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METHOXY-(-)-VERAPAMIL HYDROCHLORIDE

METHOXY-(-)-VERAPAMIL HYDROCHLORIDE Structure
METHOXY-(-)-VERAPAMIL HYDROCHLORIDE
  • CAS No.36622-40-9
  • Chemical Name:METHOXY-(-)-VERAPAMIL HYDROCHLORIDE
  • CBNumber:CB3393460
  • Molecular Formula:C28H40N2O5
  • Formula Weight:484.63
  • MOL File:36622-40-9.mol
METHOXY-(-)-VERAPAMIL HYDROCHLORIDE Property
  • Boiling point 605.9±55.0 °C(Predicted)
  • Density 1.068±0.06 g/cm3(Predicted)
  • solubility H2O: soluble
  • pka 8.96±0.50(Predicted)
  • FDA UNII 5X7S7C93QM
Safety
  • WGK Germany  :3
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

METHOXY-(-)-VERAPAMIL HYDROCHLORIDE Chemical Properties,Usage,Production

  • Uses (-)-Gallopamil exerts a selective modulation of the fast voltage-dependent inactivation. (-)-Gallopamil inhibits efficiently Cav1.2 constructs formed by β-subunits (promoting fast voltage-dependent inactivation). (-)-Gallopamil also accelerates the voltage-dependent phase of ICa decay (as well as the voltage-dependent decay of Ba2+ currents). (-)-Gallopamil is promising for research of antiarrhythmics[1][2].
  • References [1] Sokolov S, et al. On the role of Ca(2+)- and voltage-dependent inactivation in Ca(v)1.2 sensitivity for the phenylalkylamine (-)gallopamil. Circ Res. 2001 Oct 12;89(8):700-8. DOI:10.1161/hh2001.098983
    [2] Sokolov S, et al. Inactivation determinant in the I-II loop of the Ca2+ channel alpha1-subunit and beta-subunit interaction affect sensitivity for the phenylalkylamine (-)gallopamil. J Physiol. 1999 Sep 1;519 Pt 2(Pt 2):315-22. DOI:10.1111/j.1469-7793.1999.0315m.x
METHOXY-(-)-VERAPAMIL HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
METHOXY-(-)-VERAPAMIL HYDROCHLORIDE Suppliers
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METHOXY-(-)-VERAPAMIL HYDROCHLORIDE Spectrum
36622-40-9, METHOXY-(-)-VERAPAMIL HYDROCHLORIDERelated Search:
  • Voltage-gated Ion Channels
  • Verapamil
  • Calcium Channel Modulators
  • 抑制剂
  • Voltage-gated Ion Channels
  • Ion Channels
  • Cell Signaling and Neuroscience
  • Calcium Channel Modulators
  • Cell Biology
  • BioChemical
  • C28H40N2O5HCl
  • 化合物 GALLOPAMIL, (-)-
  • 化合物 T24083
  • 36622-40-9
  • Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4,5-trimethoxy-α-(1-methylethyl)-, (αS)-
  • Gallopamil, ( ) ,Gallopamil, ()
  • (-)-Methoxyverapamil
  • (-)-Gallopamil
  • (-)-D 600
  • METHOXY-(-)-VERAPAMIL HYDROCHLORIDE
  • (-)-METHOXYVERAPAMIL HYDROCHLORIDE
  • (-)-VERAPAMIL, METHOXY-, HYDROCHLORIDE

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