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Aminooxy-PEG1-propargyl

Aminooxy-PEG1-propargyl Structure
Aminooxy-PEG1-propargyl
  • CAS No.1895922-69-6
  • Chemical Name:Aminooxy-PEG1-propargyl
  • CBNumber:CB33162830
  • Molecular Formula:C5H9NO2
  • Formula Weight:115.13
  • MOL File:1895922-69-6.mol
Aminooxy-PEG1-propargyl Property
  • Boiling point 212.1±20.0 °C(Predicted)
  • Density 1.035±0.06 g/cm3(Predicted)
  • solubility Soluble in Water, DMSO, DMF
  • form Liquid
  • pka 4.09±0.70(Predicted)
  • color Colorless to light yellow
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Aminooxy-PEG1-propargyl Chemical Properties,Usage,Production

  • Description Aminooxy-PEG1-propargyl is a click chemistry PEG linker containing a propargyl group and an aminooxy group. The aminooxy group is reactive with an aldehyde or ketone group to form a stable oxime linkage. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended.
  • Uses Aminooxy-PEG1-propargyl is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Aminooxy-PEG1-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
  • IC 50 PEGs
  • References [1] Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228. DOI:10.1016/j.bmc.2019.115228
Aminooxy-PEG1-propargyl Preparation Products And Raw materials
Raw materials
Preparation Products
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Aminooxy-PEG1-propargyl Spectrum
1895922-69-6, Aminooxy-PEG1-propargylRelated Search:
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  • Aminooxy-PEG1-propargyl HCl salt
  • Aminooxy-PEG1-propargyl

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