130663-39-7

PD 123319 is a selective non-peptide angiotensin AT2 receptor antagonist.

ChEBI: An imidazopyridine consisting of 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine having 4-(dimethylamino)-3-methylbenzyl, diphenylacetyl and carboxy and groups at positions 1, 5 and 6 respectively

Potent, selective, non-peptide angiotensin AT 2 receptor antagonist. IC 50 values are 34 and 210 nM in rat adrenal tissue and brain respectively.

This potent non-peptide receptor antagonist (FW = 508.61 g/mol; CAS 130663-39-7), also named 1-[[4- (dimethylamino) -3-methylphenyl]methyl]- 5- (2,2-diphenylacetyl) -4,5,6,7-tetrahydro- (6S) -1H-imidazo[4,5-c]pyridine- 6-carboxylate, selectively targets AT2 angiotensin II receptor (IC50 = 34 nM). This class of 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6- carboxylic acid derivatives displace 125I-labeled angiotensin II from a specific subset of angiotensin II (Ang II) binding sites (that are different from those mediating vascular contraction or aldosterone release) that are likely to have novel properties. PD-123319 and another nonpeptide antagonist (DuP-753) discriminate between two subclasses of All receptors in many different tissues. PD 123319 does not influence baseline cerebral blood flow, with minor drop in blood pressure.

Store at -20°C

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