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2-Fluoroaniline

CAS No.348-54-9
Chemical Name:2-Fluoroaniline
CBNumber:CB6853530
Molecular Formula:C6H6FN
Formula Weight:111.12
MOL File:348-54-9.mol

2-Fluoroaniline Property

Melting point -29 °C
Boiling point 182-183 °C(lit.)
Density 1.151 g/mL at 25 °C(lit.)
vapor pressure 1 hPa (20 °C)
refractive index n20/D 1.544(lit.)
Flash point 140 °F
storage temp. Store below +30°C.
solubility 17g/l
pka 3.2(at 25℃)
form Liquid
color Clear colorless
Specific Gravity 1.151
Water Solubility 17 g/L (20°C)
BRN 1524219
CAS DataBase Reference 348-54-9(CAS DataBase Reference)
FDA UNII SE32ZK6617
NIST Chemistry Reference Benzenamine, 2-fluoro-(348-54-9)
EPA Substance Registry System o-Fluoroaniline (348-54-9)
UNSPSC Code 12352116
NACRES NA.25

Safety

Hazard Codes :Xn,T,Xi
Risk Statements :22-37/38-41-36/38-33-23/24/25
Safety Statements :26-39-37/39-45-36/37-28
RIDADR :UN 2941 6.1/PG 3
WGK Germany :2
RTECS :BY1390000
Autoignition Temperature :600 °C
Hazard Note :Toxic/Irritant
TSCA :T
HazardClass :6.1
PackingGroup :III
HS Code :29214210

NFPA 704:

	2
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H226-H302-H314-H373-H410
Precautionary statements P210-P273-P280-P303+P361+P353-P305+P351+P338-P314

2-Fluoroaniline Price More Price(11)

Brand: Sigma-Aldrich(India)
Product number: F3401
Product name : 2-Fluoroaniline
Purity: ≥99%
Packaging: 25G
Price: ₹4827.95
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: F3401
Product name : 2-Fluoroaniline
Purity: ≥99%
Packaging: 100G
Price: ₹8237.83
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: F3401
Product name : 2-Fluoroaniline
Purity: ≥99%
Packaging: 500G
Price: ₹31814.68
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: 8.20565
Product name : 2-Fluoroaniline
Purity: for synthesis
Packaging: 100ML
Price: ₹13550
Updated: 2022/06/14
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Brand: TCI Chemicals (India)
Product number: F0032
Product name : 2-Fluoroaniline
Purity: min. 99.0 %
Packaging: 25G
Price: ₹2000
Updated: 2022/05/26
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2-Fluoroaniline Chemical Properties,Usage,Production

Chemical Properties 2-Fluoroaniline is a clear colorless to brown liquid, toxic, insoluble in water, soluble in ethanol and ether, its vapor and air can form an explosive mixture, which can cause combustion and explosion in case of fire and high heat. Reacts with oxidants. Decomposed by high heat to release toxic gases.
Uses 2-Fluoroaniline (cas# 348-54-9) is a useful reagent for the synthesis of insecticides.
Application 2-Fluoroaniline can be used to synthesize thermosensitive dye FH-102, which is a black thermosensitive dye with wide application and excellent performance. The dye can be used in the production of terminal output printing paper of electronic computer, EEG recording paper, telephone fax paper and transparent thermal film for oil field.
Definition ChEBI: 2-fluoroaniline is a derivative of aniline in which the hydrogen at position 2 has been substituted by fluorine. It is used as a pharmaceutical intermediate It is a primary arylamine and a fluoroaniline.
Synthesis Reference(s) Tetrahedron Letters, 25, p. 3415, 1984 DOI: 10.1016/S0040-4039(01)91034-2
General Description Clear liquid with a mild sweet odor. Sinks in and mixes slowly with water.
Air & Water Reactions Water soluble.
Reactivity Profile 2-Fluoroaniline is a base. Neutralizes acids to form salts plus water in an exothermic reaction. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Health Hazard Inhalation or ingestion causes bluish tint to fingernails, lips and ears indicative of cyanosis; headache, drowsiness, and nausea, followed by unconsciousness. Liquid can be absorbed through skin and cause similar symptoms. Contact with eyes causes irritation.
Fire Hazard Special Hazards of Combustion Products: Irritating and toxic hydrogen fluoride and oxides of nitrogen may form in fires.
Biological Activity The metabolism and excretion of the xenobiotic compound 2-fluoroaniline is important due to human exposure in manufacturing. It is found to be very efficiently metabolized, primarily by 4-hydroxylation with subsequent sulfate or glucuronide formation. N-Acetylation is also observed. at least 80% of the dose is excreted in the urine within 24 hr. 2-Fluoroaniline exerts its nephrotoxic effect through 4-hyroxylation and subsequent p-benzoquinonimine formation.
Metabolic pathway 2-Fluoro and 3-fluoroanilines are preferentially hydroxylated at the para-position, and 4-fluoroaniline is both p- and o-hydroxylated to a significant extent by rat liver microsomes and is not accompanied with an NIH shift to give 4-hydroxyl-3-fluoroaniline.