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Deoxynybomycin is a selective anti-tumor agent, inducing apoptosis and inhibiting topoisomerase I.

Deoxynybomycin is an antibiotic, that can be isolated from Streptomyces, and antibacterial activity against Staphylococcus aureus. Deoxynybomycin is the inhibitor for DNA gyrase and Topoisomerase I. Deoxynybomycin induces expression of p21/WAF1, exhibits cytotoxicity and induces apoptosis in cancer cells Saos-2, TMK-1, and THP-1[1][2].

[1] Parkinson EI, et al., Deoxynybomycins inhibit mutant DNA gyrase and rescue mice infected with fluoroquinolone-resistant bacteria. Nat Commun. 2015 Apr 24;6:6947. DOI:10.1038/ncomms7947
[2] Egawa K, et al., Deoxynybomycin is a selective anti-tumor agent inducing apoptosis and inhibiting topoisomerase I. Biol Pharm Bull. 2000 Sep;23(9):1036-40. DOI:10.1248/bpb.23.1036