ChemicalBook > CAS DataBase List > 3,7,9-TRIHYDROXY-1-METHYL-6H-DIBENZO[B,D]PYRAN-6-ONE

3,7,9-TRIHYDROXY-1-METHYL-6H-DIBENZO[B,D]PYRAN-6-ONE

3,7,9-TRIHYDROXY-1-METHYL-6H-DIBENZO[B,D]PYRAN-6-ONE Structure
3,7,9-TRIHYDROXY-1-METHYL-6H-DIBENZO[B,D]PYRAN-6-ONE
  • CAS No.641-38-3
  • Chemical Name:3,7,9-TRIHYDROXY-1-METHYL-6H-DIBENZO[B,D]PYRAN-6-ONE
  • CBNumber:CB3297090
  • Molecular Formula:C14H10O5
  • Formula Weight:258.23
  • MOL File:641-38-3.mol
3,7,9-TRIHYDROXY-1-METHYL-6H-DIBENZO[B,D]PYRAN-6-ONE Property
  • Melting point 350°C (rough estimate)
  • Boiling point 321.48°C (rough estimate)
  • Density 1.2211 (rough estimate)
  • refractive index 1.4560 (estimate)
  • storage temp. 2-8°C
  • solubility ≤0.5mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
  • pka 7.16±0.20(Predicted)
  • form Solid
  • color Off-white to brown
  • BRN 244839
  • Stability Hygroscopic
  • FDA UNII KN9L4260JW
  • UNSPSC Code 85151701
  • NACRES NA.77
Safety
  • Hazard Codes  :T+
  • Risk Statements  :26/27/28
  • Safety Statements  :28-36/37/39-45
  • RIDADR  :UN 3462 6.1/PG 1
  • WGK Germany  :3
  • RTECS  :HP8757000
  • HazardClass  :6.1(b)
  • PackingGroup  :III
  • HS Code  :29322090
  • Toxicity :LDLo intraperitoneal in mouse: 100mg/kg
  • NFPA 704:
    0
    4 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H300+H310+H330
  • Precautionary statements P262-P280-P301+P310+P330-P302+P352+P310-P304+P340+P310
3,7,9-TRIHYDROXY-1-METHYL-6H-DIBENZO[B,D]PYRAN-6-ONE Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: A1312
  • Product name : Alternariol from Alternaria sp.
  • Purity: ~96%
  • Packaging: 5MG
  • Price: ₹79877.68
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 35758
  • Product name : Alternariol
  • Purity: analytical standard
  • Packaging: 100μG
  • Price: ₹79423.03
  • Updated: 2022/06/14
  • Buy: Buy

3,7,9-TRIHYDROXY-1-METHYL-6H-DIBENZO[B,D]PYRAN-6-ONE Chemical Properties,Usage,Production

