Originator
Tiomesterone,Yick-Vik Chemicals
and Pharmaceticals
(H.K.) Ltd.
Uses
Tiomesterone is an anabolic steroid and a derivative of testosterone (T155000), the principal hormone of the testes, produced by the interstitial cells.
Definition
ChEBI: Tiomesterone is a 3-hydroxy steroid. It has a role as an androgen.
Manufacturing Process
4 g 17α-methyl-1,4,6-androstatriene-17β-ol-3-one are boiled in 12 ml
thioacetic acid under reflux for 1.5 hours. This reaction mixture is thereafter
concentrated in vacuum to dryness and the 1α,7α -diacetylthio-17β-hydroxy-
17-methylandrost-4-en-3-one is crystallized from the residue after treatment
with methanol; melting point 202-204°C; [α]D = -74.6° (dioxane); λmax 237.5
nm.
Therapeutic Function
Anabolic
