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DIGITONIN

CAS No.11024-24-1
Chemical Name:DIGITONIN
CBNumber:CB3331307
Molecular Formula:C56H92O29
Formula Weight:1229.31
MOL File:11024-24-1.mol

DIGITONIN Property

Melting point 230-240 °C (dec.)(lit.)
Boiling point 788.4°C (rough estimate)
alpha D20 -54° (0.45 g in 15.8 ml methanol)
Density 1.1421 (rough estimate)
refractive index -52 ° (C=1, EtOH)
storage temp. Sealed in dry,Room Temperature
solubility H₂O: 10 mg/mL at 95 °C hot, clear, colorless
form White powder
pka 12.68±0.70(Predicted)
color white
optical activity [α]20/D 54°, c = 2.8 in methanol(lit.)
biological source plant seeds (Digitalis purpurea)
Water Solubility H2O: ~5% (w/v) (solubilized by heating to 95 °C - 98 °C and then cooling to room temp.)
Merck 14,3161
BRN 78654
Stability Hygroscopic
InChIKey FAAZZWIYYDUONB-JYIJKGCVSA-N
EWG's Food Scores 1
FDA UNII KOO5CM684H
EPA Substance Registry System Digitonin (11024-24-1)
UNSPSC Code 12161900
NACRES NA.25

Safety

Hazard Codes :T
Risk Statements :23/24/25
Safety Statements :22-28-36/37-45
RIDADR :UN 3462 6.1/PG 3
WGK Germany :3
RTECS :IH2050050
F :3-10
HazardClass :6.1(a)
PackingGroup :II
HS Code :29389090

NFPA 704:

	0
4		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H301-H373
Precautionary statements P301+P310+P330-P314

DIGITONIN Price More Price(10)

Brand: Sigma-Aldrich(India)
Product number: D5628
Product name : Digitonin
Purity: ~50% (TLC)
Packaging: 1G
Price: ₹46536.68
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: D5628
Product name : Digitonin
Purity: ~50% (TLC)
Packaging: 5G
Price: ₹110166.03
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: D141
Product name : Digitonin
Purity: Used as non-ionic detergent
Packaging: 100MG
Price: ₹9417.75
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: D141
Product name : Digitonin
Purity: Used as non-ionic detergent
Packaging: 500MG
Price: ₹30418.25
Updated: 2022/06/14
Buy: Buy

Brand: TCI Chemicals (India)
Product number: D0540
Product name : Digitonin
Purity:
Packaging: 100MG
Price: ₹5100
Updated: 2022/05/26
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DIGITONIN Chemical Properties,Usage,Production

Chemical Properties white crystalline powder
Uses Natural surfactant useful for receptor solubilization and cell permeabilization, e.g., blood platelets, hepatocytes, yeast or tumor cells
Uses enhances membrane permeability
Uses Digitonin has been used in a study to assess a procedure for isolating mitochondria from ascites tumor cells. It has also been used in a study to investigate its effect on the cytotoxicity of plant secondary metabolites in cancer cells. This mild nonionic detergent can be used to solubilize receptors and permeabilize cellular and nuclear membranes.
Uses Clinical reagent (cholesterol determination).
General Description Crystals or white powder.
Air & Water Reactions Forms soapy aqueous suspension .
Reactivity Profile DIGITONIN is incompatible with strong oxidizing agents and strong acids. (NTP, 1992
Fire Hazard Flash point data for DIGITONIN are not available; however, DIGITONIN is probably combustible.
Biological Activity Digitonin plays a key role in permeabilizing cell membranes. It is capable of lysing eukaryotic cells but not bacterial membranes. It is also used to solubilize membrane components. It helps to create pores by interacting specifically with cholesterol in the membrane. It is preferred in biotechnology due to its mild detergency. This membrane-active compound act with doxorubicin against multi-drug resistant cancer cells.
Safety Profile Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Mutation data reported. See also DIGITALIS. When heated to decomposition it emits acrid smoke and irritating fumes.
Purification Methods This digitoxin hexa-glycoside can be recrystallised from aqueous 85% EtOH or MeOH/diethyl ether. It is purified by preparative paper chromatography and developed with the upper phase of a mixture of nBuOH/H2O/AcOH (4:5:1), and the spot (RF 0.36) is eluted with 25% CCl3CO2H in CHCl3. It has also been purified by countercurrent distribution. It forms an ethanolate, and complexes with cholesterol and other sterols. [Ruhenstroth-Bauer & Breitenfeld Hoppe Seyler's Z Physiol Chem 302 111 1955, Grisvold J Am Pharm Assoc 23 664 1934, Beilstein 19 IV 1243.]