Physcion (20 or 40 mg/kg, p.o., once daily for 7 days) exerts neuroprotective effects by inhibiting the TLR4/NF-κB signaling pathway in an ischemia-reperfusion-induced SD rat model[3].
Physcion (4 or 9 mg/kg, p.o., once daily for 6 days) effectively alleviates infection symptoms caused by Chlamydia psittaci 6 BCE in SPF chickens[4].
| Animal Model: | Ischemia-reperfusion (I/R)-induced focal cerebral ischemia model in SD rats[3] |
| Dosage: | 20 or 40 mg/kg |
| Administration: | Oral gavage (p.o.), once daily for 7 days |
| Result: | Significantly reduced the brain water content and the NSS (Neurological Severity Score) in I/R rats, compared to I/R group.
Obviously decreased areas of infarction compared to I/R group. |
| Animal Model: | SPF chickens (21 days old) infected intra-laryngeally with Chlamydia psittaci 6 BCE[4] |
| Dosage: | 4 or 9 mg/kg |
| Administration: | Oral gavage (p.o.), once daily for 6 days |
| Result: | Dose-dependently alleviated respiratory distress, air sac and lung lesions, and bacterial load in the spleen in infected chickens. |
