ChemicalBook > CAS DataBase List > deoxynybomycin
deoxynybomycin
- CAS No.27259-98-9
- Chemical Name:deoxynybomycin
- CBNumber:CB31387501
- Molecular Formula:C16H14N2O3
- Formula Weight:282.29
- MOL File:27259-98-9.mol
deoxynybomycin Property
- Boiling point 470.2±45.0 °C(Predicted)
- Density 1.44±0.1 g/cm3(Predicted)
- pka 1.52±0.60(Predicted)
- Symbol(GHS)
- Signal word
- Hazard statements
- Precautionary statements
deoxynybomycin Chemical Properties,Usage,Production
- Description Deoxynybomycin is a selective anti-tumor agent, inducing apoptosis and inhibiting topoisomerase I.
- Uses Deoxynybomycin is an antibiotic, that can be isolated from Streptomyces, and antibacterial activity against Staphylococcus aureus. Deoxynybomycin is the inhibitor for DNA gyrase and Topoisomerase I. Deoxynybomycin induces expression of p21/WAF1, exhibits cytotoxicity and induces apoptosis in cancer cells Saos-2, TMK-1, and THP-1[1][2].
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References
[1] Parkinson EI, et al., Deoxynybomycins inhibit mutant DNA gyrase and rescue mice infected with fluoroquinolone-resistant bacteria. Nat Commun. 2015 Apr 24;6:6947. DOI:10.1038/ncomms7947
[2] Egawa K, et al., Deoxynybomycin is a selective anti-tumor agent inducing apoptosis and inhibiting topoisomerase I. Biol Pharm Bull. 2000 Sep;23(9):1036-40. DOI:10.1248/bpb.23.1036
deoxynybomycin Preparation Products And Raw materials
Raw materials
Preparation Products
Global(3)Suppliers
-
Supplier：
BOC Sciences
- Tel：+1-631-485-4226
- Email：inquiry@bocsci.com
- Country：United States
- ProdList：19552
- Advantage：58
-
Supplier：
TargetMol Chemicals Inc.
- Tel：+1-781-999-5354<br/>+1-00000000000
- Email：marketing@targetmol.com
- Country：United States
- ProdList：32159
- Advantage：58
27259-98-9, deoxynybomycinRelated Search:
- 化合物 T27147
- 27259-98-9
- 2H,4H-Oxazolo[5,4,3-ij]pyrido[3,2-g]quinoline-4,10(11H)-dione, 6,8,11-trimethyl-
- Deoxynybomycine
- 6,8,11-Trimethyl-4H-oxazolo[5,4,3-ij]pyrido[3,2-g]quinoline-4,10(11H)-dione
- deoxynybomycin
