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Ropivacaine mesylate

Ropivacaine mesylate Structure
Ropivacaine mesylate
  • CAS No.854056-07-8
  • Chemical Name:Ropivacaine mesylate
  • CBNumber:CB3353781
  • Molecular Formula:C18H30N2O4S
  • Formula Weight:370.51
  • MOL File:854056-07-8.mol
Ropivacaine mesylate Property
  • storage temp. Store at -20°C
  • form Solid
  • color White to off-white
  • Water Solubility Water: 250 mg/mL (674.75 mM)
  • FDA UNII MJO2D2C5RI
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Ropivacaine mesylate Chemical Properties,Usage,Production

  • Uses Ropivacaine mesylate is a long-acting amide local anaesthetic agent for a spinal block and effectively blocks neuropathic pain. Ropivacaine blocks impulse conduction via reversible inhibition of?sodium ion influx?in nerve fibressup>[1][2]. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel)?TREK-1?with an IC50?of 402.7 μM in COS-7 cell's membrane[3].
  • in vivo

    Epidural administration of Ropivacaine mesylate effectively blocks neuropathic pain (both mechanical allodynia and heat hyperalgesia) without induction of analgesic tolerance and significantly delays the development of neuropathic pain produced by peripheral nerve injury[1].
    Ropivacaine mesylate inhibits pressure-induced increases in filtration coefficient (Kf) without affecting pulmonary artery pressure (Ppa), pulmonary capillary pressures (Ppc), and zonal characteristics (ZC)[2].
    Ropivacaine mesylate prevents pressure-induced lung edema and associated hyperpermeability as evidence by maintaining PaO2, lung wet-to-dry ratio and plasma volume in levels similar to sham rats[2].
    Ropivacaine mesylate inhibits pressure-induced NO production as evidenced by decreased lung nitro-tyrosine content when compared to hypertensive lungs[2].

    Animal Model:Adult Sprague-Dawley rats (300-400g)[2]
    Dosage:1 μM
    Administration:Infusion (added to the perfusate reservoir)
    Result:Attenuated pressure-dependent increases in filtration coefficient (Kf).
  • References [1] Li TF, et al. Epidural sustained release ropivacaine prolongs anti-allodynia and anti-hyperalgesia in developing and established neuropathic pain. PLoS One. 2015 Jan 24;10(1):e0117321. DOI:10.1371/journal.pone.0117321
    [2] Milan Patel, et al. Ropivacaine Inhibits Pressure-Induced Lung Endothelial Hyperpermeability in Models of Acute Hypertension. Life Sci. 2019 Apr 1;222:22-28. DOI:10.1016/j.lfs.2019.02.053
    [3] Dene Simpson, et al. Ropivacaine: a review of its use in regional anaesthesia and acute pain management. Drugs. 2005;65(18):2675-717. DOI:10.2165/00003495-200565180-00013
    [4] Hye Won Shin, et al. The inhibitory effects of bupivacaine, levobupivacaine, and ropivacaine on K2P (two-pore domain potassium) channel TREK-1. J Anesth. 2014 Feb;28(1):81-6. DOI:10.1007/s00540-013-1661-1
Ropivacaine mesylate Preparation Products And Raw materials
Raw materials
Preparation Products
Ropivacaine mesylate Suppliers
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Ropivacaine mesylate Spectrum
854056-07-8, Ropivacaine mesylateRelated Search:
  • 854056-07-8
  • 化学试剂
  • 抑制剂
  • 药靶配体
  • 柏锦生物
  • 科研原料
  • 医药原料
  • 医药原料药
  • 药物杂质及中间体
  • 中药对照品
  • 标准品
  • 医药原料药-科研原料
  • 医药 局麻药
  • 原料药
  • 麻醉剂类Narcotic
  • C17H26N2OCH3O3S
  • C17H26N2OCH4O3S
  • 甲磺酸罗哌卡因(罗哌卡因杂质42)
  • 化合物 ROPIVACAINE MESYLATE
  • (S)-N-(2,6-二甲基苯基)-1-丙基-2-哌啶酰胺甲磺酸盐
  • S-(-)-N-(2,6-二甲基苯基)-1-丙基-2-哌啶甲酰胺甲磺酸盐
  • 甲磺酸罗哌卡因中间体
  • 罗哌卡因甲磺酸盐
  • 甲磺酸罗哌卡因854056-07-8
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  • 甲磺酸罗哌卡因
  • N-(2,6-二甲基苯基)-1-丙基哌啶-2-甲酰胺甲磺酸盐
  • 854056-07-8
  • S-(-)-N-(2,6-Dimethylphenyl)-1-propyl-2-piperidinecarboxamidemethanesulfonate
  • TIANFUCHEM--854056-07-8--Ropivacaine mesylate in stock
  • (S)-N-(2,6-Dimethylphenyl)-1-propylpiperidine-2-carboxamidemethanesulfonate
  • Ropivacaine mesylate USP/EP/BP
  • Ropivacaine Mesylate Injection
  • Ropivacaine mesylate (2S)-N-(2,6-Dimethylphenyl)-1-propyl-2-piperidinecarboxamide monomethanesulfonate
  • Ropivacaine Mesylate API
  • (2S)-N-(2,6-Dimethylphenyl)-1-propyl-2-piperidinecarboxamide monomethanesulfonate
  • ROPIVACAINE MESYLATE

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