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PD 123319 ditrifluoroacetate

PD 123319 ditrifluoroacetate Structure
PD 123319 ditrifluoroacetate
  • CAS No.130663-39-7
  • Chemical Name:PD 123319 ditrifluoroacetate
  • CBNumber:CB3669147
  • Molecular Formula:C31H32N4O3
  • Formula Weight:508.61
  • MOL File:130663-39-7.mol
PD 123319 ditrifluoroacetate Property
  • Boiling point 775.8±60.0 °C(Predicted)
  • Density 1.22±0.1 g/cm3(Predicted)
  • storage temp. 2-8°C
  • solubility H2O: 12 mg/mL
  • form powder
  • pka 2.80±0.20(Predicted)
  • Water Solubility Soluble to 100 mM in water
Safety
  • Hazard Codes  :Xi
  • Risk Statements  :36/37/38
  • Safety Statements  :26
  • WGK Germany  :3
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P305+P351+P338

PD 123319 ditrifluoroacetate Chemical Properties,Usage,Production

  • Uses PD 123319 is a selective non-peptide angiotensin AT2 receptor antagonist.
  • Definition ChEBI: An imidazopyridine consisting of 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine having 4-(dimethylamino)-3-methylbenzyl, diphenylacetyl and carboxy and groups at positions 1, 5 and 6 respectively
  • Biological Activity Potent, selective, non-peptide angiotensin AT 2 receptor antagonist. IC 50 values are 34 and 210 nM in rat adrenal tissue and brain respectively.
  • IC 50 AT2 Receptor
  • References [1] blankley c j, hodges j c, klutchko s r, et al. synthesis and structure-activity relationships of a novel series of non-peptide angiotensin ii receptor binding inhibitors specific for the at2 subtype. journal of medicinal chemistry, 1991, 34(11): 3248-3260.
    [2] boulay g, servant g, luong t t, et al. modulation of angiotensin ii binding affinity by allosteric interaction of polyvinyl sulfate with an intracellular domain of the dup-753-sensitive angiotensin ii receptor of bovine adrenal glomerulosa. molecular pharmacology, 1992, 41(4): 809-815.
    [3] siragy h. angiotensin ii receptor blockers: review of the binding characteristics. the american journal of cardiology, 1999, 84(10): 3-8.
PD 123319 ditrifluoroacetate Preparation Products And Raw materials
Raw materials
Preparation Products
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PD 123319 ditrifluoroacetate Spectrum
130663-39-7, PD 123319 ditrifluoroacetateRelated Search:
  • Angiotensin
  • Inhibitors
  • 抑制剂
  • 合成有机化合物配体
  • 小分子抑制剂，天然产物
  • 内分泌与激素
  • C31H32N4O32CF3CO2H
  • (6S)-1-[[4-(二甲氨基)-3-甲基苯基]甲基]-5-(2,2-二苯乙酰基)-4,5,6,7-四氢-1H-咪唑并[4,5-C]吡啶-6-羧酸
  • 化合物PD123319,10 MM DMSO 溶液
  • 化合物PD123319
  • 130663-39-7
  • PD 123319, 10 mM in DMSO
  • (S)-(+)-PD 123319|||PD123319
  • PD-123319 free base
  • PD 123319 ditrifluor
  • PD 123319 ditrifluoroacetate USP/EP/BP
  • PD-123319 TFA salt
  • CS-953
  • PD123319, >=98%
  • 1-[[4-(dimethylamino)-3-methylphenyl]methyl]-5-(2,2-diphenylacetyl)-6,7-dihydro-4H-imidazo[4,5-c]pyridine-6-carboxylic acid
  • PD123319 TFA
  • (6S)-1-[[4-(Dimethylamino)-3-methylphenyl]methyl]-5-(2,2-diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid
  • (S)-(+)-PD 123319
  • ditrifluoroacetate
  • 1H-IMidazo[4,5-c]pyridine-6-carboxylic acid, 1-[[4-(diMethylaMino)-3-Methylphenyl]Methyl]-5-(2,2-diphenylacetyl)-4,5,6,7-tetrahydro-, (6S)-
  • 1H-Imidazo(4,5-C)pyridine-6-carboxylic acid, 1-((4-(dimethylamino)-3-methylphenyl)methyl)-5-(diphenylacetyl)-4,5,6,7-tetrahydro-, (S)-
  • (6S)-1-[4-Dimethylamino-3-methylbenzyl]-5-diphenylacetyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6α-carboxylic acid
  • (6S)-1-[4-(Dimethylamino)-3-methylbenzyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid
  • (6S)-1-[[4-(Dimethylamino)-3-methylphenyl]methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6α-carboxylic acid
  • s-(+)-1-[(4-(dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine-6-carboxylic acid ditrifluoroacetate
  • pd 123,319 di(trifluoroacetate) salt
  • 1-((4-(Dimethylamino)-3-methylphenyl)methyl)-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4.5-c]pyridine-6-carboxyli
  • PD 123,319 DITRIFLUOROACETATE POTENT AND SELECTIVE
  • S(+)-1-[[4-(DIMETHYLAMINO)-3-METHYLPHENYL]METHYL]-5-(DIPHENYLACETYL)-4,5,6,7-TETRAHYDRO-1H-IMIDAZOL[4,5-C]PYRIDINE-6-CARBOXYLIC ACID DITRIFLUOROACETATE
  • PD 123,319 DITRIFLUOROACETATE
  • PD 123,319
  • (3S)-9-[(4-DIMETHYLAMINO-3-METHYL-PHENYL)METHYL]-4-(2,2-DIPHENYLACETYL)-4,7,9-TRIAZABICYCLO[4.3.0]NONA-7,10-DIENE-3-CARBOXYLIC ACID
  • 1-[[4-(DIMETHYLAMINO)-3-METHYLPHENYL]METHYL]-5-(DIPHENYLACETYL)-4,5,6,7-TETRAHYDRO-1H-IMIDAZO[4,5-C]PYRIDINE-6-CARBOXYLIC ACID DITRIFLUOROACETATE

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