Description
2-Ethylaniline is a yellow liquid that turnsbrown on standing in air. Molecular weight = 121.20;Boiling point = 215℃; 210℃ at 760 mmHg; Freezing/Melting point = 44℃; Vapor pressure = 0.11 mmHg at20℃; Flash point = 85℃ (oc). Hazard Identification (basedon NFPA-704 M Rating System): Health 3, Flammability 2,Reactivity 0. Insoluble in water.
Chemical Properties
clear yellow to red-brownish liquid
Chemical Properties
2-Ethylaniline is a yellow liquid that turns
brown on standing in air
Uses
Intermediate for pharmaceuticals, dyestuffs,
pesticides, and other products.
Uses
2-Ethylaniline is a reagent in the synthesis of bromoanthraquinones with different substituents producing novel dyes. Also used in the optimization of phoephoinositide 3-kinase inhibitor which is used in the synthesis.
Synthesis Reference(s)
The Journal of Organic Chemistry, 45, p. 4926, 1980
DOI: 10.1021/jo01312a021
General Description
A brown liquid. Insoluble in water and less dense than water. Hence floats on water. Flash point 185°F. May irritate skin, eyes and mucous membranes. Toxic by ingestion, inhalation or skin absorption.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
2-Ethylaniline neutralizes acids in exothermic reactions to form salts plus water. May react with acids to release toxic fumes of aniline and oxides of nitrogen. Reacts violently with oxidizing materials. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Health Hazard
TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Fire Hazard
Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.
Flammability and Explosibility
Not classified
Safety Profile
: A poison. Moderately
toxic by ingestion. Flammable when
exposed to heat or flame; can react with
oxidizing materials. To fight fire, use foam,
CO2, dry chemical. When heated to
decomposition it emits highly toxic fumes of
aniline and NOx. See also NETHYLANILINE.
Potential Exposure
This material is used in making drugs,
dyes, and pesticides.
First aid
Eye Contact: Immediately remove any contactlenses and flush with large amounts of water for at least15 min, occasionally lifting upper and lower lids. Seek medicalattention if any symptoms are present. Skin Contact: Quicklyremove contaminated clothing. Immediately wash area withlarge amounts of soap; promptly seek medical attention.Breathing: Remove the person from exposure. Begin rescuebreathing (using universal precautions, including resuscitationmask) if breathing has stopped and CPR if heart action hasstopped. Transfer promptly to a medical facility.
storage
Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with thischemical you should be trained on its proper handling andstorage. 2-Ethylaniline must be stored to avoid contact withstrong acids (such as hydrochloric, sulfuric, and nitric),strong oxidizers, acid anhydrides (such as maleic anhydride), and chloroformates since violent reactions occur.Store in tightly closed containers in a cool, well-ventilatedarea. Sources of ignition, such as smoking and open flames,are prohibited where 2-ethylaniline is used, handled, orstored in a manner that could create a potential fire orexplosion hazard
Shipping
UN2273 2-Ethylaniline, Hazard Class: 6.1;
Labels: 6.1-Poisonous materials.
Incompatibilities
Combustible; vapor may form explosive
mixture with air above 80℃. Decomposes on contact with
light or air. Incompatible with oxidizers (chlorates, nitrates,
peroxides, permanganates, perchlorates, chlorine, bromine,
fluorine, etc.); contact may cause fires or explosions. Keep
away from alkaline materials, strong bases, strong acids,
oxoacids, epoxides, anhydrides, and chloroformates.
Contact with metals may evolve flammable hydrogen gas.
