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Bromo-PEG1-CH2CO2tBu

Bromo-PEG1-CH2CO2tBu Structure
Bromo-PEG1-CH2CO2tBu
  • CAS No.157759-50-7
  • Chemical Name:Bromo-PEG1-CH2CO2tBu
  • CBNumber:CB33062437
  • Molecular Formula:C8H15BrO3
  • Formula Weight:239.11
  • MOL File:157759-50-7.mol
Bromo-PEG1-CH2CO2tBu Property
  • Boiling point 268.1±15.0 °C(Predicted)
  • Density 1.301±0.06 g/cm3(Predicted)
  • solubility Soluble in DCM
  • form Liquid
  • color Colorless to light yellow
Safety
  • HS Code  :2920907090
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H318-H315-H335-H302
  • Precautionary statements P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501-P280-P305+P351+P338-P310

Bromo-PEG1-CH2CO2tBu Chemical Properties,Usage,Production

  • Description Bromo-PEG1-CH2CO2tBu is a PEG linker containing a bromide group and a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
  • Uses Bromo-PEG1-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
  • IC 50 PEGs; Alkyl/ether
  • References [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Bromo-PEG1-CH2CO2tBu Preparation Products And Raw materials
Raw materials
Preparation Products
Bromo-PEG1-CH2CO2tBu Suppliers
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Bromo-PEG1-CH2CO2tBu Spectrum
157759-50-7, Bromo-PEG1-CH2CO2tBuRelated Search:
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