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PINOCEMBRIN

PINOCEMBRIN Structure
PINOCEMBRIN
  • CAS No.480-39-7
  • Chemical Name:PINOCEMBRIN
  • CBNumber:CB3378883
  • Molecular Formula:C15H12O4
  • Formula Weight:256.25
  • MOL File:480-39-7.mol
PINOCEMBRIN Property
  • Melting point 202 °C
  • Boiling point 511.1±50.0 °C(Predicted)
  • Density 1.386±0.06 g/cm3(Predicted)
  • storage temp. under inert gas (nitrogen or Argon) at 2-8°C
  • solubility Soluble in ethanol and methan
  • form powder
  • pka 7.50±0.40(Predicted)
  • color White
  • LogP 3.225 (est)
  • FDA UNII 8T7C8CH791
  • EPA Substance Registry System 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-phenyl-, (2S)- (480-39-7)
  • UNSPSC Code 41116107
  • NACRES NA.24
Safety
  • Safety Statements  :24/25
  • HS Code  :29329990
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P305+P351+P338

PINOCEMBRIN Chemical Properties,Usage,Production

  • Description Pinocembrin is a flavonoid that has been found in Eucalyptus, and has diverse biological activities. It induces apoptosis in, and inhibits the migration of, SKOV3 ovarian cancer cells when used at a concentration of 200 μM. Pinocembrin (5 mg/kg) reduces lesion volume, as well as brain microglial activation and production of IL-1β, IL-6, and TNF-α in a mouse model of collagenase-induced intracerebral hemorrhage (ICH). It prevents increases in plasma and kidney malondialdehyde (MDA) levels, glomeruli lobulation, mesangial expansion, and tubule vacuolization and occlusion, and it decreases hepatic cholesterol, triglyceride, and LDL levels in a rat model of diabetic nephropathy. Pinocembrin (20 and 50 mg/kg) reduces pulmonary edema, as well as neutrophil, lymphocyte, and macrophage infiltration in a mouse model of LPS-induced lung injury.
  • Chemical Properties Solid
  • Uses Pinocembrin is a flavanoid with antioxidant activity found in damiana, honey, and propolis. Recent studies show that Pinocembrin maybe be a therapeutic option in reducing cerebral ischemia/reperfusion injury as a result of its anti-oxidative and anti-apoptotic effects. Pinocembrin displayed neuroprotective effects in glutamate injury model partly by inhibiting p53 expression causing a lower Bax-Bcl-2 ratio and by inhibiting the release of cytochrome c.
  • Definition ChEBI: Pinocembrin is a dihydroxyflavanone in which the two hydroxy groups are located at positions 5 and 7. A natural product found in Piper sarmentosum and Cryptocarya chartacea. It has a role as an antioxidant, an antineoplastic agent, a vasodilator agent, a neuroprotective agent and a metabolite. It is a dihydroxyflavanone and a (2S)-flavan-4-one.
PINOCEMBRIN Preparation Products And Raw materials
Raw materials
Preparation Products
PINOCEMBRIN Suppliers
Global(235)Suppliers
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：sales@coreychem.com
  • Country：China
  • ProdList：29859
  • Advantage：58
  • Supplier：
    BOC Sciences
  • Tel：+1-631-485-4226
  • Email：inquiry@bocsci.com
  • Country：United States
  • ProdList：19552
  • Advantage：58
PINOCEMBRIN Spectrum
480-39-7, PINOCEMBRINRelated Search:
  • Flavanones
  • standardized herbal extract
  • reference standards from Chinese medicinal herbs (TCM).
  • phytochemical
  • pharmaceutical intermediate
  • chemical reagent
  • Inhibitors
  • 抑制剂
  • 医用原料
  • 中药标准品，对照品
  • 试剂
  • 药靶配体
  • 医药原料
  • 标准品，对照品
  • 标准品 -中药标准品
  • 黄酮
  • 原料
  • 标准品-中药标准品
  • 分析试剂标准品
  • 黄酮类
  • 小分子抑制剂
  • 小分子抑制剂，天然产物
  • 植物提取物
  • 标准品
  • 中药对照品
  • 植提标准品
  • 对照品
  • 乔松素,10 MM DMSO 溶液
  • 乔松素, 分析对照品,ANALYTICAL REFERENCE,500MG
  • 乔松素/二氢黄酮类
  • 乔松素,生松素,松鼠素
  • 乔松素 >99%纯度 入库:150G
  • 乔松素, 分析对照品
  • 标准品对照品】PINOCEMBRIN
  • (S)-5,7-二羟基-2-苯基苯并二氢吡喃-4-酮
  • 乔松素对照品
  • 乔松素(生松素)
  • PINOCEMBRIN 乔松素 标准品
  • 松属素, 来源于五针松
  • 松属素,球松素
  • 乔松素, 来源于五针松
  • 乔松素(标准品)
  • 乔松素/松属素
  • 乔松素(松属素,球松素)
  • PINOCEMBRIN 乔松素
  • 松属素
  • 480-39-7
  • Pinocembrin / Herb cardamom extract
  • Pinocembrin, 10 mM in DMSO
  • Pinocembrin-RM
  • Inhibitor,Bacterial,Autophagy,Reactive Oxygen Species,(+)-Pinocoembrin,inhibit,Pinocembrin
  • (+)-Pinocembrin
  • pinocemberin
  • (S)-5,7-Dihydroxy-2-Phenylchroman-4-One
  • 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-phenyl-, (2S)-
  • (2S)-5,7-Dihydroxy-2-phenylchroman-4-one
  • Pinocembrin, 98%, from Pinus cerebra
  • 5,7-dihydroxy-2-phenyl-2,3-dihydro-4H-chromen-4-one

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