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Sodium Pyrithione

CAS No.3811-73-2
Chemical Name:Sodium Pyrithione
CBNumber:CB3352724
Molecular Formula:C5H6NNaOS
Formula Weight:151.16
MOL File:3811-73-2.mol

Sodium Pyrithione Property

Melting point -25 °C
Boiling point 109 °C
Density 1.22
vapor pressure 0-0Pa at 25℃
refractive index 1.4825
storage temp. Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility H₂O: 0.1 M at 20 °C, clear, faintly yellow
form Solution
color very deep brown
biological source synthetic
Water Solubility 54.7 g/100 mL
Sensitive Hygroscopic
λmax 334nm(H2O)(lit.)
Merck 14,7994
BRN 4026050
InChIKey WNGMMIYXPIAYOB-UHFFFAOYSA-M
LogP -2.38 at 20℃ and pH7
Surface tension 65.013-72.6mN/m at 1-1.02g/L and 20-20.1℃
CAS DataBase Reference 3811-73-2(CAS DataBase Reference)
EWG's Food Scores 1-3
FDA UNII 6L3991491R
EPA Substance Registry System Sodium (2-pyridylthio)-N-oxide (3811-73-2)
UNSPSC Code 51102829
NACRES NA.85

Safety

Hazard Codes :Xn,Xi
Risk Statements :22-36/37/38-36/38
Safety Statements :26-36-24/25-37/39
RIDADR :UN 3334
WGK Germany :3
RTECS :UT9000000
F :3-13
TSCA :Yes
HS Code :29333990

NFPA 704:

	1
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H315-H319-H335
Precautionary statements P261-P264-P271-P280-P302+P352-P305+P351+P338

Sodium Pyrithione Price More Price(13)

Brand: Sigma-Aldrich(India)
Product number: H3261
Product name : 2-Mercaptopyridine N-oxide sodium salt
Purity: ≥96%
Packaging: 1G
Price: ₹6646.55
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: H3261
Product name : 2-Mercaptopyridine N-oxide sodium salt
Purity: ≥96%
Packaging: 10G
Price: ₹16107.6
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: H3261
Product name : 2-Mercaptopyridine N-oxide sodium salt
Purity: ≥96%
Packaging: 100G
Price: ₹93030.05
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 63846
Product name : 2-Mercaptopyridine N-oxide sodium salt solution
Purity: ~40% in H2O, very deep brown
Packaging: 500ML
Price: ₹25666.08
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 329061
Product name : 2-Mercaptopyridine N-oxide sodium salt
Purity: 95%
Packaging: 5G
Price: ₹5574.88
Updated: 2022/06/14
Buy: Buy

Sodium Pyrithione Chemical Properties,Usage,Production

Description Sodium pyrithione is mainly used for anti-mildew and antibacterial products in the fields of daily chemicals (shampoo and hair care products), architectural coatings, adhesives, sealants, pesticides, textiles, leather products, metal working fluids, etc. It can also be formulated for disinfection agents, detergents and medical broad-spectrum antifungal dermatological products. At the same time, it is also an effective fungicide and an excellent common disinfectant for fruit trees, peanuts, wheat, vegetables and other crops. Its derivative product, zinc pyrithione, is also a commonly used fungicide for daily chemicals.
Chemical Properties sodium pyrithione belongs to pyridine derivatives fungicide, appearance is yellow full light dumpling transparent liquid, melting point 250 ℃, slightly characteristic odor. Soluble in water and ethanol and other organic solvents, solubility (by mass fraction): water 53%, ethanol 19%, polyethylene glycol (PECG400) 12%. Best use pH range 7 to 10, mass fraction of 2% aqueous solution pH 8.0. Unstable to light, oxidizing agents and strong reducing agents. Non-ionic surfactants will deactivate it somewhat, and it can chelate with heavy metals.
Uses sodium pyrithione is a preservative that is not commonly used because of some level of toxicity. It is prohibited in Canada, and it is on the eu Annex II list of substances that must not form part of a cosmetic product composition.
Uses Sodium omadine is a bactericide for use in cooling fluids and short-term in-can preservation of vinyl acetate latex, paints, and synthetic-fiber lubricants; preservative for cosmetic rinse-off products.
Application 2-Mercaptopyridine N-oxide sodium salt is one of the active components in paint, sealants, shampoo, adhesive and aerosol due to its anti-microbial activity. In biochemistry studies, it is utilized to transport zinc into cells. Further, it is used to form bidentate oxothiolane chelates with transition metals. It acts as a stabilizer and viscosity building provider in weak basic or neutral medium.
Definition Apparently exists in equilibrium with the -SH form. Forms chelates with iron, manganese, zinc, etc.
brand name Sodium Omadine (Olin).
General Description 2-Mercaptopyridine N-oxide acts as labelling agent during indium-111 labelling of human platelets. It acts as bioactive ligand and forms palladium and platinum complexes, which were tested as potential antitrypanosomal agents.
Biochem/physiol Actions 2-Mercaptopyridine N-oxide is a zinc ionophore that transports zinc into cells.
Safety Profile Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion, subcutaneous and parenteral routes. Used in preservation of cosmetics. When heated to decomposition it emits very toxic fumes of Na2O, NOx, and SOx. See also MERCAPTANS.
Purification Methods When recrystallised from water, it assayed as 98.7% based on AgNO3 titration [Krivis et al. Anal Chem 35 966 1963; see also Krivis et al. Anal Chem 48 1001 1976, and Barton & Crich J Chem Soc, Perkin Trans 1 1603, 1613 1986]. [Beilstein 21/7 V 151.]
Mode of action Pyrithione Sodium is the sodium salt form of pyrithione, a fungistatic and antimicrobial derivative of aspergillic acid. Although the exact mechanism of action remains to be fully elucidated, pyrithione sodium appears to interfere with membrane transport ultimately leading to a loss of metabolic control.