  • Description Alternariol is a mycotoxin, a toxic secondary fungal metabolite, produced by Alternaria molds. It is cytotoxic, fetotoxic, teratogenic, mutagenic, and genotoxic. It induces cytochrome P450 1A1 expression and apoptosis in mouse hepatoma cells (20-40 μM). Alternariol, whose synthesis is inhibited by light, naturally occurs on fruits, vegetables, and cereals, such as apples, tomatoes, and wheat.
  • Uses An alternaria mycotoxin and genotoxin, found in common edible crops. It inhibits the activity of various DNA-topoisomerases, increasing he rate of DNA strand breaks.
  • Uses Alternariol from Alternaria sp. may be used as a calibration standard in reverse phase high-performance liquid chromatography (HPLC) and UV-spectrum analysis. It may also be used to spike wholemeal wheat flour for wet baking studies
  • Definition ChEBI: A benzochromenone that is 6H-benzo[c]chromen-6-one which is substituted by a methyl group at position 1 and by hydroxy groups at positions 3, 7, and 9. It is the most important mycotoxin produced by the black mould Alt rnaria species, which are the most common mycoflora infecting small grain cereals worldwide.
  • Synthesis Reference(s) The Journal of Organic Chemistry, 70, p. 3275, 2005 DOI: 10.1021/jo050075r
  • General Description Alternariol belongs to the dibenzo-pyrones chemical group. It is a mycotoxin present in indoor air, soil and plants.
  • Biochem/physiol Actions Alternaria mycotoxins are generally associated with undried food grains post-harvest. The disease caused by Alternaria mycotoxin results in a discolored halo in fruits and spotting in leaves. Alternariol (AOH) is cytotoxic and fetotoxic to microbes and mammalian cells. AOH displays inhibitory effect on cell proliferation and has estrogenic functionality.
  • References [1] tiemann u, tomek w, schneider f, et al. the mycotoxins alternariol and alternariol methyl ether negatively affect progesterone synthesis in porcine granulosa cells in vitro[j]. toxicology letters, 2009, 186(2): 139-145.
    [2] sderhll k, svensson e, unestam t. light inhibits the production of alternariol and alternariol monomethyl ether in alternaria alternata[j]. applied and environmental microbiology, 1978, 36(5): 655-657.
    [3] schreck i, deigendesch u, burkhardt b, et al. the alternaria mycotoxins alternariol and alternariol methyl ether induce cytochrome p450 1a1 and apoptosis in murine hepatoma cells dependent on the aryl hydrocarbon receptor[j]. archives of toxicology, 2012, 86(4): 625-632.
3,7,9-TRIHYDROXY-1-METHYL-6H-DIBENZO[B,D]PYRAN-6-ONE Preparation Products And Raw materials
Raw materials
Preparation Products
3,7,9-TRIHYDROXY-1-METHYL-6H-DIBENZO[B,D]PYRAN-6-ONE Suppliers
Global(104)Suppliers
  • Supplier：
    BOC Sciences
  • Tel：+1-631-485-4226
  • Email：inquiry@bocsci.com
  • Country：United States
  • ProdList：19552
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32159
  • Advantage：58
  • Supplier：
    Career Henan Chemica Co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：laboratory@coreychem.com
  • Country：China
  • ProdList：30231
  • Advantage：58
  • Supplier：
    Alfa Chemistry
  • Tel：
  • Email：Info@alfa-chemistry.com
  • Country：United States
  • ProdList：24072
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：
  • Email：support@targetmol.com
  • Country：United States
  • ProdList：38630
  • Advantage：58
  • Supplier：
    Aladdin Scientific
  • Tel：
  • Email：tp@aladdinsci.com
  • Country：United States
  • ProdList：57505
  • Advantage：58
3,7,9-TRIHYDROXY-1-METHYL-6H-DIBENZO[B,D]PYRAN-6-ONE Spectrum
641-38-3, 3,7,9-TRIHYDROXY-1-METHYL-6H-DIBENZO[B,D]PYRAN-6-ONERelated Search:
  • Inhibitor
  • Mutagenesis Research Chemicals
  • Inhibitors
  • 中药标准品，对照品
  • 抑制剂
  • 药靶配体
  • 标准品
  • 医药原料
  • 其它酚类
  • 合成
  • 替萘洛尔
  • 乙腈中交链孢酚
  • 乙腈中交链孢酚-D2
  • 乙腈中交链孢酚/(AOH)
  • 乙腈中U-[13C14]-交链孢酚
  • 交链孢酚/(AOH)
  • 甲醇中交链孢酚
  • 交替醇
  • 13C14-交链孢酚
  • 格链孢醇
  • 3,7,9-三羟基-1-甲基-6H-苯[C]苯并吡喃-6-酮
  • 隔交链孢
  • 格链孢菌醇
  • 交链孢
  • 交链孢酚
  • 641-38-3
  • Alternariol from <i>Alternaria</i> sp.
  • Alternariol in Acetonitrile
  • Alternariol 100 μg/ml Acetonitrile
  • U-{13C14}-Alternariol in acetonitrile
  • Alternariol in dried down
  • 13C14]-Alternariol- 25 μg/Ml in CAN
  • 13C14-Alternariol
  • Alternariol 50ug/ml in ACN
  • 6H-Dibenzo[b,d]pyran-6-one,3,7,9-trihydroxy-1-methyl-
  • Alternariol/AOH
  • 3,7,9-Trihydroxy-1-methyl-benzo[c]chromen-6-one
  • Alternariol 3,7,9-Trihydroxy-1-Methyl-6H-Dibenzo[b,d]Pyran-6-One
  • ALTERNARIOL
  • 3,7,9-trihydroxy-1-Methyl-6H-benzo[c]chroMen-6-one
  • NSC 638263
  • Alternariol 99%
  • Alternariol from Alternaria sp.,3,7,9-Trihydroxy-1-methyl-6H-dibenzo[b,d]pyran-6-one
  • 1-Methyl-3,7,9-trihydroxy-6H-dibenzo[b,d]pyran-6-one
  • DIBENZO(B,D)PYRAN-6-ONE,1-METHYL-3,7,9-TRIHYDROXY-
  • alternariol from alternaria sp.
  • d)pyran-6-one,1-methyl-3,7,9-trihydroxy-6h-dibenzo(
  • aoh
  • 3,7,9-TRIHYDROXY-1-METHYL-6H-DIBENZO[B,D]PYRAN-6-ONE

Home

My