Benzyldiphenylphosphine

Chemical Properties

White to off-white powder

Uses

Employed as a catalyst for Suzuki cross-coupling and antiarthritic agent (inhibitor of cathepsin B). It is also used as catalyst in pharmaceutical research.

Uses

suzuki reaction

Preparation

An acetato-bridged binuclear cyclopalladated complex of benzyldiphenylphosphine, [{Pd(C6H4CH2PPh2)(O2CMe)}], could been obtained by the reaction between the phosphine and palladium(II) acetate[1].

reaction suitability

reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
reagent type: ligand
reaction type: Cross Couplings

References

[1] Katsuma Hiraki, Toshinobu Uchiyama, Yoshio Fuchita. “Cyclopalladation of benzyldiphenylphosphine by palladium(II) acetate.” Inorganica Chimica Acta 69 (1983): Pages 187-190.