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HYOCHOLIC ACID

HYOCHOLIC ACID Structure
HYOCHOLIC ACID
  • CAS No.547-75-1
  • Chemical Name:HYOCHOLIC ACID
  • CBNumber:CB3141135
  • Molecular Formula:C24H40O5
  • Formula Weight:408.57
  • MOL File:547-75-1.mol
HYOCHOLIC ACID Property
  • Melting point 162 °C
  • Boiling point 565.7±40.0 °C(Predicted)
  • Density 1.184±0.06 g/cm3(Predicted)
  • storage temp. Store at -20°C
  • solubility Ethanol (Slightly), Methanol (Slightly, Heated)
  • form Solid
  • pka 4.76±0.10(Predicted)
  • color Light Brown to Brown
  • optical activity +5.525
  • FDA UNII 2H5H0Q47FL
  • UNSPSC Code 12352211
  • NACRES NA.25
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

HYOCHOLIC ACID Chemical Properties,Usage,Production

  • Uses 3α,6α,7α-Trihydroxy-5β-cholanic Acid is one of the bile acids categorizes under muricholic acid, a group of bile acids found in human urine due to its additional hydroxyl groups. The synthesis of 3α,6α,7α-Trihydroxy-5β-cholanic Acid was shown to be promoted due to overexpression of cholesterol 7α-hydroxylase enzyme.
  • Definition ChEBI: A trihydroxy-5beta-cholanic acid in which the three hydroxy substituents are located at the 3alpha-, 6alpha- and 7alpha-positions.
  • Biological Activity Hyocholic acid levels are elevated in plasma and urine samples of patients with cholestatic liver disease and in hepatic cirrhosis.
  • in vivo

    Hyocholic Acid (20 mg/kg, p.o.) suppresses BA depletion-induced blood glucose increase in pigs[3].
    Hyocholic Acid (100 mg/kg/day, p.o.) improves serum fasting GLP-1 secretion and glucose homeostasis in diabetic mouse models[3].

    Animal Model:BA depletion pigs[3]
    Dosage:20 mg/kg
    Administration:Oral administration (p.o.)
    Result:Attenuated the increased blood glucose levels corresponding with GLP-1 decrease.
    Animal Model:db/db model, and the high-fat diet and streptozotocin (HFD+STZ) induced diabetic model[3]
    Dosage:100 mg/kg/day
    Administration:Oral administration (p.o.)
    Result:Improved oral glucose tolerances shown by lower glucose levels.
    Increased circulating active GLP-1 levels and fasting insulin levels.
HYOCHOLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
HYOCHOLIC ACID Suppliers
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HYOCHOLIC ACID Spectrum
547-75-1, HYOCHOLIC ACIDRelated Search:
  • 化工原料
  • 抑制剂
  • 杂质-熊去氧胆酸系列杂质
  • 高端化学
  • 临床检测标准物质
  • 助剂
  • 食品添加剂
  • 原料
  • 杂质对照品
  • HYOCHOLIC ACID 猪胆酸 |CAS 547-75-1
  • 猪胆酸,10 MM DMSO 溶液
  • Γ-鼠胆酸/精确称量
  • (R)-4-((3R,5R,6R,7S,8S,9S,10R,13R,14S,17R)-3,6,7-三羟基-10,13-二甲基十六氢-1H-环戊烷并[A]菲-17-基)戊酸
  • 甲醇中猪胆酸标准溶液
  • 别胆酸杂质11 (猪胆酸)
  • Γ-多元醇酸 (2,2,3,4,4-D5, 99%)
  • Γ-鼠胆酸(猪胆酸)
  • 2H5]-Γ-鼠胆酸
  • 伽马-鼠胆酸
  • 3U0003B1;,6U0003B1;,7U0003B1;-TRIHYDROXY-5U0003B2;-CHOLAN-24-OIC ACID,
  • Γ-多元醇酸
  • 甘氨胆酸钠盐863-57-0|医药级98%甘氨胆酸钠盐|厂家供应甘氨胆酸钠盐
  • 3Α,6Α,7Α-三羟基-5Β-胆酸
  • 5Β-胆甾烷-24-酸-3Α,6Α,7Α-三醇
  • 3Α,6Α,7Α-三羟基-5Β-胆甾烷-24-酸
  • 天然提取物猪胆酸
  • 【厂家供应】甘氨胆酸钠盐863-57-0医药级98%
  • 猪胆酸含量:80%,90%,95% 用于生化研究 中文同义词: 猪胆酸
  • 5Β-胆甾烷-24-酸-3Α,6Α,7Α-三醇 英文名称: HYOCHOLIC ACID 英文同义词: LAMBDA-MURICHOLIC ACID
  • 猪胆酸
  • 547-75-1
  • Hyocholic acid, 10 mM in DMSO
  • 5β-Cholan-24-Oic Acid-3α,6α,7α-Triol
  • γ-Muricholic Acid/Hyocholic Acid
  • gamma-Muricholate
  • alpha-Hyocholic acid
  • Allocholic Acid Impurity 11 (Hyocholic Acid)
  • 2H5]-γ-Muricholic Acid
  • GAMMA-MURICHOLIC ACID
  • 3a,6a,7a-Trihydroxy-5b-cholanic acid
  • Hyocholic acid (HCA)
  • GAMMA MURICHOLIC
  • -trihydroxy-5u0003B2
  • -trihydroxy-5B2
  • -cholan-24-oic acid
  • 7u0003B1
  • 6u0003B1
  • 6B1
  • 3u0003B1
  • 5β-Cholanic acid-3α,6α,7α-triol
  • (R)-4-((3R,5R,6R,7S,8S,9S,10R,13R,14S,17R)-3,6,7-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid
  • Cholan-24-oic acid, 3,6,7-trihydroxy-, (3α,5β,6α,7α)-
  • HYOCHOLIC ACIDHYOCHOLIC ACID
  • Porcine cholic acid
  • 3-ALPHA,6-ALPHA,7-ALPHA-
  • 3α,6α,7α-Trihydroxy-5β-cholanic Acid
  • (4R)-4-[(3R,5R,6R,7S,8S,9S,10R,13R,14S,17R)-3,6,7-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]valeric acid
  • 3α,6α,7α-Trihydroxy-5β-cholan-24-oic acid

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