N'-双(2,3-二羟基丙基)-2,4,6-三碘-1,3-苯二羧酰胺]
  • 5,5'-((2-羟基-1,3-丙烷)双(乙酰亚氨))双(N,N'-二(2,3-二羟基丙基)-2,4,6-三碘-1,3-苯二甲酰胺
  • 1,3-双(乙酰胺基)-N,N'-双[3,5-双(2,3-二羟丙基氨羰基)-2,4,6-三碘苯基]-2-羟基丙烷[中文名] 碘克沙醇
  • 1,3-双(乙酰胺基)-N,N'-双[3,5-双(2,3-二羟丙基氨羰基)-2,4,6-三碘苯基]-2-羟基丙烷
  • 典海醇
  • 碘克沙醇
  • 碘G沙醇
  • 92339-11-2
  • OptiPrep<sup>?</sup> Density Gradient Medium
  • Iothalamate
  • Iodixanol, 10 mM in DMSO
  • 5-(Acetyl-(3-(acetyl-(3,5-bis(2,3-dihydroxypropylcarbamoyl)-2,4,6-triiodophenyl)amino)-2- hydroxypropyl)amino)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide
  • C14330000 Iodixanol
  • 5,5'-((2-Hydroxypropane-1,3-diyl)bis(acetylazanediyl))bis(N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide) , Iodixanol
  • Ioxaxol
  • Ioxanol
  • Visipaque
  • OptiPrep
  • Iodixanol (1343517)
  • IodixanolQ: What is Iodixanol Q: What is the CAS Number of Iodixanol Q: What is the storage condition of Iodixanol Q: What are the applications of Iodixanol

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