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Emodin-3-methyl ether

CAS No.521-61-9
Chemical Name:Emodin-3-methyl ether
CBNumber:CB3487525
Molecular Formula:C16H12O5
Formula Weight:284.26
MOL File:521-61-9.mol

Emodin-3-methyl ether Property

Melting point 196-206°C
Boiling point 560.5±50.0 °C(Predicted)
Density 1.448±0.06 g/cm3(Predicted)
storage temp. -20°C Freezer, Under Inert Atmosphere
solubility Chloroform (Slightly, Heated), Ethyl Acetate (Slightly, Heated), Methanol (Slightly)
form Solid
pka 6.23±0.20(Predicted)
color Yellow to Dark Yellow to Dark Orange
BRN 6770499
Stability Hygroscopic
InChIKey FFWOKTFYGVYKIR-UHFFFAOYSA-N
LogP 5.078 (est)
CAS DataBase Reference 521-61-9(CAS DataBase Reference)
FDA UNII H6PT94IV61
UNSPSC Code 85151701
NACRES NA.25

Safety

Hazard Codes :Xi
Risk Statements :36/37/38
Safety Statements :26
WGK Germany :3
RTECS :CB6720000
F :10
HS Code :29146990

NFPA 704:

	0
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H302
Precautionary statements P264-P270-P301+P312-P501

Emodin-3-methyl ether Price More Price(2)

Brand: Sigma-Aldrich(India)
Product number: 93893
Product name : Physcion
Purity: analytical standard
Packaging: 10MG
Price: ₹30104.33
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 17797
Product name : Physcion
Purity: ≥98.0% (TLC)
Packaging: 100MG
Price: ₹40377.25
Updated: 2022/06/14
Buy: Buy

Emodin-3-methyl ether Chemical Properties,Usage,Production

Chemical Properties Yellow Solid
Uses A natural anthraquinone derivative, on the infection process of Blumeria graminis on wheat. Physcion is one of the important active ingredients of ethanol extract from the roots of Chinese rhubarb (Rheum officinale) for controlling powdery mildew.
Uses antibacterial, cathartic
Definition ChEBI: A dihydroxyanthraquinone that is 9,10-anthraquinone bearing hydroxy substituents at positions 1 and 8, a methoxy group at position 3, and a methyl group at position 6.
Biological Activity Anthraquinone-derivative found in medicinal herbs.

in vivo

Physcion (20 or 40 mg/kg, p.o., once daily for 7 days) exerts neuroprotective effects by inhibiting the TLR4/NF-κB signaling pathway in an ischemia-reperfusion-induced SD rat model^[3]. Physcion (4 or 9 mg/kg, p.o., once daily for 6 days) effectively alleviates infection symptoms caused by Chlamydia psittaci 6 BCE in SPF chickens^[4].

Animal Model:	Ischemia-reperfusion (I/R)-induced focal cerebral ischemia model in SD rats^[3]
Dosage:	20 or 40 mg/kg
Administration:	Oral gavage (p.o.), once daily for 7 days
Result:	Significantly reduced the brain water content and the NSS (Neurological Severity Score) in I/R rats, compared to I/R group. Obviously decreased areas of infarction compared to I/R group.

Animal Model:	SPF chickens (21 days old) infected intra-laryngeally with Chlamydia psittaci 6 BCE^[4]
Dosage:	4 or 9 mg/kg
Administration:	Oral gavage (p.o.), once daily for 6 days
Result:	Dose-dependently alleviated respiratory distress, air sac and lung lesions, and bacterial load in the spleen in infected chickens.